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Hma

General Information
Protegen ID 278
Sequence Strain (Species/Organism) Escherichia coli CFT073
VO ID VO_0010984
Taxonomy ID 199310
Molecule Role Protective antigen
Molecule Role Annotation A vaccine made by Hma from E. coli strain CFT073 and 536 induced protection to the infection of virulent strain CFT073 and 536, respectively, in the bladder in the CBA/J mice. (Alteri et al., 2009).
COG COG4771P, under P: Inorganic ion transport and metabolism
Related Vaccines(s) E. coli Hma protein vaccine
References
Alteri et al., 2009: Alteri CJ, Hagan EC, Sivick KE, Smith SN, Mobley HL. Mucosal immunization with iron receptor antigens protects against urinary tract infection. PLoS pathogens. 2009; 5(9); e1000586. [PubMed: 19806177].
Gene Information
Gene Name Hma
NCBI Gene ID 1037732
Genbank Accession AE014075
Locus Tag c2482
Gene Starting Position 2322323
Gene Ending Position 2324470
DNA Sequence 
>NC_004431.1:2322323-2324470 Escherichia coli CFT073, complete genome
AATGTTATATAATATACCTTGTCGAATTTATATCCTTTCCACTCTGTCATTATGCATTTCTGGGATAGTT
TCTACTGCAACCGCAACTTCTTCAGAAACAAAAATCAGCAACGAAGAGACGCTCGTCGTGACCACGAATC
GTTCGGCAAGCAACCTTTGGGAAAGCCCGGCGACTATACAGGTTATTGACCAACAAACATTGCAGAACTC
CACCAATGCCTCCATAGCCGATAATTTGCAGGACATCCCCGGAGTAGAGATAACAGACAACTCCTTGGCA
GGCCGTAAACAAATCCGCATTCGTGGCGAAGCATCCTCCCGTGTTTTAATTCTCATTGATGGTCAGGAGG
TAACTTATCAGCGCGCCGGAGATAATTATGGTGTGGGACTGTTGATAGATGAGTCTGCGCTGGAGCGTGT
TGAGGTAGTGAAAGGTCCATATTCCGTACTGTACGGTTCACAGGCAATTGGCGGTATTGTTAACTTCATA
ACCAAAAAGGGAGGTGACAAACTTGCATCTGGAGTTGTGAAAGCTGTTTATAATTCCGCAACAGCAGGCT
GGGAAGAATCAATCGCGGTCCAGGGGAGCATCGGTGGATTTGATTATCGCATCAACGGTAGTTATTCTGA
TCAGGGCAATCGTGATACGCCGGATGGACGTCTGCCGAATACCAACTATCGTAACAATAGTCAGGGTGTA
TGGTTGGGTTATAACTCCGGAAACCATCGTTTTGGCCTCTCGCTTGATCGCTACAGACTCGCGACGCAAA
CTTACTATGAGGATCCAGACGGAAGCTATGAGGCATTTAGTGTCAAAATACCTAAACTTGAACGAGAGAA
AGTTGGGGTATTCTATGACACAGACGTGGACGGTGACTATCTAAAAAAAATTCATTTCGACGCGTATGAG
CAGACCATCCAGCGCCAATTTGCCAACGAAGTAAAAACGACACAGCCTGTTCCCAGTCCGATGATTCAGG
CTCTGACCGTTCATAACAAGACTGACACCCATGATAAGCAATACACTCAGGCGGTCACATTGCAGAGTCA
CTTTTCGCTGCCTGCTAATAATGAACTTGTTACCGGTGCACAGTACAAACAAGACAGGGTCAGCCAAAGG
TCCGGTGGCATGACCTCAAGCAAATCTCTGACCGGCTTCATTAATAAGGAAACACGAACTCGCTCCTATT
ATGAGTCAGAGCAAAGTACAGTCTCACTATTCGCACAAAATGACTGGCGATTCGCCGATCACTGGACATG
GACAATGGGAGTTCGCCAATACTGGCTTTCTTCAAAGTTGACGCGTGGTGACGGAGTATCATATACCGCA
GGCATTATAAGCGATACCTCTCTTGCCAGAGAGTCTGCGAGTGATCACGAAATGGTAACATCTACAAGCC
TGCGCTATTCAGGTTTCGATAACTTGGAGTTACGCGCTGCGTTCGCGCAAGGCTACGTATTTCCCACACT
CTCCCAGCTTTTTATGCAGACATCTGCGGGCGGCAGTGTCACATACGGAAATCCTGATCTTAAGGCTGAA
CACTCCAATAACTTTGAATTAGGTGCACGATATAATGGTAATCAGTGGCTGATTGACAGCGCAGTTTACT
ACTCAGAAGCTAAAGATTATATTGCAAGTCTGATCTGTGATGGCAGTATAGTTTGCAATGGTAACACCAA
CTCCTCCCGTAGTAGCTACTATTATTATGACAATATTGATCGGGCAAAAACATGGGGACTGGAAATAAGC
GCGGAATATAATGGCTGGGTTTTCTCGCCATATATCAGTGGCAATTTAATTCGTCGGCAATATGAAACTT
CAACATTAAAAACAACTAATACAGGAGAACCAGCGATAAACGGACGTATAGGGCTGAAACATACTCTTGT
GATGGGTCAGGCCAACATAATCTCTGATGTTTTTATTCGTGCTGCCTCTAGTGCAAAAGATGACAGTAAC
GGTACCGAAACAAATGTTCCGGGCTGGGCCACTCTCAACTTTGCAGTAAATACAGAATTCGGTAACGAGG
ATCAGTACCGGATTAACCTAGCACTCAATAACCTGACAGACAAACGCTACCGTACAGCACATGAAACTAT
TCCTGCAGCAGGTTTTAATGCAGCTATAGGTTTTGTATGGAATTTCTG
Protein Information
Protein Name outer membrane receptor for iron compound or colicin
NCBI Protein GI 26248334
Protein Accession NP_754374
Protein pI 5.31
Protein Weight 75008.63
Protein Length 715
Protein Note Escherichia coli O157:H7 ortholog: z3159
Protein Sequence 
>NP_754374.1 outer membrane receptor for iron compound or colicin [Escherichia coli CFT073]
MLYNIPCRIYILSTLSLCISGIVSTATATSSETKISNEETLVVTTNRSASNLWESPATIQVIDQQTLQNS
TNASIADNLQDIPGVEITDNSLAGRKQIRIRGEASSRVLILIDGQEVTYQRAGDNYGVGLLIDESALERV
EVVKGPYSVLYGSQAIGGIVNFITKKGGDKLASGVVKAVYNSATAGWEESIAVQGSIGGFDYRINGSYSD
QGNRDTPDGRLPNTNYRNNSQGVWLGYNSGNHRFGLSLDRYRLATQTYYEDPDGSYEAFSVKIPKLEREK
VGVFYDTDVDGDYLKKIHFDAYEQTIQRQFANEVKTTQPVPSPMIQALTVHNKTDTHDKQYTQAVTLQSH
FSLPANNELVTGAQYKQDRVSQRSGGMTSSKSLTGFINKETRTRSYYESEQSTVSLFAQNDWRFADHWTW
TMGVRQYWLSSKLTRGDGVSYTAGIISDTSLARESASDHEMVTSTSLRYSGFDNLELRAAFAQGYVFPTL
SQLFMQTSAGGSVTYGNPDLKAEHSNNFELGARYNGNQWLIDSAVYYSEAKDYIASLICDGSIVCNGNTN
SSRSSYYYYDNIDRAKTWGLEISAEYNGWVFSPYISGNLIRRQYETSTLKTTNTGEPAINGRIGLKHTLV
MGQANIISDVFIRAASSAKDDSNGTETNVPGWATLNFAVNTEFGNEDQYRINLALNNLTDKRYRTAHETI
PAAGFNAAIGFVWNF
Vaxign Prediction
Localization(Probability) Outer Membrane
(Prob.=1)
Adhesin Probability 0.770
Trans-membrane Helices 0
Detailed Vaxign Results Vaxign Results
Epitope Information
IEDB Linear Epitope