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GNA2091

General Information
Protegen ID 274
Sequence Strain (Species/Organism) Neisseria meningitidis MC58
VO ID VO_0010982
Taxonomy ID 122586
Molecule Role Protective antigen
Molecule Role Annotation Protective antigen as shown in some assays (Giuliani et al., 2006)
COG COG2823R, under R: General function prediction only
References
Giuliani et al., 2006: Giuliani MM, Adu-Bobie J, Comanducci M, Aricò B, Savino S, Santini L, Brunelli B, Bambini S, Biolchi A, Capecchi B, Cartocci E, Ciucchi L, Di Marcello F, Ferlicca F, Galli B, Luzzi E, Masignani V, Serruto D, Veggi D, Contorni M, Morandi M, Bartalesi A, Cinotti V, Mannucci D, Titta F, Ovidi E, Welsch JA, Granoff D, Rappuoli R, Pizza M. A universal vaccine for serogroup B meningococcus. Proceedings of the National Academy of Sciences of the United States of America. 2006; 103(29); 10834-10839. [PubMed: 16825336].
Gene Information
Gene Name GNA2091
NCBI Gene ID 903958
Genbank Accession AE002098
Locus Tag NMB2091
Gene Starting Position 2211862
Gene Ending Position 2212470
DNA Sequence 
>NC_003112.2:2211862-2212470 Neisseria meningitidis MC58 chromosome, complete genome
GATGAAACCCAAACCGCACACCGTCCGCACCCTGATTGCCGCCATTTTCAGCCTTGCCCTTAGCGGCTGC
GTCAGCGCAGTAATCGGAAGCGCCGCCGTCGGCGCGAAATCCGCCGTCGACCGCCGAACCACCGGCGCGC
AAACCGACGACAACGTTATGGCGTTGCGTATCGAAACCACCGCCCGTTCCTATCTGCGCCAAAACAACCA
AACCAAAGGCTACACGCCCCAAATCTCCGTCGTCGGCTACAACCGCCACCTGCTGCTGCTCGGACAAGTC
GCCACCGAAGGCGAAAAACAGTTCGTCGGTCAGATTGCACGTTCCGAACAGGCCGCCGAAGGCGTGTACA
ACTATATTACCGTCGCCTCCCTGCCGCGCACTGCCGGCGACATCGCCGGCGACACTTGGAACACATCCAA
AGTCCGCGCCACGCTGTTGGGCATCAGCCCCGCCACACAGGCGCGCGTCAAAATCGTTACCTACGGCAAC
GTAACCTACGTTATGGGCATCCTCACCCCCGAAGAACAGGCGCAGATTACCCAAAAAGTCAGCACCACCG
TCGGCGTACAAAAAGTCATCACCCTCTACCAAAACTACGTCCAACGCTG
Protein Information
Protein Name hemolysin
NCBI Protein GI 15677911
Protein Accession NP_275079
Protein pI 10.22
Protein Weight 19563.68
Protein Length 202
Protein Note identified by similarity to EGAD:28637; match to protein family HMM PF04972
Protein Sequence 
>NP_275079.1 hemolysin [Neisseria meningitidis MC58]
MKPKPHTVRTLIAAIFSLALSGCVSAVIGSAAVGAKSAVDRRTTGAQTDDNVMALRIETTARSYLRQNNQ
TKGYTPQISVVGYNRHLLLLGQVATEGEKQFVGQIARSEQAAEGVYNYITVASLPRTAGDIAGDTWNTSK
VRATLLGISPATQARVKIVTYGNVTYVMGILTPEEQAQITQKVSTTVGVQKVITLYQNYVQR
Epitope Information
IEDB Linear Epitope