VIOLIN: Vaccine Investigation and Online Information Network

Tbp2

General Information

Protegen ID

277

Sequence Strain (Species/Organism)

Haemophilus influenzae 86-028NP

VO ID

VO_0010865

Taxonomy ID

281310

Molecule Role

Protective antigen

Molecule Role Annotation

Recombinant Tbp1 and Tbp2 proteins were expressed from Escherichia coli and antisera were raised to the purified proteins. In a passive model of bacteraemia, infant rats were protected from challenge with Hib after transfer of anti-rTbp2 antiserum, but not after anti-rTbp1 antiserum (Loosmore et al., 1996).

References

Loosmore et al., 1996: Loosmore SM, Yang YP, Coleman DC, Shortreed JM, England DM, Harkness RE, Chong PS, Klein MH. Cloning and expression of the Haemophilus influenzae transferrin receptor genes. Molecular microbiology. 1996; 19(3); 575-586. [PubMed: 8830248].

Gene Information

Gene Name

Tbp2

NCBI Gene ID

3430457

Genbank Accession

CP000057

Locus Tag

NTHI1169

Gene Starting Position

1117518

Gene Ending Position

1119410

DNA Sequence

>NC_007146.2:1117518-1119410 Haemophilus influenzae 86-028NP, complete genome
TCTACTTGTTGGTTTTTTCTACTTGTCTTTTAGCTCCAAAGACAACTGCAGCTCTTGCATTTGGTGAATT
GGGTGGTGAAGGTACGGTTGAGGAACTTTCAGAATTTGTAGCTGTAGGATTGTTTCCGTTATAGGTGAAA
TAACCGCCTAATTCTGTAGCGTGCGGACCATAAAATGCCCCGTTTACTGTTGTCGTGAAATTGACTTTAG
ATGTGGCTTGTGTATTTTTGGGATCAATCACTACATTTGCGGTTGCTTTACCTTCGAAGGCATTACTACC
ATTTTTAAAGGTTGCCTCAATGTTAAACACGGTATTTTGTGAGTCGGCTCGTTTTAATTTGCCTGTTAAT
GTTTTATTGTCAAAATTGACATCAAACTCGGCGGGAGCATTTTTATCTTGTTGTTTATTTCCTGTAGTGG
AGTAAGATGTCTTGTCATCACCAATATAACCAAACCAACTACCGAGATATTTCACGTTTCCCGTTACAGG
AATTTGAGAACTGGGAGTACGGAGACCTAACAAAAATTGGTGGTATTGTCCTGTTTGATTTGTGTTTTTC
TTCTCTTTATCCTCATAATACATACCAAATTTTACATAGCTTAGATTCTTGCAACATGCTTCTACTTTAT
AGGTTTTATTTCCAATATCGTGATGTTTACTCGTTACGAAGTCATCAGTATCCCCTTCAGGGAAAAGAGG
AACAGGGTAATTATCAATTAAAAGGTAATCAGCTTCACCAAAACTTGATATATCTTTTGTCGTAAAGTTT
TTTTCATCGGTTTTTACATCGGCTGTTGTACTGGCTGTTGTACTGGTTGTTGCATCGGCTGTTTTAGTAG
AGAAAGTAATTAGCTTGCCATCAATTAAGGTTTCTTTGGATAATTTTTCCTTTTCTGTTTCTGGCGTTTC
TTTGGCACTAAATACCCCAAAAACTCGTTTATCCCTAGCTAAGAATTTACCCCCTAGTTCTTCAGCATTA
GGTCCATAAAAACCACCTTCTAATGTTCCCTCGCTGGTAAAGGGATGTTCATCCGATGTGGATTTCGTAG
GAGTAACTTTACCCCTGAATCTATTACTATAAATATGGGCATCTATATCATAGAGTTTTTCCTTTTCATA
TTGTTGAATATCAGTTTTTCTTTTGGTGTAAGACAGTTGTCCTGTCAGTTTTTTAGTCCCAAAATCTGCA
CTAAATTCACTTATTAAGCCTATATCACCATTCTTTGAATTATTTTCTAAATCAATATCTCCTCGAGTAG
CACTACGTCGAAAATAAGCTTGACCTCTAGCATTACTGAACAAAGAATAATTTTGGCCATATTTAGTTGC
AGTGATGAAATCCCAAGTTCCTTTATACGTTGCTACACCGCTTACTGGCAAGTCTGTTGCAGTTTTATTA
CCATAATAAAACGCATAACCATAATGGCCACTATAGGCTTTTTTTTCTGTTGCTAATTTGGAAAAGTCTT
TCCAATTCTCAATATAGTACAAACCAGAATAAACGTATTTTTGTAAATTGGGGTCTTGTAATGCTCTATT
AGGTTCAAGCCCAATTGGATTTGTATGTATTTTATTTTCTGTTTTAACATTTTTAACATCATCTTCAATC
GTAGAAGGTGAGGAAAAATATGATATATAGCCATTTTCATTTAAGAAACTAGGTTCTTTATTACCACTCA
GATTCTGAGCCACTAACTTCATCCCTCCTCCTAAAGAAGGAATGGACAACTTTTCCAAATTAGATTTTGT
TCTTGAACTTGAAGTATCGTCTTGATAACGTGGTTTAGAAGAGGAGGGATTAGAGACGTCATCTACATCA
AAAGAACCACCTCCCCCGCTACAAGCGCTTAATAAAAAGGAAAGTCCACCAGTGATAAGAGGTACAGATT
TCA

Protein Information

Protein Name

transferrin-binding protein 2

NCBI Protein GI

68249580

Protein Accession

YP_248692

Protein pI

8.28

Protein Weight

66447.12

Protein Length

630

Protein Note

Similar to: HI0995, TBP2_HAEIN

Protein Sequence

>YP_248692.1 transferrin-binding protein 2 [Haemophilus influenzae 86-028NP]
MKSVPLITGGLSFLLSACSGGGGSFDVDDVSNPSSSKPRYQDDTSSSRTKSNLEKLSIPSLGGGMKLVAQ
NLSGNKEPSFLNENGYISYFSSPSTIEDDVKNVKTENKIHTNPIGLEPNRALQDPNLQKYVYSGLYYIEN
WKDFSKLATEKKAYSGHYGYAFYYGNKTATDLPVSGVATYKGTWDFITATKYGQNYSLFSNARGQAYFRR
SATRGDIDLENNSKNGDIGLISEFSADFGTKKLTGQLSYTKRKTDIQQYEKEKLYDIDAHIYSNRFRGKV
TPTKSTSDEHPFTSEGTLEGGFYGPNAEELGGKFLARDKRVFGVFSAKETPETEKEKLSKETLIDGKLIT
FSTKTADATTSTTASTTADVKTDEKNFTTKDISSFGEADYLLIDNYPVPLFPEGDTDDFVTSKHHDIGNK
TYKVEACCKNLSYVKFGMYYEDKEKKNTNQTGQYHQFLLGLRTPSSQIPVTGNVKYLGSWFGYIGDDKTS
YSTTGNKQQDKNAPAEFDVNFDNKTLTGKLKRADSQNTVFNIEATFKNGSNAFEGKATANVVIDPKNTQA
TSKVNFTTTVNGAFYGPHATELGGYFTYNGNNPTATNSESSSTVPSPPNSPNARAAVVFGAKRQVEKTNK

Epitope Information

IEDB Linear Epitope