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NspA from N. meningitidis MC58

General Information
Protegen ID 271
Sequence Strain (Species/Organism) Neisseria meningitidis MC58
VO ID VO_0010979
Taxonomy ID 122586
Molecule Role Protective antigen
Molecule Role Annotation Protective antigen (Martin et al., 1997)
NspA-containing outer membrane vesicles conferred protection against otherwise lethal intraperitoneal challenge of mice with N. meningitidis serogroup B, and sera raised against them mediated opsonophagocytosis of meningococcal strains expressing this antigen (O'dwyer et al., 2004).
COG COG3637M, under M: Cell wall/membrane/envelope biogenesis
Related Vaccines(s) N. meningitidis NspA Protein Vaccine
References
Martin et al., 1997: Martin D, Cadieux N, Hamel J, Brodeur BR. Highly conserved Neisseria meningitidis surface protein confers protection against experimental infection. The Journal of experimental medicine. 1997; 185(7); 1173-1183. [PubMed: 9104804].
O'dwyer et al., 2004: O'dwyer CA, Reddin K, Martin D, Taylor SC, Gorringe AR, Hudson MJ, Brodeur BR, Langford PR, Kroll JS. Expression of heterologous antigens in commensal Neisseria spp.: preservation of conformational epitopes with vaccine potential. Infection and immunity. 2004; 72(11); 6511-6518. [PubMed: 15501782].
Gene Information
Gene Name NspA from N. meningitidis MC58
NCBI Gene ID 902774
Genbank Accession AE002098
Locus Tag NMB0663
Gene Starting Position 690297
Gene Ending Position 690821
DNA Sequence 
>NC_003112.2:690297-690821 Neisseria meningitidis MC58 chromosome, complete genome
ATCAGAATTTGACGCGCACACCGGCGGACAGTTCGCCGGAACGGACGTTTTTGACAGTGTTGACTTTGCC
GATGTAGTTGTAGCGGTAGCCGGCATCCAAATCGACATTCGGGGTAACGGCATAGCTTACGCCCGTCAAT
ACGCCGAGGCCGATGGAGGTTTGGCTGAAGCTGTCGCTGCCGCCCAAGTCGACGGAGGCGCGGTTGAGGC
TCAAGCGCGCGCCGAGATACGGTTTGACGGGCGATTGGGTGTCGAAGTCGTAAATGGCGGACGCGCCGAT
GCTGTAAAGTTTGAAATCGGTGGATGGGGCTTTATAGTTTTTGTAGCGCGTGTAATCGACGGCGAAGCGG
AGGTCGTTGATGCGGTAGCCTGCGGAGATGCGCGGGCTGAAGCCTTTGGCAGAACCTAAAGAGCTTGAGG
CTTTTGCGTGTGCGGCATCGGCTTGGACGTAAAAGCCGGATGCGCCTTCCGCCAGTGCGGCGGCCGGGAG
AGCGAGGGCAATCAGTGTGGCAAGTGCTTTTTTCA
Protein Information
Protein Name outer membrane protein
NCBI Protein GI 15676561
Protein Accession NP_273705
3D structure: PDB ID 1P4T
Protein pI 10.02
Protein Weight 17106.9
Protein Length 174
Protein Note identified by similarity to EGAD:137514; match to protein family HMM PF02462
Protein Sequence 
>NP_273705.1 outer membrane protein [Neisseria meningitidis MC58]
MKKALATLIALALPAAALAEGASGFYVQADAAHAKASSSLGSAKGFSPRISAGYRINDLRFAVDYTRYKN
YKAPSTDFKLYSIGASAIYDFDTQSPVKPYLGARLSLNRASVDLGGSDSFSQTSIGLGVLTGVSYAVTPN
VDLDAGYRYNYIGKVNTVKNVRSGELSAGVRVKF
Vaxign Prediction
Localization(Probability) Outer Membrane
(Prob.=1)
Adhesin Probability 0.664
Trans-membrane Helices 0
Detailed Vaxign Results Vaxign Results
Epitope Information
IEDB Linear Epitope