VIOLIN: Vaccine Investigation and Online Information Network

LASVsSgp2 glycoprotein

General Information

Protegen ID

Sequence Strain (Species/Organism)

Lassa mammarenavirus

VO ID

VO_0010869

Taxonomy ID

11620

Molecule Role

Protective antigen

Molecule Role Annotation

HLA-A*0201 mice immunized with either GPC(42-50) from LASVsSgp2 glycoprotein or GPC(60-68) were protected against challenge with a recombinant vaccinia virus that expressed LASV GPC (Botten et al., 2006).

Related Vaccines(s)

Lassa fever virus recombinant vector vaccine V-LSG encoding the glycoprotein , Lassa fever virus recombinant vector vaccine V-LSG/N encoding the glycoprotein and the nucleoprotein , ML29 L-AttV, rLCMV(IGR/S-S) (Mopiea/Lassa reassortant) , V-LSGPC , VSV[Delta]G/LVGPC

References

Botten et al., 2006: Botten J, Alexander J, Pasquetto V, Sidney J, Barrowman P, Ting J, Peters B, Southwood S, Stewart B, Rodriguez-Carreno MP, Mothe B, Whitton JL, Sette A, Buchmeier MJ. Identification of protective Lassa virus epitopes that are restricted by HLA-A2. Journal of virology. 2006 Sep; 80(17); 8351-61. [PubMed: 16912286].

Gene Information

Gene Name

LASVsSgp2 glycoprotein

NCBI Gene ID

956585

Genbank Accession

AY628203

Locus Tag

LASVsSgp2

Segment No

segment S

Gene Starting Position

1871

Gene Ending Position

3346

DNA Sequence

>NC_004296.1:1871-3346 Lassa virus segment S, complete sequence
CTCATCTCTTCCATTTCACAGGCACACCAGGCTGTTTGTAGAGTCCACAGGAACAAATGCCCATATGATT
CAATCTGTGAGGTTTGGGACACGACTTGCCTACAATATGCCTATGAGTTGGTATTTTGACTAGGTGAAGG
AAGATGCTAATAAGATAGAAACTTGTACTGAACACAAAGAGGTCAACTAGACCCAATGGTGTCTTCCCCT
GCCTCTCCATATACTCCTTCTGTAACATCTCAGTGATCATATTGTCAGCTTGTTGTTCAATATCATCAGA
AAAGTGGGTCTCGTTCAAGTATGAACCATTTGATACAAGCCAACATTTGGGCAGTGATGTTCTCCCAGTA
GTTGTGTGGTTGAGGTACCAATACTTGCTGTAATTACAGTATGGAATTCCCATGATGTCCCGTAGATGGT
TCTTCATTATAAGTTGGTCATTTATCAAAGCATTTACTGCTTTGTTGATCAACTGAATGCTCATTTGTGC
TTCAGCTTTCAACCTTTGAATGGCTTGTTTGTTGAAGTCAAACAGCCTCAGCATGTCACAAAATTCCTCA
TCATGCTTCTCATTACATTTTGCCACAGCTGTGTTCCCGAAGCATTTTAGTTCAGCCTCAATTAGCATCC
ACCTGGTCAGACAATATCCCCCTGGTGTGTCTTTACCTTCAGAATCTGACAGTGTCCATGTGAATGTGCC
TAGCAATCTTCTACTAATATAAATATCTCTAGTCCTTTGTGAGAGGAGCCCGAGATAACCGATGGGAGAT
GGTCTCGAGAATTGGCAGTGATCTTCCCAGGTTGTATTTTGGATTATCAGATATTGATAACTAGTCATAA
TACAGTCCCAGTTGCCACGGCCTGAGTCAAGAGCAATGTAGCTCCCACCCCAAGCCATCCTCATAAAAGT
CTGTAACACACCATTTGCAACAGTACCACAATGGTTGGCTGCATCCCCAGCATAGCTGTGACTCAGGTTG
TACTGCACACTAATCTTTCCCCCATTAAAATCGCAGCTCATTGCCTCATACTGATTGAAGTTGGGGATGG
ACAAGTGGAAAGTTGAGATTATGCTCATAAGAGCGTGGTCATAGAGGTTCTTTTTGTGGGCATCAGACAG
ATTGCAAAATTTGTGATTAATAATGCTCGTGTTGGTCAAGGTCAGTTCTAGTCCTGTCTCATTGCCCACC
ATTATATAATGATGACTGTTGTTCTTTGTGCAGGAGAGAGGCATGGTCATATTGAGTGTCTCCATGTTTA
GTTCCAGAGTCTGAAGCTCATAAACCCCTTTATAAAGACTGGTTGTGCAAGACCTACCACACAACAGGAG
GAAAGTGACCAAACCAACAAGGCCACACGTTGCAAAATTGTACAGACCTTTCAGCACTGCTAGTACAGAC
AGTGCAATGAGAACAATGTTCATCACCTCTTCTATTACATGAGGCACTTCCTGGAAGAATGTCACTATTT
GTCCCA

Protein Information

Protein Name

glycoprotein

NCBI Protein GI

23343511

Protein Accession

NP_694870

Protein pI

7.63

Protein Weight

53529.32

Protein Length

491

Protein Sequence

>NP_694870.1 glycoprotein [Lassa mammarenavirus]
MGQIVTFFQEVPHVIEEVMNIVLIALSVLAVLKGLYNFATCGLVGLVTFLLLCGRSCTTSLYKGVYELQT
LELNMETLNMTMPLSCTKNNSHHYIMVGNETGLELTLTNTSIINHKFCNLSDAHKKNLYDHALMSIISTF
HLSIPNFNQYEAMSCDFNGGKISVQYNLSHSYAGDAANHCGTVANGVLQTFMRMAWGGSYIALDSGRGNW
DCIMTSYQYLIIQNTTWEDHCQFSRPSPIGYLGLLSQRTRDIYISRRLLGTFTWTLSDSEGKDTPGGYCL
TRWMLIEAELKCFGNTAVAKCNEKHDEEFCDMLRLFDFNKQAIQRLKAEAQMSIQLINKAVNALINDQLI
MKNHLRDIMGIPYCNYSKYWYLNHTTTGRTSLPKCWLVSNGSYLNETHFSDDIEQQADNMITEMLQKEYM
ERQGKTPLGLVDLFVFSTSFYLISIFLHLVKIPTHRHIVGKSCPKPHRLNHMGICSCGLYKQPGVPVKWK
R

Epitope Information

IEDB Linear Epitope