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skp

General Information
Protegen ID 276
VO ID VO_0010918
Taxonomy ID 727
Other Database IDs CDD:225381
CDD:182724
Molecule Role Protective antigen
Molecule Role Annotation OMP26 was used to immunize rats via intestinal Peyer's patches, followed by an intratracheal boost. Immunization was found to significantly enhance bacterial clearance following pulmonary challenge with both the homologous NTHI strain and a different NTHI strain (Kyd and Cripps, 1998).
Related Vaccines(s) H. influenzae Omp26 protein vaccine
References
Kyd and Cripps, 1998: Kyd JM, Cripps AW. Potential of a novel protein, OMP26, from nontypeable Haemophilus influenzae to enhance pulmonary clearance in a rat model. Infection and immunity. 1998; 66(5); 2272-2278. [PubMed: 9573117].
Gene Information
Gene Name skp
NCBI Nucleotide GI 4574245
Genbank Accession AF109085
DNA Sequence 
>gi|4574245|gb|AF109085.1| Haemophilus influenzae NTHI-289 outer membrane protein 26 (skp) gene, complete cds
ATGAAAAACATCGCAAAAGTAACCGCACTTGCTTTAGGTATTGCACTTGCTTCAGGCTATGCTTCCGCTG
AAGAAAAAATTGCTTTCATTAATGCAGGTTATATTTTTCAACATCACCCAGATCGCCAAGCGGTAGCAGA
TAAACTTGATGCTGAATTTAAACCTGTAGCTGAGAAATTAGCAGCAAGCAAAAAAGAAGTTGATGATAAA
ATTGCTGCTGCTCGTAAAAAAGTAGAAGCAAAAGTTGCGGCTTTAGAAAAAGATGCACCTCGCTTACGTC
AAGCTGATATTCAAAAACGCCAAGAAGAAATTAATAAATTAGGTGCGGCTGAAGATGCTGAATTACAAAA
ATTAATGCAAGAACAAGATAAAAAAGTTCAAGAATTCCAAGCTCAAAATGAAAAACGTCAAGCTGAAGAA
CGTGGTAAATTATTAGATAGCATTCAAACTGCGACAAATAATTTAGCAAGAGCAAAAGGTTATACTTATG
TGCTTGATGCAAATTCAGTTGTATTTGCGGTAGAGGGTAAAGATATTACTGAAGAAGTATTAAAATCTAT
CCCTGCTTCTGAAAAAGCACAAGAGAAAAAATAATAGGTTC
Protein Information
Protein Name outer membrane protein 26
NCBI Protein GI 4574246
Protein Accession AAD23967.1
Protein pI 7.75
Protein Weight 20936.21
Protein Length 264
Protein Note Periplasmic chaperone for outer membrane proteins, Skp family [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones]; COG2825
Protein Sequence 
>AAD23967.1 outer membrane protein 26 [Haemophilus influenzae]
MKNIAKVTALALGIALASGYASAEEKIAFINAGYIFQHHPDRQAVADKLDAEFKPVAEKLAASKKEVDDK
IAAARKKVEAKVAALEKDAPRLRQADIQKRQEEINKLGAAEDAELQKLMQEQDKKVQEFQAQNEKRQAEE
RGKLLDSIQTATNNLARAKGYTYVLDANSVVFAVEGKDITEEVLKSIPASEKAQEKK
Epitope Information
IEDB Linear Epitope