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bfrA

General Information
Protegen ID 1829
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Rv
Taxonomy ID 83332
Molecule Role Protective antigen
Molecule Role Annotation Mycobacterium frA (or called MMP-II) is one of the immunodominant antigens (Mukai et al., 2014).
Related Vaccines(s) BCG-DHTM
References
Mukai et al., 2014: Mukai T, Tsukamoto Y, Maeda Y, Tamura T, Makino M. Efficient activation of human T cells of both CD4 and CD8 subsets by urease-deficient recombinant Mycobacterium bovis BCG that produced a heat shock protein 70-M. tuberculosis-derived major membrane protein II fusion protein. Clinical and vaccine immunology : CVI. 2014; 21(1); 1-11. [PubMed: 24152387].
Gene Information
Gene Name bfrA
NCBI Gene ID 885767
Genbank Accession AL123456
Locus Tag Rv1876
Gene Starting Position 2125339
Gene Ending Position 2125818
DNA Sequence 
>NC_000962.3:2125339-2125818 Mycobacterium tuberculosis H37Rv, complete genome
CATGCAAGGTGATCCCGATGTTCTGCGCCTGCTCAACGAACAATTGACCAGCGAGCTCACCGCTATCAAC
CAATACTTTCTGCACTCCAAGATGCAGGACAACTGGGGTTTTACCGAGCTGGCGGCCCACACCCGCGCGG
AGTCGTTCGACGAAATGCGGCACGCCGAGGAAATCACCGATCGCATCTTGTTGCTGGATGGTTTGCCGAA
CTACCAGCGCATCGGTTCGTTGCGTATCGGCCAGACGCTCCGCGAGCAATTTGAGGCCGATCTGGCGATC
GAATACGACGTGTTGAATCGTCTCAAGCCAGGAATCGTCATGTGCCGGGAGAAACAGGACACCACCAGCG
CCGTACTGCTGGAGAAAATCGTTGCCGACGAGGAAGAACACATCGACTACTTGGAAACGCAGCTGGAGCT
GATGGACAAGCTAGGAGAGGAGCTTTACTCGGCGCAGTGCGTCTCTCGCCCACCGACCTG
Protein Information
Protein Name bacterioferritin BfrA
NCBI Protein GI 15609013
Protein Accession NP_216392
Protein pI 4.23
Protein Weight 17744.75
Protein Length 159
Protein Note Also known as bfr
Protein Sequence 
>NP_216392.1 bacterioferritin BfrA [Mycobacterium tuberculosis H37Rv]
MQGDPDVLRLLNEQLTSELTAINQYFLHSKMQDNWGFTELAAHTRAESFDEMRHAEEITDRILLLDGLPN
YQRIGSLRIGQTLREQFEADLAIEYDVLNRLKPGIVMCREKQDTTSAVLLEKIVADEEEHIDYLETQLEL
MDKLGEELYSAQCVSRPPT
Vaxign Prediction
Localization(Probability) Cytoplasmic
(Prob.=0.997)
Adhesin Probability 0.098
Trans-membrane Helices 0
Detailed Vaxign Results Vaxign Results
Epitope Information
IEDB Linear Epitope