VIOLIN: Vaccine Investigation and Online Information Network

FimH from E. coli UTI89

General Information

Protegen ID

263

Sequence Strain (Species/Organism)

Escherichia coli UTI89

VO ID

VO_0010945

Taxonomy ID

364106

Molecule Role

Protective antigen

Molecule Role Annotation

FimH is a protective antigen (Langermann et al., 1997)

Of the vaccine preparations, Fusion, Fusion + CT, and FimH admixed with FliC and CT showed the best protection against UPEC (Asadi et al., 2016).

References

Langermann et al., 1997: Langermann S, Palaszynski S, Barnhart M, Auguste G, Pinkner JS, Burlein J, Barren P, Koenig S, Leath S, Jones CH, Hultgren SJ. Prevention of mucosal Escherichia coli infection by FimH-adhesin-based systemic vaccination. Science (New York, N.Y.). 1997; 276(5312); 607-611. [PubMed: 9110982].

Gene Information

Gene Name

FimH from E. coli UTI89

NCBI Gene ID

3992235

Genbank Accession

CP000243

Locus Tag

UTI89_C5017

Gene Starting Position

4913554

Gene Ending Position

4914456

DNA Sequence

>NC_007946.1:4913554-4914456 Escherichia coli UTI89, complete genome
AATGAAACGAGTTATTACCCTGTTTGCTGTACTGCTGATGGGCTGGTCGGTAAATGCCTGGTCATTCGCC
TGTAAAACCGCCAATGGTACCGCAATCCCTATTGGCGGTGGCAGCGCCAATGTTTATGTAAACCTTGCGC
CTGCCGTGAATGTGGGGCAAAACCTGGTCGTAGATCTTTCGACGCAAATCTTTTGCCATAACGATTACCC
AGAAACCATTACAGACTATGTCACACTGCAACGAGGTGCGGCTTATGGCGGCGTGTTATCTAGTTTTTCC
GGGACCGTAAAATATAATGGCAGTAGCTATCCTTTCCCTACTACCAGCGAAACGCCGCGGGTTGTTTATA
ATTCGAGAACGGATAAGCCGTGGCCGGTGGCGCTTTATTTGACGCCGGTGAGCAGTGCGGGGGGAGTGGC
GATTAAAGCTGGCTCATTAATTGCCGTGCTTATTTTGCGACAGACCAACAACTATAACAGCGATGATTTC
CAGTTTGTGTGGAATATTTACGCCAATAATGATGTGGTGGTGCCCACTGGCGGCTGCGATGTTTCTGCTC
GTGATGTCACCGTTACTCTGCCGGACTACCCTGGTTCAGTGCCGATTCCTCTTACCGTTTATTGTGCGAA
AAGCCAAAACCTGGGGTATTACCTCTCCGGCACAACCGCAGATGCGGGCAACTCGATTTTCACCAATACC
GCGTCGTTTTCACCCGCGCAGGGCGTCGGCGTACAGTTGACGCGCAACGGTACGATTATTCCAGCGAATA
ACACGGTATCGTTAGGAGCAGTAGGGACTTCGGCGGTAAGTCTGGGATTAACGGCAAATTACGCACGTAC
CGGAGGGCAGGTGACTGCAGGGAATGTGCAATCGATTATTGGCGTGACTTTTGTTTATCAATA

Protein Information

Protein Name

type 1 fimbiral adhesin FimH

NCBI Protein GI

91213965

Protein Accession

YP_543951

3D structure: PDB ID

1TR7

Protein pI

7.88

Protein Weight

27858.43

Protein Length

300

Protein Sequence

>YP_543951.1 type 1 fimbiral adhesin FimH [Escherichia coli UTI89]
MKRVITLFAVLLMGWSVNAWSFACKTANGTAIPIGGGSANVYVNLAPAVNVGQNLVVDLSTQIFCHNDYP
ETITDYVTLQRGAAYGGVLSSFSGTVKYNGSSYPFPTTSETPRVVYNSRTDKPWPVALYLTPVSSAGGVA
IKAGSLIAVLILRQTNNYNSDDFQFVWNIYANNDVVVPTGGCDVSARDVTVTLPDYPGSVPIPLTVYCAK
SQNLGYYLSGTTADAGNSIFTNTASFSPAQGVGVQLTRNGTIIPANNTVSLGAVGTSAVSLGLTANYART
GGQVTAGNVQSIIGVTFVYQ

Epitope Information

IEDB Linear Epitope