GNA33
General Information
Protegen ID
270
Sequence Strain (Species/Organism)
Neisseria meningitidis MC58
VO ID
VO_0010978
Taxonomy ID
122586
Molecule Role
Protective antigen
Molecule Role Annotation
Protective antigen (Pizza et al. , 2000 )
COG
COG2821M, under M: Cell wall/membrane/envelope biogenesis
References
Pizza et al. , 2000: Pizza M, Scarlato V, Masignani V, Giuliani MM, Aricò B, Comanducci M, Jennings GT, Baldi L, Bartolini E, Capecchi B, Galeotti CL, Luzzi E, Manetti R, Marchetti E, Mora M, Nuti S, Ratti G, Santini L, Savino S, Scarselli M, Storni E, Zuo P, Broeker M, Hundt E, Knapp B, Blair E, Mason T, Tettelin H, Hood DW, Jeffries AC, Saunders NJ, Granoff DM, Venter JC, Moxon ER, Grandi G, Rappuoli R. Identification of vaccine candidates against serogroup B meningococcus by whole-genome sequencing. Science (New York, N.Y.) . 2000; 287(5459); 1816-1820. [PubMed: 10710308 ].
Gene Information
Gene Name
GNA33
NCBI Gene ID
902136
Genbank Accession
AE002098
Locus Tag
NMB0033
Gene Starting Position
30910
Gene Ending Position
32235
DNA Sequence
>NC_003112.2:30910-32235 Neisseria meningitidis MC58 chromosome, complete genome
TTTACGGGCGGTATTCGGGCTTCATACCGTTGGGTAGGAGCTGCCAGACATATCCCGTGGTTTTCTGTTT
GCCGGCAAGTTCGCCGGCTTCGTCGCCGTATCCCCAAAAATAATCCACGCGCACCGCGCCTTTAATCGCG
CTGCCGGTATCCTGCGCCATAATCAGGCGGTTGAGGGCTTTGCGGGTAACCGGATGGGCGGTGGCGACAA
ATAAGGGCGCACCCAAGGTAATGTAGTGCCGGTCGACTGCGCCGGCATATTCCCCCATCAGCGGCGTGCC
CAGTGCGCCGACAGGGCCGTCATTGCTGCTTCCGGCAAGCTCGCGGAAAAAGATATAGCTGGGGTTTTGA
CCCAAAACTTCGGCGAGGCGTTGCGGATTTTGCCGCATATAAGACTTAATGCCCTGCATGGAGGTTTGTC
CGAGTTTGAGGTAGCCCTTATCCGCCATATAGCGTCCGATGGAAACGTAGGGATGTTCGTTTTTGTCGGC
ATAGCCGATGCGGATGTATTTGCCGGACGGGGTTTTCAGACGGCCCGAGCCTTGGATGTGCATAAAAAAA
AGTTCGACAGGGTCTTCGGCGTAACCGAGTATCGGGGCTTTGCCGTCAAGCGCGCCGCCGTTGATTTGGT
TGCGCGTGTGGTAGGGGAGGAAGCGGCTTCCTTCAAACCTGCCTTTGATTGCTGTTGTGCGCGCGGTGAT
GGGGAATCGGGAGAGGTCGGCGGTATGTGTGCCGCCGGTATTGTCGATTGTGCCGCTGTTTTTTCCCGTC
TGCCTGATGCGGACAAGGGCTTTTCCGCTCCGCAAACCGGCAGGCAGGGGGACGGAGATAAAATCGTCGG
GAATACCGTAAATCGGGAAGCGGGCTTGTGCCGTCCGCCTGTCGTCGCCCTTCAGCACCGGTTCGTAATA
GCCGGTAACCGTACCGGCAAGGCTTCCGTTGCCTGCAACCTGCCACGGCGTGAAATAGCGTTCAAAAAAC
TGTTTTGCCTGAAAGGAATGGACGGGGGTTTGAAAGGCTTGGGCGCACACATCCTGCCAGCCTTGGCGGT
TTTTCAAATTGGCGCAGCCGAGGCGGAAGGATTGCAGGCTTTTGGCGAAATCCTGCGCCGCCCAGTGGGG
CAGGGACAGGTGCGGTACAACGGTATAGACGGCCCCGCCGCCGCCGACCGTCGTTCCGGCGGGGTCGGGG
ATGCCGACCGGCCGGTCCGGGCCGTTGATGACGGATGTGTCGGGTTGCGGAAAGGTTTGGATGCTCTTGC
TTTGGCAGGCGGCGAGGATGGCGGCGGCGATGCCGTACAGGGCGGCGCGGAATAGGTATTTTTTCA
Protein Information
Protein Name
membrane-bound lytic murein transglycosylase A
NCBI Protein GI
15675973
Protein Accession
NP_273099
Protein pI
10.02
Protein Weight
45724.72
Protein Length
441
Protein Note
identified by similarity to GP:974447; match to protein family HMM PF03562; match to protein family HMM PF06725
Protein Sequence
>NP_273099.1 membrane-bound lytic murein transglycosylase A [Neisseria meningitidis MC58]
MKKYLFRAALYGIAAAILAACQSKSIQTFPQPDTSVINGPDRPVGIPDPAGTTVGGGGAVYTVVPHLSLP
HWAAQDFAKSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSFQAKQFFERYFTPWQVAGNGSLAGTVTGY
YEPVLKGDDRRTAQARFPIYGIPDDFISVPLPAGLRSGKALVRIRQTGKNSGTIDNTGGTHTADLSRFPI
TARTTAIKGRFEGSRFLPYHTRNQINGGALDGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYA
DKNEHPYVSIGRYMADKGYLKLGQTSMQGIKSYMRQNPQRLAEVLGQNPSYIFFRELAGSSNDGPVGALG
TPLMGEYAGAVDRHYITLGAPLFVATAHPVTRKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGELAGK
QKTTGYVWQLLPNGMKPEYRP
Vaxign Prediction
Localization(Probability)
Outer Membrane (Prob.=0.992)
Adhesin Probability
0.759
Trans-membrane Helices
0
Detailed Vaxign Results
Vaxign Results
Epitope Information
IEDB Linear Epitope
-- Assay Type --
T Cell Epitope
B Cell Epitope
IEDB ID
Epitope
MHC restriction
Starting position
Ending position
IEDB ID
Epitope
Starting position
Ending position
91100
AFQTPVHS
104
112
MKKYLFRAALYGIAAAILAACQSKSIQTFPQPDTSVINGPDRPVGIPDPAGTTVGGGGAVYTVVPHLSLPHWAAQDFAKSLQSFRLGCANLKNRQGWQDVCAQAFQTPVHSFQAKQFFERYFTPWQVAGNGSLAGTVTGYYEPVLKGDDRRTAQARFPIYGIPDDFISVPLPAGLRSGKALVRIRQTGKNSGTIDNTGGTHTADLSRFPITARTTAIKGRFEGSRFLPYHTRNQINGGALDGKAPILGYAEDPVELFFMHIQGSGRLKTPSGKYIRIGYADKNEHPYVSIGRYMADKGYLKLGQTSMQGIKSYMRQNPQRLAEVLGQNPSYIFFRELAGSSNDGPVGALGTPLMGEYAGAVDRHYITLGAPLFVATAHPVTRKALNRLIMAQDTGSAIKGAVRVDYFWGYGDEAGELAGKQKTTGYVWQLLPNGMKPEYRP