VIOLIN: Vaccine Investigation and Online Information Network

GNA1946

General Information

Protegen ID

266

Sequence Strain (Species/Organism)

Neisseria meningitidis MC58

VO ID

VO_0010974

Taxonomy ID

122586

Molecule Role

Protective antigen

Molecule Role Annotation

Protective antigen (Pizza et al., 2000)

COG

COG1464P, under P: Inorganic ion transport and metabolism

References

Pizza et al., 2000: Pizza M, Scarlato V, Masignani V, Giuliani MM, AricÃ² B, Comanducci M, Jennings GT, Baldi L, Bartolini E, Capecchi B, Galeotti CL, Luzzi E, Manetti R, Marchetti E, Mora M, Nuti S, Ratti G, Santini L, Savino S, Scarselli M, Storni E, Zuo P, Broeker M, Hundt E, Knapp B, Blair E, Mason T, Tettelin H, Hood DW, Jeffries AC, Saunders NJ, Granoff DM, Venter JC, Moxon ER, Grandi G, Rappuoli R. Identification of vaccine candidates against serogroup B meningococcus by whole-genome sequencing. Science (New York, N.Y.). 2000; 287(5459); 1816-1820. [PubMed: 10710308].

Gene Information

Gene Name

GNA1946

NCBI Gene ID

904205

Genbank Accession

AE002098

Locus Tag

NMB1946

Gene Starting Position

2041081

Gene Ending Position

2041944

DNA Sequence

>NC_003112.2:2041081-2041944 Neisseria meningitidis MC58 chromosome, complete genome
CTTATTTGGCTGCGCCTTCATTCCATGCGGCAGGGGATTTGTAGCCCTCGAAGCGTTTGTGCGCGTAGGC
TTTGAACGCGTCGGAGTTATAGGCCTCGGTTACGTCTTTAAGCCATTGGCTGTCTTTGTCGGCGGTTTTG
ACGGCAGACCAGTTGACATAGGCAAAGCTCGGTTCTTGGAACAGGGCTTCGGTCAGCTTCATGCCGCTGC
TTATGGCGTAGTTGCCGTTGACGACGGCAAAATCCACGTCGGCGCGGCTACGCGGCAGTTGCGCGGCTTC
AAGCTCGACGATTTTGATGTTTTTCAGGTTCTCGGCGATGTCCGCTTTGGATGCGGTCAACGGATTGATG
CCGTCTTTGAGTTTGATCCAACCCAGTTCGTCGAGCATCACCAAGACGCGGGCGAAGTTGGACGGGTCGT
TGGGCGCGGATACGGTGCTGCCGTCTTTGACTTCTTCCAGCGATTTCAGCTTGCCCGGGTACAGTCCCAA
AGGCGCGGTCGGCACTTGGAAGACTTCGGTGATGTCCAGATTGTGTTCTTTTTTGAAGTCGTCAAGATAG
GGTTTGTGTTGGAAGACGTTGATGTCCAACTCGCCCTCAGCCAATGCCAGATTCGGGCGTACATAGTCGG
TAAACTCGACCAGTTTGACGGTGTAGCCTTTTTTCTCCAGCTCGGCTTGGATTTGTTCTTTGACCATATC
GCCGAAGTCGCCGACGGTCGTGCCGAAGACGATTTCTTTTTTCGCCGCGCCGTTGTCGGCGGCGGCAGAA
GCGGATGCGGCGGGCGCGCTGTCTTTTTGACCGCCGCAGGCGGCGAGGATGAGCGCGAGTGCGGCGGCGG
AAAGGGTTTTGAAGAAGGTTTTCA

Protein Information

Protein Name

outer membrane lipoprotein

NCBI Protein GI

15677776

Protein Accession

NP_274940

3D structure: PDB ID

3GXA

Protein pI

4.96

Protein Weight

29236.71

Protein Length

287

Protein Note

identified by similarity to EGAD:30554; match to protein family HMM PF03180

Protein Sequence

>NP_274940.1 outer membrane lipoprotein [Neisseria meningitidis MC58]
MKTFFKTLSAAALALILAACGGQKDSAPAASASAAADNGAAKKEIVFGTTVGDFGDMVKEQIQAELEKKG
YTVKLVEFTDYVRPNLALAEGELDINVFQHKPYLDDFKKEHNLDITEVFQVPTAPLGLYPGKLKSLEEVK
DGSTVSAPNDPSNFARVLVMLDELGWIKLKDGINPLTASKADIAENLKNIKIVELEAAQLPRSRADVDFA
VVNGNYAISSGMKLTEALFQEPSFAYVNWSAVKTADKDSQWLKDVTEAYNSDAFKAYAHKRFEGYKSPAA
WNEGAAK

Epitope Information

IEDB Linear Epitope