VIOLIN: Vaccine Investigation and Online Information Network

TPBG

General Information

Protegen ID

291

Sequence Strain (Species/Organism)

Homo sapiens

Taxonomy ID

9606

Molecule Role

Protective antigen

Molecule Role Annotation

In a pre-clinical murine model, the recombinant virus expressing the tumor associated antigen 5T4 (TPBG) induces protection against challenge with CT26–h5T4 (a syngeneic tumor line expressing h5T4). Anti-tumor activity is long lived, with protection still evident 6 months after the final vaccination. In a therapeutic setting, injection of mice with TroVax results in a reduction in tumor burden of >90% (Harrop et al., 2006).

Related Vaccines(s)

Recombinant Human Papillomavirus Nonavalent Vaccine , Recombinant Modified Vaccinia Ankara-5T4 Vaccine

References

Harrop et al., 2006: Harrop R, Ryan MG, Myers KA, Redchenko I, Kingsman SM, Carroll MW. Active treatment of murine tumors with a highly attenuated vaccinia virus expressing the tumor associated antigen 5T4 (TroVax) is CD4+ T cell dependent and antibody mediated. Cancer immunology, immunotherapy : CII. 2006; 55(9); 1081-1090. [PubMed: 16311730].

Gene Information

Gene Name

TPBG

NCBI Gene ID

7162

Genbank Accession

AJ012159

Chromosome No

Gene Starting Position

82363205

Gene Ending Position

82367416

DNA Sequence

>NC_000006.12:82363205-82367416 Homo sapiens chromosome 6, GRCh38.p12 Primary Assembly
CTTTCTCTCTCTCTCTCTCTTAAAGTTGGCGCGCTCTCTTCACAAGTTCCATCACTACCCAAGAAGTGAG
GGGGCGGGGGGGACAGGCGGGAAGGCATTAATTACACCTAAATCTGAAGTTTGCGGCCTCAAGTACCACT
TTGATGGGGAGAGCTTCTGAAGCTTCCATACAACCTGCCGTGCCTTTGCTGCTGCCGCAGTAGATTTTCA
GCTCATTTCTTTCTGCTGCTGCTTCGCGCTGCTCTGTCATGCCTAAATCTATCTCGTCACTGCCAAAGGT
GCCTGAATCAGGGTGAATTCCACGAGATTCACCAGCGGTTTTGCTCCAGTCCAAGGTAAATACAGTATGC
AAAATGAGGAACCACCCAAGGATGTCGGGGAGGGGGGAGAGAAAGGGATTCCCTCACCTTTTCCGGCACA
TTCCTCGTTAATTTCCACCAGGAGGAGGCGCGCAGCCCAGCTCCCCTAGTCTCTCTTCTTAAATCCCCCT
ACCTACGGCTGCCGAGGTTGGCCGCGCGTCGGGAATCTCCCCGACAGTCCTGGCCCTCCCCCGCCCCCCG
GGTTGGTTTTTCCCAGCTGCGGAGGTTGGGAGGTTGGGCCAGGGGCTGGGGTGCGAAGAGAGTCGGCGCC
CGCAACGCGGAGCCGGGAAGTCGTCGCTACTCTGGTGGAACTCAGAGTTGGTTCTGGAGGCGGCGGACGC
GGAGGTGAGCAGTGGGAGCCCGCGGCCTGGGAGAGACCCGGGAGGCGTCGTTGGGGCCCCTCCCCATCCT
CGGGTGGAGAGTAGGGTTGGTTCGGGTTGCCACTGTACCCCGAGTCCCACTGCTGCTTTGTTCCCAGACT
CTCCCCTCCTCTTTGGAGATGACTTGAACCCCTTTGAGATCCGAGGGGCTGGCGGGGCGCGGGCTGGGGG
GCGACAGTTGTAGCTCCACTTCCTGCTAATGCGAGAAGGTACAAAAAGAGATCAAAAAGTCCTGTAACCT
GAAACTTCCCTCGCATCCTAACCGGGACCTGGTGGAGAGGTCTGGGCGGGGGCGGAGACACCCGGAGGCC
GACCTTCCGCCGAGGCGGTGCAGGAAGGAACGGGAGAGGGAGAAGTTTGGTAGGGAAGGAATTGGGGATT
AAGCGGTAAGTTAGACGCGGGAGACGAGTCTCCTCGGGAAAGGCGGAGGGCGGGAGGCCGGTCGGGTTTA
TTTAGTGTGGGCCAGGGAAGAAGGAAGACTTTGCGGTCTGGGTGTCGGATGCGCGTCCCCCTCCGGAGTA
AAAGTGACCGGAGGGGTTGGGGAGGCGAGGCCGGGGCGGGCTTTTGGAAGGAGGTCTCTGGGACAGACTG
GAGACGACTAGACTCGAAAAGGCCGGTTTTTGCACTCCGGAAGCCGCGGCAGCCACCGCTGTTCACGCCT
CTCTCCTGCTTGTCCCAGGTCCCTCAGAGGATCCAGCGAGGGGCGCCAACAAGAGGCGAAGAGGTGGCAC
CAGGGCGGCGGCAGGAAGAGGAGCGGGAGCAGGAGCGCGGAGCGGAGCGTCCCGACCCGCCGTGCGTACT
TTCTGGAGGGAAGGGGCGGGGGAATCGGCCCCTGAGGGAAGCGCCCGGTGGCGAGGGGGTTAGCCAAGTT
CCGGCTGCGGCGCCACTCCCTCGGTTCCACGAGAGGAAAGTTTTTTTTTTCCAGACGCTTCCGCCGGCTC
GCGCCCTCCGGGCCCAGCCTCCCGAGCCTTCGGAGCGGGCGCCGTCCCAGCCCAGCTCCGGGGAAACGCG
AGCCGCGATGCCTGGGGGGTGCTCCCGGGGCCCCGCCGCCGGGGACGGGCGTCTGCGGCTGGCGCGACTA
GCGCTGGTACTCCTGGGCTGGGTCTCCTCGTCTTCTCCCACCTCCTCGGCATCCTCCTTCTCCTCCTCGG
CGCCGTTCCTGGCTTCCGCCGTGTCCGCCCAGCCCCCGCTGCCGGACCAGTGCCCCGCGCTGTGCGAGTG
CTCCGAGGCAGCGCGCACAGTCAAGTGCGTTAACCGCAATCTGACCGAGGTGCCCACGGACCTGCCCGCC
TACGTGCGCAACCTCTTCCTTACCGGCAACCAGCTGGCCGTGCTCCCTGCCGGCGCCTTCGCCCGCCGGC
CGCCGCTGGCGGAGCTGGCCGCGCTCAACCTCAGCGGCAGCCGCCTGGACGAGGTGCGCGCGGGCGCCTT
CGAGCATCTGCCCAGCCTGCGCCAGCTCGACCTCAGCCACAACCCACTGGCCGACCTCAGTCCCTTCGCT
TTCTCGGGCAGCAATGCCAGCGTCTCGGCCCCCAGTCCCCTTGTGGAACTGATCCTGAACCACATCGTGC
CCCCTGAAGATGAGCGGCAGAACCGGAGCTTCGAGGGCATGGTGGTGGCGGCCCTGCTGGCGGGCCGTGC
ACTGCAGGGGCTCCGCCGCTTGGAGCTGGCCAGCAACCACTTCCTTTACCTGCCGCGGGATGTGCTGGCC
CAACTGCCCAGCCTCAGGCACCTGGACTTAAGTAATAATTCGCTGGTGAGCCTGACCTACGTGTCCTTCC
GCAACCTGACACATCTAGAAAGCCTCCACCTGGAGGACAATGCCCTCAAGGTCCTTCACAATGGCACCCT
GGCTGAGTTGCAAGGTCTACCCCACATTAGGGTTTTCCTGGACAACAATCCCTGGGTCTGCGACTGCCAC
ATGGCAGACATGGTGACCTGGCTCAAGGAAACAGAGGTAGTGCAGGGCAAAGACCGGCTCACCTGTGCAT
ATCCGGAAAAAATGAGGAATCGGGTCCTCTTGGAACTCAACAGTGCTGACCTGGACTGTGACCCGATTCT
TCCCCCATCCCTGCAAACCTCTTATGTCTTCCTGGGTATTGTTTTAGCCCTGATAGGCGCTATTTTCCTC
CTGGTTTTGTATTTGAACCGCAAGGGGATAAAAAAGTGGATGCATAACATCAGAGATGCCTGCAGGGATC
ACATGGAAGGGTATCATTACAGATATGAAATCAATGCGGACCCCAGATTAACGAACCTCAGTTCTAACTC
GGATGTCTGAGAAATATTAGAGGACAGACCAAGGACAACTCTGCATGAGATGTAGACTTAAGCTTTATCC
CTACTAGGCTTGCTCCACTTTCATCCTCCACTATAGATACAACGGACTTTGACTAAAAGCAGTGAAGGGG
ATTTGCTTCCTTGTTATGTAAAGTTTCTCGGTGTGTTCTGTTAATGTAAGACGATGAACAGTTGTGTATA
GTGTTTTACCCTCTTCTTTTTCTTGGAACTCCTCAACACGTATGGAGGGATTTTTCAGGTTTCAGCATGA
ACATGGGCTTCTTGCTGTCTGTCTCTCTCTCAGTACAGTTCAAGGTGTAGCAAGTGTACCCACACAGATA
GCATTCAACAAAAGCTGCCTCAACTTTTTCGAGAAAAATACTTTATTCATAAATATCAGTTTTATTCTCA
TGTACCTAAGTTGTGGAGAAAATAATTGCATCCTATAAACTGCCTGCAGACGTTAGCAGGCTCTTCAAAA
TAACTCCATGGTGCACAGGAGCACCTGCATCCAAGAGCATGCTTACATTTTACTGTTCTGCATATTACAA
AAAATAACTTGCAACTTCATAACTTCTTTGACAAAGTAAATTACTTTTTTGATTGCAGTTTATATGAAAA
TGTACTGATTTTTTTTTAATAAACTGCATCGAGATCCAACCGACTGAATTGTTAAAAAAAAAAAAAATAA
AGATTCTTAAAAGAATTACAGTGTGTGCAAGTTTGCTTTGAAAAAAGGATGAAGGGCAGGAGTATTCAAT
GGTCTTGGTTCCGATGATAATTATTACTTAACATAGCTGAGAATCAAACTGTAGCAATGTCTAATATAAA
TAGACTTGGGAGATCGTTTTGAAATGGTGGATCCTTTTAGTATTTAAATGGAGAGTTTGAGTATTCATGT
GACTGTATGGTCCCAAAGTTAATGCTATTTATGAAACAGTTTTGTAAGAACATAATGAAGTTGGTAAAAG
CTAAGCGTTCTGCACAATAAACAGTTCCCAGTTTGGGGCTTTTTCAAGGCTAATGAAGTTATTGTTGGTC
TAGAAAAATAGTATTTACTTAATAAAACTCTGTTTGAAATTGTTCTGTGGATTTTTAGAGCAGAATTTGA
AACAAATGTAATGCAAATAAATATAAAGATAAAGTGTCTTAAAGACAATATTCTGAAATAAAAGATATAA
AATATAATTTAA

Protein Information

Protein Name

transcript variant 1

NCBI Protein GI

262205665

Protein Accession

NP_001159864

Protein pI

6.83

Protein Weight

43252.68

Protein Length

420

Protein Sequence

>NP_001159864.1 trophoblast glycoprotein precursor [Homo sapiens]
MPGGCSRGPAAGDGRLRLARLALVLLGWVSSSSPTSSASSFSSSAPFLASAVSAQPPLPDQCPALCECSE
AARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFARRPPLAELAALNLSGSRLDEVRAGAFEH
LPSLRQLDLSHNPLADLSPFAFSGSNASVSAPSPLVELILNHIVPPEDERQNRSFEGMVVAALLAGRALQ
GLRRLELASNHFLYLPRDVLAQLPSLRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAE
LQGLPHIRVFLDNNPWVCDCHMADMVTWLKETEVVQGKDRLTCAYPEKMRNRVLLELNSADLDCDPILPP
SLQTSYVFLGIVLALIGAIFLLVLYLNRKGIKKWMHNIRDACRDHMEGYHYRYEINADPRLTNLSSNSDV

Epitope Information

IEDB Linear Epitope