VIOLIN: Vaccine Investigation and Online Information Network

NspA from N. meningitidis MC58

General Information

Protegen ID

271

Sequence Strain (Species/Organism)

Neisseria meningitidis MC58

VO ID

VO_0010979

Taxonomy ID

122586

Molecule Role

Protective antigen

Molecule Role Annotation

Protective antigen (Martin et al., 1997)
NspA-containing outer membrane vesicles conferred protection against otherwise lethal intraperitoneal challenge of mice with N. meningitidis serogroup B, and sera raised against them mediated opsonophagocytosis of meningococcal strains expressing this antigen (O'dwyer et al., 2004).

COG

COG3637M, under M: Cell wall/membrane/envelope biogenesis

Related Vaccines(s)

N. meningitidis NspA Protein Vaccine

References

Martin et al., 1997: Martin D, Cadieux N, Hamel J, Brodeur BR. Highly conserved Neisseria meningitidis surface protein confers protection against experimental infection. The Journal of experimental medicine. 1997; 185(7); 1173-1183. [PubMed: 9104804].

O'dwyer et al., 2004: O'dwyer CA, Reddin K, Martin D, Taylor SC, Gorringe AR, Hudson MJ, Brodeur BR, Langford PR, Kroll JS. Expression of heterologous antigens in commensal Neisseria spp.: preservation of conformational epitopes with vaccine potential. Infection and immunity. 2004; 72(11); 6511-6518. [PubMed: 15501782].

Gene Information

Gene Name

NspA from N. meningitidis MC58

NCBI Gene ID

902774

Genbank Accession

AE002098

Locus Tag

NMB0663

Gene Starting Position

690297

Gene Ending Position

690821

DNA Sequence

>NC_003112.2:690297-690821 Neisseria meningitidis MC58 chromosome, complete genome
ATCAGAATTTGACGCGCACACCGGCGGACAGTTCGCCGGAACGGACGTTTTTGACAGTGTTGACTTTGCC
GATGTAGTTGTAGCGGTAGCCGGCATCCAAATCGACATTCGGGGTAACGGCATAGCTTACGCCCGTCAAT
ACGCCGAGGCCGATGGAGGTTTGGCTGAAGCTGTCGCTGCCGCCCAAGTCGACGGAGGCGCGGTTGAGGC
TCAAGCGCGCGCCGAGATACGGTTTGACGGGCGATTGGGTGTCGAAGTCGTAAATGGCGGACGCGCCGAT
GCTGTAAAGTTTGAAATCGGTGGATGGGGCTTTATAGTTTTTGTAGCGCGTGTAATCGACGGCGAAGCGG
AGGTCGTTGATGCGGTAGCCTGCGGAGATGCGCGGGCTGAAGCCTTTGGCAGAACCTAAAGAGCTTGAGG
CTTTTGCGTGTGCGGCATCGGCTTGGACGTAAAAGCCGGATGCGCCTTCCGCCAGTGCGGCGGCCGGGAG
AGCGAGGGCAATCAGTGTGGCAAGTGCTTTTTTCA

Protein Information

Protein Name

outer membrane protein

NCBI Protein GI

15676561

Protein Accession

NP_273705

3D structure: PDB ID

1P4T

Protein pI

10.02

Protein Weight

17106.9

Protein Length

174

Protein Note

identified by similarity to EGAD:137514; match to protein family HMM PF02462

Protein Sequence

>NP_273705.1 outer membrane protein [Neisseria meningitidis MC58]
MKKALATLIALALPAAALAEGASGFYVQADAAHAKASSSLGSAKGFSPRISAGYRINDLRFAVDYTRYKN
YKAPSTDFKLYSIGASAIYDFDTQSPVKPYLGARLSLNRASVDLGGSDSFSQTSIGLGVLTGVSYAVTPN
VDLDAGYRYNYIGKVNTVKNVRSGELSAGVRVKF

Epitope Information

IEDB Linear Epitope