VIOLIN: Vaccine Investigation and Online Information Network

ERBB2

General Information

Protegen ID

296

Sequence Strain (Species/Organism)

Homo sapiens

Taxonomy ID

9606

Molecule Role

Protective antigen

Molecule Role Annotation

Three peptides representing B-cell epitopes of the extracellular domain of Her-2/neu each of them inducing Her-2/neu specific immune responses with anti-tumor activity in vitro were identified. A study was performed to evaluate the in vivo protective capacity of a combined vaccination with these three peptides in FVB/N transgenic mice spontaneously developing c-neu overexpressing breast cancers. The three Her-2/neu peptides coupled to tetanus toxoid were administered with or without addition of recombinant IL-12. At the time all untreated mice had developed tumors about 40% of peptide-immunized mice and nearly 60% of mice immunized with the peptide vaccine co-applied with IL-12 remained tumor free (Wagner et al., 2007).

Related Vaccines(s)

Adenovirus Encoding Rat HER-2/neu , Adenovirus HER2-Transduced Autologous Dendritic Cell Vaccine , AE37 Peptide/GM-CSF Vaccine , Allogeneic Cellular Vaccine 1650-G , Allogeneic GM-CSF-Secreting Breast Cancer Vaccine , Anti-HER2/HER3 Dendritic Cell Vaccine , Autologous GM-CSF-Secreting Breast Cancer Vaccine , Autologous Ovarian Tumor Cell Lysate-Pulsed Dendritic Cell Vaccine , Cancer Her-2/neu Protein Subunit Vaccine , CD80 Breast Cancer Vaccine , EP-2101 Vaccine , HER2 ECD+TM Virus-like Replicon Particles Vaccine AVX901 , HER2-pulsed Autologous Type-1 Polarized Dendritic Cell Vaccine , HLA-A*0201-Restricted TRP2-gp100-EphA2-HER2 multipeptide Vaccine , Lapuleucel-T Vaccine , Malignant Glioma Tumor Lysate-Pulsed Autologous Dendritic Cell Vaccine , Mammaglobin-A DNA Vaccine , Melan-A/MAGE-3.DP4 Peptide Vaccine , Modified Vaccinia Ankara (Bavarian Nordic)-HER2 Vaccine , Monoclonal Antibody 4B5 Anti-Idiotype Vaccine , Multi-glioblastoma-peptide-targeting Autologous Dendritic Cell Vaccine ICT-107 , MVF-HER-2(597-626)/MVF-HER-2 (266-296) Peptide Vaccine , Nelipepimut-S Plus GM-CSF Vaccine , pNGVL3-hICD Vaccine , Poly Microsphere Encapsulated HER2/neu Oral Vaccine , pUMVC3-IGFBP2-HER2-IGF1R Plasmid DNA Vaccine , Recombinant dHER2 Vaccine , Survivin/p53/HER2 Antigen-loaded Autologous Dendritic Cell Vaccine

References

Wagner et al., 2007: Wagner S, Jasinska J, Breiteneder H, Kundi M, Pehamberger H, Scheiner O, Zielinski CC, Wiedermann U. Delayed tumor onset and reduced tumor growth progression after immunization with a Her-2/neu multi-peptide vaccine and IL-12 in c-neu transgenic mice. Breast cancer research and treatment. 2007; 106(1); 29-38. [PubMed: 17203384].

Gene Information

Gene Name

ERBB2

NCBI Gene ID

2064

Genbank Accession

AB025285

Chromosome No

Locus Tag

RP23-355L10.8

Gene Starting Position

39688083

Gene Ending Position

39728661

DNA Sequence

>NC_000017.11:39688083-39728661 Homo sapiens chromosome 17, GRCh38.p12 Primary Assembly
GAAGTTCCTGTGTTCTTTATTCTACTCTCCGCTGAAGTCCACACAGTTTAAATTAAAGTTCCCGGATTTT
TGTGGGCGCCTGCCCCGCCCCTCGTCCCCCTGCTGTGTCCATATATCGAGGCGATAGGGTTAAGGGAAGG
CGGACGCCTGATGGGTTAATGAGCAAACTGAAGTGTTTTCCATGATCTTTTTTGAGGTAGGGCTGTTTAC
TGTCACCACCCCTGTCGGATTTTACTTCCTAAACGTACCTGTAACTATCCACTTCTCTCCATCTCTTCTG
GCACCACCCTGGTTAAAGACACCATCATGTGTCGCCAAGACAGCCGCAGTAGCTTCTTAATGGCTCTCCC
TGCCTCTACTTTTGCCTCTTCCAACCTGCGCTCCATTTTGAAAAATTAAAATTTGCCCATATCACTTTTT
TTTTCTTAAAATTATTTACTGGCTCCCAATTACCTTGGGTAAAATACAGTCTCCACAAACCCTGCCTGAT
TTGGCCCCTGTCCACTGGTCTCCCTCACTCCCTTGCTCCAGACCCGCTTCAGAGGGCTATGTCCCTCAAG
CTTCCTGACTGCCTGGCCTGGTCTGAATCACTCACTCTTCTTTTTTCTTCTAGTCGCAATTGAAGTACCA
CCTCCCGAGGGTGATTGCTTCCCCATGCGGGGTAGAACCTTTGCTGTCCTGTTCACCACTCTACCTCCAG
CACAGAATTTGGCTTATGGTAGGCGCTAACTGCGTTTGTTTGTTCTTCTGTTTAATGAATGAACAGCATA
CATCAACATAAGAACTTGACAAATCCAGGGCTGTAAAATCATCAGTATGGTTCTGCACTGAGATCGGAGA
GAAGTAATATTTCTAGGAAAATTAGGAACCCTGGGAACAGGACGCTTGCTTTAGTATCCTCTCCCTGCTC
ACCTCCCCTGCACTCCCATCAGCACCGACCCACACCCAATCTCATAGAAGCCTTGTAGCTAAGGATCACC
CTTTCTCCTCCCCCACTCTCCTCACCCCTTGTCAACTTTTCTTTTTCGTCCTGGGGGTTGGAATGAGTAA
GAAGTAGCCTGGGATTCCATTCACTCACTTAACAAACATTTCTGAGTCCTTAGCTCTAGCACCTTGCTAA
GCAAGGCAAAATCTCCAGGAGGCACCATTCACATTGCATTTTCTGTGAATGGTGCTCTGGGGAGCAGCAT
TCACATTGCCTTTTCTGTGAATGGCAAATTCTTCCAGTTAAATATAACATGAATAGTGTCCCCTGGAGTT
GACCACCCAACTGATACTGACTGAGAAGCTGAAATGAACAAAACAACCCCTTAGCCCTCCAGGAGCTGAC
CGGAAATCCAGTGCTAATACTACTTTGCATCTTACAGATTAGTTCTTTTACAATACTGTTTTTTTTTCTT
TTTTCATTTCATTTTGTCCTTTCTGTGACTCTGGGATGAGTCTTTTTATGAGGATCCTCATATAAAGATG
GACATTTAGGATTAAAGAGGATGAAATCCTGACAAAATAGGGAGTCTCCCCTTTAGAAAATTCCTAAGTA
AGGCTGGGGGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGACGGATCACCTGAG
GTTAGGAGTTTGAGACCAGCCTGACCAACATGGAGAAACCCCATCTCTACTAAAAATACAAAATTAGTTG
GGTGTGGTGGTGCATGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGG
GAGGCAGAGGTTGTGGTGAGCCAAGATTGCGCCATCGCACTCCAGCCTGGGCAACAAGAGCGAAACTCAA
AAAAAAAAAAAAAAAGAAAAAGAAAATTCCAATTTTGAAGGCCTCATCCTATATTATGTCAAACATACTG
AAATGCAGTAACGCCCCACATTAAATAAGATTTATAAATAACTATACATATATATAATTCAATCTAATTG
CTGTTAATAGTTGACATATTGCTACATTTATATACATTTAGTTAAAAAAAATTTTTTTTCCCAGACAGCC
TCTCACTCTTTCACCTAGACTGAAGTGCAGTGGCATGATCACGACTCACTGCAACCTCAACCTCCCAGAC
TCAAGTGATCCTTCCATCTCAGCCTCCTGAGTAGCTGGGACTGCAGCATGCGCCACTATGCCCTGCTAAT
TTTTTTAATTTTTTGTAGAGACACGGTCTTGCTATGTTGCCTAGACTGGTCTCCAATTCCTGGGCTCGAG
TGATCCTCCCGCCTCAACCTCCCAAAGTGCTGGGATTACGGGCGTGAGCCATGCCACACGGCCATAAAAT
ATTAATTTTCGCAGCTTTCTTATATTTTAGAACTAACAATGGAAATTTGTTCGGGTCTAAAGTATTTCAG
AGGTCCTTGAAAACCCATGCCTACATACCTGATGGAAAAAGCAATCCTAGGTTAATGGTGGAAGTGGGAG
TAGAGACTTCTGTTCTGTTGACTTCTTGGAAGATGGGGTACTGTCTCTCTGGGACAGCTCTTGAGAATTT
CCCTGCCAGCACAGCCCCAGATAACAATCTCTAGATGGCGATTACCTGGCCTCTCTTCCCAACTTTCTAG
CCTGGAGCCCCTAGTTCTCCCCTGAGCCTCCTTAGCTTGTCCTTCTTCCTAACTTGTATTTGGCTTCAGA
TGTGATCCACAGTCTGAAAAGTCACTAATTCATTCCTTCAACTCAGGCTTATTGAGTCCTCCTGTGTATC
AGCCATTGTACTCATGGGGGAAAAAAAAGACAAAGCATATGTTAATAGTAGAGTGTGCTGGACAGGCACA
GTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGGCGAGGCAGGTGGATCATCTGAGGTCAGGAGTTCG
AGACCAGCCTGACCTAACATGGAGAAACTCCTGAGATCGTGCCATTGCACTCCAGCCTGGGCAACAAGAG
CAAAACTCCGTTTCAAAAAAAAAAAAAAAAGTATAGTGTGCTAAAGGCTCAACGGCAAGCTGACCATGTT
CTTAGATCAAAATTGGTAGAGAGTCTACAATGTGGGTTCCTTATTCATCAAATGTTTATTAAGTTTACCA
TGTGCAAGTCTCTGGGAACAGAGTGATGAACAAGGCACTGTACTTTTCATGGTCAGAGGAGGGAAACAGG
CCATAAACAAGTGTCAAACAAAAGACTGAAGCCAGGTGCGGTGGCTCACATCTGTAATCCCAGCACTGTG
GGAGGCCAAGGCAGGCGGATCATGAGATCAGGAGATCGAGACCATCCTAGCCAACATGGTGAAACCCCAT
CTCTACTAAAAATACAAAAAAATTAGCTGGGCATGGTGGCACGTGCCTGTAATCCCAGCTACTCCGGAAG
CTGAGGCAGGAGAATTGCTTGAACCAGGGAGTTGGAGGTTGCAGTGAGCCTGGATTATGCCACTGCACTC
CAGCCTGGTGACAGAGCGAGACTCCATCTACATTAAAAAAAAAAATATATATATATATATATACACACAC
ACACACACACACACACACATACCCTCTAACCCAGGAATTTCACTCCTAGGTATACCTACATAAGCTCCAG
TATACCTAAACAAGTGCAAATTTGTTTAAGTACAGTTATTTGTGGTAGCATTAGTCATTGTTTTCAATAG
CAAGAAGAAAAAGGAAACAACTAAATGTCCATCAATAGGGAATGAATTATATTAATGGAGGGAGAGCCAT
ACAATGGAAGGCTGAACAGAAATTAATAGGAATGGGGCAGATTTGTAATGTACTAGCATGGTAAAACCTT
CATGATAGATATAGATATAGATATAGATATAGATATAGATATATATACATATACATATACATATACATAT
ACATATATATATATATATATATATATCTCTTGTGTCTCAGCCTCCCGAGTAGCTGGGATTACAGGTGTGT
GCCACCACATCCGGCTAATTTTTGTATTTTTTAGTAGAGACAGGGCTTCACCATGTTGGTAAGGCTGTCT
TGAACTCCCGACCTCAGGTGATCCACCTGTCTCAGCCTCCCAAAGTGCTGGGATTATAGGCATGAGCCAT
CACACCTGGCCAAATATTTTTGATAAGTATCAAGTGCACAGTGCAGAACAAAATATGTGTGTGTGTATGC
ATGTGTATGTACACCTATACACTTATATACAGTACCCCATGTGAAGAAAAATAAGGGTACGTGTTATGCG
CGTAGTATTATGGTTGTTATTTTTGAGAATATATCTAGAAAGATAAAAAAGAAAGTGGAAATAGTTCTTG
CCTCTGGTGGGAAGTGGGACTATGTGCCTGATCAATAGGGAAGTAAGGAACACTTTTTTTTTTTTTTTTT
AAACGGAGTTTTTGCTCTTGTTACCCAGGTTGGAGTGCAATGGCGCGATCTTAGCTCACTGCAACCTCTG
CCTCCCAGGTTCAAGCGATTCTGCTGCCTCAGCCTCCTGAGTAGCTGGGATTATAGGCATGCGCCTCCAC
GCCTGGCTAATTTTGTATTTTTAGTAAAGATGGGGTTTCTCCATGTTGGTCAGGCTGGTCTTGAACTCCC
CACCTCAGGTGATCCGTCCGCCTCAGCCTCCCAAAGTGCTAGGATTACAGGCGTGAGCCACCGTGCCTGG
CCAGGAACGCTTTTTATTTTTGTACCTTTAAAAGTGTGTACCGTCTGTGTATATAATCAGTTAAAAACAA
AGAAAAGCTGAGTGTGGTGGCTCATGCCTGTAATCCCAGCCCTTAAGGAGGCCGAGGCCGGCGGCAGATC
ACCTGAGGTCAGGAGTTCAAGACCGGCCTGACCAAAACGGTGAAAACTCATCTCTACAAAAACATAAAAA
TTAGCCAGGCATGATGGCAAGTGCCTGTAATCCCAGCTGGTTGGGAGGCTGAGGTGGGAGACTTGCTTGA
ACCTAGGAGGCAGAGATTGCAGTGAGCCAAGACTGTACCACTGCACTCCAGCCTGGGCAACAGAGCAAGT
CTCTGTCTCAAAACAAAAACAAAAACACAAAGAAAAAATGTAAAACAATTTCATGCAGTAGCAAGCATCG
AGTTAAATACAGTTGACCCTTGAACAACACAGGTTTGAATTGCACGGGTCCATTTATACTCACATTTCTT
CCACCTCTGCCACCCCCAAAATAGCAAGACCAACCCCATCTCTTTTCCTTTCTCTTCCCCCTCCTCAGCC
TACTCAATGTGAAGATGATGAGGATGAAAACCTTTGTGATGATCCACTTCCACTTAATGAATGGTAAATA
TGTTTTTTCTTACTTATGATTTTCTTAGTAGCATTTTCTTTTCTCTAGCTTCCTTTATTGTAAAAATACA
GTATATAACACATATCACATACAAAATGTGTGTAAATGGACTGTTTGCTATTGATAAGTATTCTGGTAAA
CAGTAGACTATTAGTTTTTTTTGTTTTGTGACAAGGTCTCCCTCTGTCGCCCAGCCTGGAATGCCGTGGT
GTGATCATGGCTCACTGCAGCCAAAAACTTCTGGGCTAAAGCAATCCTCTACTAAAAATACAAAAATTAG
CCAGGCATGGTGGTGCGCTTCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAACCC
GGGAGGCAGAGGTTGCAGTGAGCTGAGATTGCACCGTTGCATTCCAGCCTGGACAACAGAGCGAGACTCC
ATCTCGAAAATAAAATAATAATAATAATAATAATAATAATAATAATAATAATAGGGCTGGGTGTGGTGGC
TCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGACAGATCACCTGAGGTCAGGAGTCTCAATTA
AAAAATAAATAGGCCGGGCACAGTGGCTCATGCCCATAATCCCAGCACTTTGGGAGGCCGAGGTGGGCAG
ATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACACGGAGAAACGCTGCCTCTATCAAAAATACA
AAAATTAGCTGGATGTGGTGGTGCATGCTATAATCCCAGTAATACCAGCTACTCGGAAGGCTGAGGCAGG
AGAATCACTCGAATCCGGGACACGGAGGTTGCAGTGAGCCGACATCATGCCACTGCGCTCCAGCCTGGGT
GACAGTGAGACTCTGTCTCAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATATATATATATATAT
ATATATATATATATATATATATATATGTGTGTATATATATATATATACACATATATATGTGTATATATAT
ATACACACACACATATATATGTGTATATATAAAATAAAATAAATAATAATAAAACATTTACTTTGGCTGC
TGTTGCTGCGGGGAGAATTGCAGGGTGTCAAAAGTAGCACTGGTGGAGGGGTAGTGATCAAAGTCTGGTG
CTTTAGCCCAAAGGAGAAATGATAGAGACTCAGACTAGCTGGTGATGGAGGTAGAATAAGCATAAATGTA
TCAAAAAGAGGAGTTGATAGATCTTAAAGAATGATTGGATTTGAAGGGCAAAGGAAGAGAAGAATCAACC
AGGTGGGTTCAGTGAATGAAACCATCAGAAACGAATTGTCCCCTGAAATCAAGACTTTGTGATTGCCATA
GTTGTATGCTTCTCAAAGGTTCCTCGTCTCCTCTTCCTTGGACCAAAAGTCAGAGGCAAGAATGCCCTCA
TTCATACCCCAGTGGTCTATACCTCCAGCAGCAAGTCGAGTGAGCAAGTGATGTCCTGAAAGGCCCAGTG
GATCAGTGGAATGAAGCGGGCAGGAAGACTTAGTGCTCCTGAAACAAGGAATCCAGAATCCAGGAGAAGG
ATGGCTCAGTGGGGCTTTCAAGGGACAAGTATGGGGGTTGAAGGGGTCACTGTCCCTATACCAAATCCGA
AAATATTGTGACCAGGAACCATTCTGTCCAACTCTTCTATTTCAGGTGGCAAAGCAAAGCTATATTCAAG
ACCACATGCAAAGCTACTCCCTGAGCAAAGAGTCACAGATAAAACGGGGGCACCAGTAGAATGGCCAGGA
CAAACGCAGTGCAGCACAGAGACTCAGACCCTGGCAGCCATGCCTGCGCAGGCAGTGATGAGAGTGACAT
GTACTGTTGTGGACATGCACAAAAGTGAGGTGAGTCGCAGGACAGAAGAGTGCTTTTTGTTTCAGCAGAG
CAGCCTGGGGAGAGATAAAAGCTACTCCTGGGGCCTGGGCCTGCATTCCTGAGATGTGGGTAAGAGGGGC
CCAGGGTCAGAGTGTCTGGCAAGCTTGGCTCTGCCCCTTTGCTGTCCTGGAGACTAGGGCTAATCCTGGG
CTCAGGGAGTGGCCTCCCCATGGTTAGGATACAAGTGCTCATCAAGGGCCACCCCTAGGAAGGACCAATT
TTCCTATCAGAAGCTTCTAAGTTATCCTCCTTTGGCCCAAAGGGACACCTCAAGCCTACTCTGAGGAACT
CTTTCCAATGAACTAATTCCTACAGTCACTTCCCCAGCAACCTGTGCCTCAGCCTCAAGGCACTGTGGGG
TAGGCCTCAGTTTGTGGCCTGGACATCGGACTGTGGACCAGACGACTCCTCCCGATTTCTGTTTGTTTTC
AGTCCTCTGACCCCAAGCTGGCTGGTGAAGTAGGTAGAGGGAGGAGACTTTGGTGCATGCATACACACAC
ACACACACACACACACACACACACACACACACACACACACACACACGTCTCCTGTGCCCCCCAGTCTCCA
TGGCTGGTCAATGATTGACTGGCATTTCACAGGCCGCTGGTTGCAGCCCCAGCCTGTTGACTTAGAGGTC
ACCCTCGGAAGCTAGAGCCCTGTCCTGCCTCTTCAGTGTCAGTGGTCACTCCACTGCCCACAGGCTGGGG
TCTTGGGCAAAACACACGCATCTGCCCTGATCTGAGTTTGCTGCCCTCTGTCCCGCAGTCAGCCCCACTC
TGTTCCCACTCCCTCTCCCCAGCCCCCTAGCTAGACCCCTCTCACCAGCACCCCTTTCCCTTCCCTGAGG
GTCCCCCTCGCTGTCTTTGTCCCTCAGACATCCTCTTTCCTGGGCTCTCCTGCCAGGCCCTGCTGGAGGG
ACAGTTAAGGAGGAAATCGAATCAGCAGCGCCCACCCCTGCCCCCCTTCCTCTCCTCTTGTCAGACACCA
GACGAGGTTTTTTCCTCTGGCTTCCCAGCTCTGAATGGGCTCATTCTTTTTCAGAGGCTCGGCCCCTCTC
GAGCCTCCTCCCCAGGGCGTGAGTTCTGACCCCAGCTCCTCCCCCCATCCCCACTCCAGCCCCCTCTCCA
GCTTGCTCCACCCTCTCTACCGCCCACCGGGACTGGGCATTGTCTGCCAGTCCGGGTTTCTTCCTGGGAT
TTGGGATGCAGAGAGGATGGGTTTGCTTGGGCGGGGGGGTGGAGAGTGAAGGGGGGAAGCAGGATCTTTG
TAGAGGGAGGGACCTACAGTTACCTGGACTTCTTTCCTCTGTCTCCCCTCTTGGTACCCTTGACTGGGGC
TCTTGAGGGTAATGGGTGAAGCCAAATCTGCCATGGCTCAGTTCCCAGCTCAGCTCTGTGACCTTGGGAA
AGTTCCTTTAGCTCGTGGAATCTCAAGGCTCAAGGTTCCTCTTCTGCAAAATGGGGAATGATAACACCTG
CCTCCTCTGGAGTCTTGGGGACTCAGTGTTCTGAGGAACGTGGCTGTAGGTCAGAGTGGCACAGAGTAGG
GTCCAATGAAGCATGGCGTCCACAGTAGCTTTCCTGACTGGACTAACCTTTCCGGACACAACAGCAGGGC
AGGGGTGGGGCCTGGGGAGAAAGGACACCTCTAACCCTGATCCTAACATCCCGATGGCCTCTAAGGCTGC
CTGCACACTCATCCAGGTGCAAGCCCTCCAAGGTGTGGTGTGATGAACCAGTGACTCCTGGAGCCAGGTC
AGCGCATCCTCTTCCCGCAGGGCTGTAAGCTGCAGGACTGAGAGGCAGGTTGACCAGGTCCTGGGCTGGA
TGATGGGGTGAGAGTAAGGGGTCAGTTTTGATACATGCCCAACTTTTCTCTCTAGCCCTAAGACATCCTG
GGCAAATTGCTTACCTCAGTTCCCCTGATCCTCACCCTAACCCTAACACCAGCTCAAGAGAAAATAGGGA
TATTGATGGCCATCCAGAAGGGCTGCTGTGTTCCATACACAGCAATATTTCTCGAATGTTTGTGACAGCG
GTCCAAGGAATAAGTTAATTTTACATTATCACTCTGGATACCTGTACAAAACTCCACCTTATCCTTACTA
TATGAATGTGCTAGGGTTGTTTTTTTGTTTTGTTTTTTTTTTTTTTTTTTGAGACAGAGTTTCGCTCTTG
TTGCCCAGGCTGGAGTACAATGGCGCGATCTTGGCTCACCGCAACCTCCGCTTCCCAGGTTCAAGCGATT
CACCTGCCTCAGCCTTCCCGAGTAGCTGGGATTACAGGCATGCGCCACCATGCCCGGCTAATTTTGTGTT
TTTAGTAGAGACAGGGTTTCTCCATGTTGGTCAGGCTGGTACCAAACTCCCGACCTCAGGTGATCCACCT
GCCTTGGCCTCCCAAAGTGCTGCAATTACAGGCATGAGCCACCGCACCCAGCCGTGCTAGGGTCTTTTTC
TGTTCAATTCCTTTCTCTCTCTTGCTCTCTTTCTTTCTTTCAATGGAGTCTTACTCTGTCACCCAGGCTG
GAGTGCAGTGGCAAGATCTCAGCTCACTGCAACCTCTGCCCTCTGAGTTCAAGCAATTCTCCTGCCTCAG
CCTCCCGAGTAGCTGGGATTACAGGTGCCTGCCACCACACCTAGTTAATTTTTGTACTTTTAGTAGAGAT
GGGGTTTTGTCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCGTGATCTGCCTGTCTTGGCCTCCCA
AAGTGCTGGGATTACAGGCATGAGCCGCCATACTCGGCCAACTTTGTATTACTTTCTTAAAGAGAGTTTC
CCAAATTATATAAGCTTCAGGCCCCACAAAACCTAGATCTGCCCCAGTATAACTAAATCTGGGACCATTT
ATTGAGCAATTATTATGTGCCAAGTATTGCGCTGAGTGCTTCCAGAGCATTATCTCCTTTAACCCCAGCA
TAGTATGTCAGATGCTGTTTTACAGATGAGCCAACTGAGACCAGAGATGCTCAGTCACTTGCCCAAGGTG
ACATGACTGATATGGAATAGAGTCAAGATTTTTTTTTTTTTTTTTGACACGGAGTCTCACTCTGTCTCCC
AGGCTGGAGTGCAGAGGCGCAATCTCAGCTCACTGCAAGCTCTGCCTCCCAGGTTCACGCCATTCTCCTG
CCTCAGCCTCCTGAGTAGCTGGGACTACAGGCACCCGCCACCACACCTGGCTAATTTTTTGTATTTTTAG
CAGAGACAGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCTGCCTGCCTCGG
CCTCCCAAAGTGCTGGAATTACAGGTGTGAGCCACCGCGACTGGCCAGATTCAAGATTTGAACCCAGGTC
CTCTTGGTCCCAGAGGCCCCTGTTTCTCAACTCCCTAGGATGGCATAGCAACCTGTCCCACAAGAGGTGC
CTGCTTTAAGTGTGCTCAGCACATGGAAGCAAGTTTAGAAATGCAAGTGTATACCTGTAAAGAGGTGTGG
GAGATGGGGGGGAGGGAAGAGAGAAAGAGATGCTGGTGTCCTTCATTCTCCAGTCCCTGATAGGTGCCTT
TGATCCCTTCTTGACCAGTATAGCTGCATTCTTGGCTGGGGCATTCCAACTAGAACTGCCAAATTTAGCA
CATAAAAATAAGGAGGCCCAGTTAAATTTGAATTTCAGATAAACAATGAATAATTTGTTAGTATAAATAT
GTCCCATGCAATATCTTGTTGAAATTAAAAAAAAAAAAAAAAGTCTTCCTTCCATCCCCACCCCTACCAC
TAGGCCTAAGGAATAGGGTCAGGGGCTCCAAATAGAATGTGGTTGAGAAGTGGAATTAAGCAGGCTAATA
GAAGGCAAGGGGCAAAGAAGAAACCTTGAATGCATTGGGTGCTGGGTGCCTCCTTAAATAAGCAAGAAGG
GTGCATTTTGAAGAATTGAGATAGAAGTCTTTTTGGGCTGGGTGCAGTTGCTCGTGGTTGTAATTCCAGC
ACTTTGGGAGGCTGAGGCGGGAGGATCACCTGAGGTTGGGAGTTCAAGACCAGCCTCACCAACGTGGAGA
AACCCTGTCTTTACTAAAAATACAAAAAATTAGCTGGTCATGGTGGCACATGCCTGTAATCCCAGCTGCT
CGGGAGGCTGAGGCAGGAGAATCACTTGAACCAGGGAGGCAGAGGTTGTGGTGAGCAGAGATCGCGCCAT
TGCTCTCCAGCCTGGGCAACAAGAGCAAAAGTTCGTTTAAAAAAAAAAAAAAGTCCTTTCGATGTGACTG
TCTCCTCCCAAATTTGTAGACCCTCTTAAGATCATGCTTTTCAGATACTTCAAAGATTCCAGAAGATATG
CCCCGGGGGTCCTGGAAGCCACAAGGTAAACACAACACATCCCCCTCCTTGACTATCAATTTTACTAGAG
GATGTGGTGGGAAAACCATTATTTGATATTAAAACAAATAGGCTTGGGATGGAGTAGGATGCAAGCTCCC
CAGGAAAGTTTAAGATAAAACCTGAGACTTAAAAGGGTGTTAAGAGTGGCAGCCTAGGGAATTTATCCCG
GACTCCGGGGGAGGGGGCAGAGTCACCAGCCTCTGCATTTAGGGATTCTCCGAGGAAAAGTGTGAGAACG
GCTGCAGGCAACCCAGGCGTCCCGGCGCTAGGAGGGACGCACCCAGGCCTGCGCGAAGAGAGGGAGAAAG
TGAAGCTGGGAGTTGCCACTCCCAGACTTGTTGGAATGCAGTTGGAGGGGGCGAGCTGGGAGCGCGCTTG
CTCCCAATCACAGGAGAAGGAGGAGGTGGAGGAGGAGGGCTGCTTGAGGAAGTATAAGAATGAAGTTGTG
AAGCTGAGATTCCCCTCCATTGGGACCGGAGAAACCAGGGGAGCCCCCCGGGCAGCCGCGCGCCCCTTCC
CACGGGGCCCTTTACTGCGCCGCGCGCCCGGCCCCCACCCCTCGCAGCACCCCGCGCCCCGCGCCCTCCC
AGCCGGGTCCAGCCGGAGCCATGGGGCCGGAGCCGCAGTGAGCACCATGGAGCTGGCGGCCTTGTGCCGC
TGGGGGCTCCTCCTCGCCCTCTTGCCCCCCGGAGCCGCGAGCACCCAAGGTGGGTCTGGTGTGGGGAGGG
GACGGAGCAGCGGCGGGACCCTGCCCTGTGGATGCCCCGCCGAGGTCCCGCGGCCGGCGGGGCCAGAGGG
GCCCGGACGAGCTCTCCTATCCCGAAGTTGTGGACAGTCGAGACGCTCAGGGCAGCCGGGCCCTGGGGCC
CTCGGGCGGGAGGGGGCAGTTACACGGCAGCGGCTCGAGATGGCCCATCCAAGAGACTGGCGCTTTCCAG
GCTCCGAGGGGCTCCGGGAACTTGTCAAAGAAGTTCTCTGAAATTGTTCAGAAAGTTTTCCCGCAAAGGG
TGTATTGCGTAGAGCGCGCGCGCGCGTTTCCCCCCTTCTTGAGCCCCCTCAAGCTTTCTCAAAGCCTTTC
CAGTTGGCAGCCTCCGCCTCCGGACTGGCCTGGGCTGGATTCCTTGGGGGGGTCCTCTGCCCTGCCCCTC
CTCCAGCCCCTCCCCGCTCCCCTTCAGACGATTTTGGTTTGGTTGCTCCTGCTTCTGGCGGGGTCGGGTG
TGTGTGTGTGTGGTGGAGTGGAGGGTGGCATAGCAACCTGTCCCAACCAGAGCCGGGGAGGAAAGGGTGG
CCCGGAGGGTGGCCTCTTGCTGGGGTCTGGGTTGGGGGCGGGGGAGACGTTTGCTTTGAACAGATTCTTG
GGGCCAGCTTAGGGACTGTGCTCTGTGACTTTTGGAGCGCGTGGACCATGGAGGGGTGGGGGTGGGTTTC
TTGGGGTGTAAAGTGGGAGAGTTCCCAGAGAAGGAAGCTAAGAAATAAGGCCAGATGGGAGCCTAGGGAG
GGCTGCGTTGTTCTGCTGCCTTTTCCTTGGTGCTGTGCGTGGGGAAGGGTGAGTGGGGGCAGTGTGTATC
CTGACCCATCTGTCCACCTGTGTGCATTAATCATAAAAGCTAACATATAGCCTGGGCCAGGTATACTCTG
CCAGGAACTGTTTGTGGTGTTTTGCATGCATTCTCCTTTAATCCTAGAACACCCCTATAGTGGAAGTTCT
GCCAGCATTCTGGACTGAGTAGCAGTCCAGAGGTTGAGTAGCAGCTAGTAAGTGGTGGGGTCAAGATGGG
ACCCCAGGCAGTGCGACCCCCAACCATGCATTCGAAATCGCTATATGGATGAGTGCACCTGGAGCAATGA
GGGACACTGCTCCCTGAGTCACTGGGCTGCAGGGGAGACAAAATGAAAGTGTTCTGGGAGTCGTGGGTGG
TCTCCATAGGTCAGAGGGTCTGGGGAGGGAGTGGGTGTCATCGTGGCTGTGTGTTGCCCGAGGGGCCCTC
TGTGAGTGAGTGCATGGCCGTGTTATCTCTGCAGGTCTACGCCAGGGTGTTCCTCAGTTGTGTGGTCTTT
GTATTTGTGTGTCTGGGCTTTGTGTTGCCAAACAGCAGTCTCTCTGCTGACTTGGGGACACAGGCTGAAC
TCTGTCCTCTGCAGGAACTCCCTTAAGGTGCTGGGCCAGATCTGCCATAAACAGAGGGAGGTAGCCTTCT
ATGGCCACGCCTTCTTGCTGAGGAAGAAGGTTCCTCTCTTCCAGGGAGTACATCCTTGCCCTCCCTGTTT
CCCAGACAAGCATCTTCACCTCTCATCTTCTGATGAGAAGGGTGAGGCCATACTGAGCTGTCAGGCTGAG
CTGCTGCCCTTCCTCACCTTGGGCTGGGAGTTGATCAGGGAATGGCAGTTGCTGCAGAGCTGGATTTGAG
GGCTGGGTTCTCTGGATGGGGCCTCCTCATGTCCTCACCCCTCAACCTGCACTATTGATTGTGTTGTGCA
GGAGTTAGTTAAAAAGTCATTGCACAGCCTGGGCAACAAGGCAAAACTCTGTACAAAAAATACAAAAATT
AGTTGGATGTGATTACACGTGCCTGTAGTCCCAGCTACTCCGGAGGCTGAGGCAGGAGGATCACCTGAGC
CCAGGAAGTTGAGGCTTGCAGTGAGCTGTGATTGCAAATGCTCTCCAGCCTGGGTGACAGTGTGAGACTC
CGTTTCAGAAAAAAAGTATACCACCCAGCTGCCTCCAGCACCCAGATTTTACCCAAGGGGTGAGGTCTGG
GGCAGGAATGTGGGGGAAGGGGAGGCCTAGGGGGAGCCCCAGAGGGGTCAGGATTTTTCTGAAATCCTTT
CTTAGAGGTATGGGTTTTACAAATTGCAGCAAATACATCCTTTTAATCTTGCAGAACTCCTTCATATTTT
AATTCCAGTATGATTCTTCCAACAGCCTCCTCTCTTTACTATACTTGGGGAAAGTACTCATTTTATTTGT
CAAGAAAAAAACAATTGAAAAGATAGGGATCAAATGTAAAAAGAAAAAATACGTGGCATTCCAAAGTCAA
ACACAAAGCATGTTTAATTTTCTCGTGGTTTGGGATTACCCATATTCCTGCTGTATGAACCTGTCTTGTC
TTAACTTTTAAGAAATGTACGGTGTACTTCCTATATGCTAGGTTTTTATCCATGCTTTCATTTAATCTCT
GTGACAGTCCTGTGAAGTAGGTGCACAGATGAGAAAATGGAAGTTCAGAGAAATGAAGCAACTTATCCAA
GGCTCCCAGCTACCCAGTAATGTCCAGGGAATTTTTGGACTCTGAAGAGGAGGCATTAAGAGGTGGTTAG
AGTCTTATTCCAGCCAACAATAATGGGTTGAACAAAGCCTTAGGGGCAGGCAGGTGGCCAGATGGGAGGA
GAAGCGCTCCTCTTGTTCAGGCGAATGACCTTTCCATCCACTTCTCTAGGCTGTAGAAAGTGGAGCTGAG
CTGGGGGCCCTGAGGTTCCCTCTTGACTTCAGAGTCCTCTCCCTTCCTGTCCAGCCAATGCCTGTCTTCC
TTTTGGGCCCTACCAGCATGACAGGGGGCTGCGGGCAGGAGGGGACAGAGGCCACGTTGACACACAGGGC
TGTGGGTGAGAGAGACAGCTGAAGTGTCAGCGTGAGGGGCCAGTGTGGGGCTGCGGCTGGGAGGGCTGGG
GTGGGGCCCAGGGTAGTTGTGCCTGTCCTTGGGTGATGGAATGATCTGGAAAGAGATTCCTTCCCTGCCC
TCCACCTGTGAGAAGCCCCTCTAGAGTGACATCTCCATCTTATGTTTGGCCACCCATCCTCCCCCTGGGA
AGAGAGCCGAGGTGGGGTAAGGGATGTGTACTCTTTCAAGGAGTGGGAGAATTATTCTAGCGAATGTTTG
TGTTGTCCCAGTTCTGTTTACAAAGCCTCGTCATGTTTACAGATGGCTGCGCAATTCATTACCTCATTTA
ACTCTCATGTACCTCCTCTGAGGGAGTAAGAGCTGTTACAGCCAAGTTTAGGTCAGTAAATATTCACCAA
GTTGCAGGTACTGCAGGGCATAGAGATGAATCCGATTTAGCTTCTGCCCTGGAGGTCTGGGAACTTGCTC
AAGATCACTCAGTGAGCAGCTGAGCTAGGGTTCTCAACTAAAGACCCTGGGCCCAGGCCCTGGTCTGATG
TCAGGCCTGATACACCAGGTGTTTGTGGTCGGGGAATCCCAGTGTCACTTGAATGGGCTGTGACATTATG
GGTCTGGGAGAGCTGAGCTTTGGGGACACAGGTCATTTTACTGTAGTATTCATGGAAACCAAGGGAAGTA
TTGGCTTTTCTGCTGTGAGCAAGAGGAGCAGCTGGGGCTGCAAGCTGGTGGGGAGGAGAGAACCCACCTG
AGAGAAACCTCAGGACTGGGGTCAAGTCCTGACCACCAGAGTCCAGAGAGACATGAAGGACTGTGACCAG
CTCTGAGCAGAGAGATGGATTCCATGACCTCAACTGGTCCCTTTTGTTCGGAGACTCGTGACTGGACTTC
ATTCATCCACTCATTCATTCATTCACTCAGCAGACACTTATCTAGCGCTCCCTGTGGCTGGTCCTGCCTC
ATACTGTCTTTGCTCTGGAGAATTGGAGGTTGGGGTTCCTGAGGGGCAGGGTCCTGGAGACAAGGACACT
CCTGGGTAGAATTAGGACCTACCCCCCAGGAAATCAACGGGGACCAGGTGCCGTGGCTCACACCTGTAAT
CCCAGCACTTTGGGAGGCCGAGACGGGCGGATCACAAGGTCAGCAGTTCAGGACCAGCCTGGCCAACATG
GTGAAACCCGCCTCAACTAAAAATACAAAAATTAGCCAGGTGTGGTGTCAGGCACCCGTAATCCCAGCTA
CTGAGGAGGCTGAGGCAGGAGAATTGCTTGAACCCGGGAGGCAGAGGTTGCAGTGAGCCGAGATTGCGCC
ACTGCACTCCAGCCTGGCGACAGGGCGAGACTCCATCTCAAAAAAAGAAAACCAATGGGACAGGGCAGAT
ATGGGGACAATGGTAAGGAGATGGGAGAGTGGGAGGGAGGTGTCAGGAAGACCTTCTTGACTTCATGTAG
GCTGGTGGGGGTGTTAGCCAGCAAGCCTCCAGTTCCCTGGGAACCGTTCTCAGGGTACCAATTTTACCAC
CTGTCTGCAAACACTTTAAGATTCTTAATCAGACTCAAATTGGCCACAAATCAGGTAAACAAACTCACTA
GTGGGGTGGGGCTACCACCCGTTCTGACCCTCCAGCCCAACCCAGCCCAGCCACCCTGCCCTCCGTAGAG
CCTGTGGTGTTTATCGGTGGCATTGGGAGAATTAGTGTGTATTTATGTTGGCGTGGGGTGTGGGGTGGAT
TTGTGTGTGTGCAGTTAGGCCTAGTGGAAGGAATGTGGGATCTGAAGGCAGGCCAGCCTGAGTTCCAGTC
CTGCCTGTTGCTCACAAGCTTTATGAGGCGAGAGCTAACCCCTGCCAGCCTCAGTTGTCTTCTTTGCAAG
ATGGAGGTTGCAGCCCCAGTCTCTGGAGCATGTTATGCAGATCCACCGAGAGTGCCTGCCAGGCACACAG
TAGGTGCTCAGCTCAGTTACTGTGGCGGCCCCCACTCCCCATTGTTGTTGTTTTCCTATTGCCTGGCGGC
CACAGCTGGTATCCCTTGAAAAGGGCTACAGGGGGTGGAGTCGGACCCTGCCCCAGCCCTGTGGAGACCC
TGGGCTTGGGCCAGGGCCTGGGGTCTGGGCCTGCAGACAGCTGTGTCTATAAAGCAGCTGAAGGGCTGAG
GCCGGGGGAGGTCCTGGCAGCAGGGCGTTATTTTGGGCCTGGCCTGCCACCCCCAGCTCCTGTTTCTCTT
GGGAGTCTGTTGGGGGAGGAAGTGTGGGGAAGAGGAGGGGGTGCAAGTGGGTGAGGCATGGAGTGGGGAG
GCCTCCCTCAGGGACATGGACCCTTGAGTTCTATTTCTGTTCCTCCCTCCTGTTCCTCCCTCTTTGTCCT
TATCTGCCTAGAGAGGTGGGAATAGAGGCCATTCTGAGTATCACTAGGAGACCACCAGTTTGTGGCCACT
GGCCACTGGCCCAGGCAGGGAACCTGGGGGCTTGCCCTACCAGCCTCTCCCAGCAATCTGAAGGCAGGGG
GTACCTCGTATTACCCCCTAGGATTTGACCTTAGGCTCCAACTTGCTGGGAGAGCAGTGCCTCTGGTGTC
AGACCCCAAGCCAGCCCTTGTGCTGTCCCTGAATCTGCATGTAGCCTGTGGGAGGCGGAGCAGTGACCGG
CAGGAATTCTGGGCAGCTCAGGCACCTGTGGGCCTGAGGGTGCCCTCTGCCCCCACCCTTCCGATCTCCT
GGGCAAGACACGCCAGGTGATTCATCTCACCAGAGCAGAAAAACAAGTTCAACTGGGCACTTTAATCTCC
CCTCACTGGCAGGCCTGGTGTGAGCTGCTACCCCGGCGCCCCTCACCAGGGGTGCTTTACCTCCTCTAGT
ATTCCTGACCTTAGTGGGCATTTCTGGTCTCAGGGATACCAGGCTGGGGTCCAAGTGGGCCAGGTGTGGC
AGTTCAGCCCTATGCCCCATGGCTGATGGCTCGCGCTGGGCAGGTATGCAGGGCTGACGTAGTGCCTTTG
TGGCAGCAGTTTCGTGGCACACATTCTGCCAGCTGGTTCTGGAGTCTTGCCCTGAGGAGGTGGCCAGGGT
GAGGGTGCCAGCGCAGGAACCTTTGGCGCATGCTTCACCCTGGCCTGGGATCTGCAGCCTGGGTCCAGAT
GCCCACAACTGGAATCTGACGCTCCTTTTCTCTTCATGGGGGACTCCCAGAGGTCTCTGCAATGACCAGA
GCCCCGGTTGTCCCATGCCTCAGCTGCAACTCCAGCTGACCCTCCTTCCCCACTCTCTGGGTGGCATTAC
GGGGGTGTGGATCCCTTGCCAAGAGGTTGGCATGTGGGTGTGCTGGAATGGCATAGGGAGAATGCACCGA
GTTTGTTTGCTTGGGAGAGGGGCAGGGGGTATCCAGAAGATTCATGATTCGTCATCGCCTCTCTTGGGGG
ATTTTTACCCCTTTGCCCTGAGTTGTGCCTTTGGGACAAAGGAAGCCTTTCTTTGCCAGCCAACACCCTG
TACTGGCGGGCGAGCTCCCCAGGGCTGGCACGCTGGGGCAGCCTCTGAATGCACAGGGTGGGCCTAGTCA
GAAGAAGCCTTTCCCCTGAAATCCCTCTACTTCCCAAGCACGCAAGCTTTCTCCTGCTGTTAAACCTGCA
GTGTGCAAGGGACATGGGCGGAGGGGTCCTTCAGTCAGGCTTCTCCCTGTCTGAGGTGGCATGACTTGGA
GTGAGTTTGGATGGGGTGGCCAGGTCTGAGAAGGTCCCCCGCCAGTGTCCTCTGACCCATCTGCTCTCTC
CTGCCAGTGTGCACCGGCACAGACATGAAGCTGCGGCTCCCTGCCAGTCCCGAGACCCACCTGGACATGC
TCCGCCACCTCTACCAGGGCTGCCAGGTGGTGCAGGGAAACCTGGAACTCACCTACCTGCCCACCAATGC
CAGCCTGTCCTTCCTGCAGGTGAGGCCCGTGGGCAACCCAGCCAGGCCCTGCCTCCAGCTGGGCTGAGCC
CTCTGTTTACAGGTGGGTGGCAGAAGAAGGTGCCCTGCCCTTCTGTTTCCTCTCTTGTTGTGGTTTCTCA
ACCAGGAAGTCCTTTCTAACATCTAACCCCCATTCATTTTACTGCAGAATCAGTTGACTCTCTCTATAAC
GTGGCTGGCCGAGGTCATGTCTGGATGGGATGCGTCTGTGTTTCCGCTAAATCTTGTGCTCTCTTGCCAG
CATGATCATGTCCCCTGTCCACCTGCTCCAGCCACTATCCCTCTCCCACTTACAGCAGAAGAAAGGGCTG
GTGAGAAAGGTGGATTACAGGCCCACTTCTGCCACTGACGAGCCCTATGAATGTGGCCTACACCCCCTTA
GCTTCACTGGGTCTCAGTTTCCCTATCTGTATATTGGGAGCAGTTGTGAAGCTCAGAAGAGAAATGTCTG
TGAAAAGGTTATGAACAGGAGGGAGAGTGGAAACCAACCTGCTGGATCGTGTCCACAGACCCTGGAATGG
GGCCACATGCTTGGTTTGTCAAATTGCAGACGCCGGCCGGGTGCGATGGCTCATGCCTGTAATCCCAGCA
CTTTGGGAGGCCGAGGCGGACAGATCACTTGAGGTCGGGAGTTCGAGACCAGCCTGACCAACATGGAGAA
ACCCCGTCTCTACTGAAAATACAAAATTAGCCAGGCATGGTGGCACATGCCTATAATCCCAGCTACTTGG
GAAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGACGGAGGTTGTGGTGAGCCTAGATCGTGCCATTG
TACTCCAGCCTGGGCAACAAGAGTGAAACTCCGTCTCAAAAAAAAAAAATTTGCAGACGCCATCCCATCC
AGGCCTTTGCTTTCACTGATGAAGAAACTGAGATACAGAGAGGGCAGGGCACCTGTTCGGAGTTTATGAA
ATGCCCCCCCACCATTATCTTTCTTGATCATATAAGAATCTGGTGAGGCAAGGTAGGGCGTGATCTTTAT
CTCTATTTTATCGTTTTATTTAAGCGGGAACAGGACTGCTCAGTGGCTGGGGGCCTTGCCCAAGATCTCC
AAGTACTGGGGAACCCCAGGGAGGCCCTGGGGGGTGGCAGTGTTCCTATTTCAGCCCCACTCTGCTTCCC
CCTCCCAGGATATCCAGGAGGTGCAGGGCTACGTGCTCATCGCTCACAACCAAGTGAGGCAGGTCCCACT
GCAGAGGCTGCGGATTGTGCGAGGCACCCAGCTCTTTGAGGACAACTATGCCCTGGCCGTGCTAGACAAT
GGAGACCCGCTGAACAATACCACCCCTGTCACAGGGGCCTCCCCAGGAGGCCTGCGGGAGCTGCAGCTTC
GAAGCCTCACAGGTGGCCTTCACCGTCATTGAAACCTTCTCTTGGTTATTCAGAGCTGACCAGGGCCACT
GCTAACCAGGGGGAGGCTTTGTGTGCATTAGAAATGGTGTCCCTTCTGGGCAGACGCAGGCAGAGCCCGG
GAAGACGCCCTCAGAAGATTGGAAAAAGATTCCCCTTCTTCCTGGGAAGTTGTAGCTTGCGTCAGCACAT
ATAATTCAATCGTGAGAATGCAGGCTGGGTTTTTGCCCCCACTTGGCTGAGTGAAGTGTACAGTGAACAA
CCTATGTAACTATTTGCTGGCCCTGGAGCCGACTCTGCCCCAGAGTCTGGGTGCCAGGTGCTTTGCCCGC
ATGGCCCATTTCAGTCACGCTGCAGTCCTGTCAGGAAAAAATCAGTGTTATTCTCATTCTACATATGAGA
AAACTGAGGCTTGCAGATATAAGGGCCAAAAGTTACACAGCTAGTGAGTGATGGGGCTGAGTTTCAGACT
CCACAGTCTCTTAACCACCAAGCAGCATGCCCAGAGTAGAGGTGAGAAGGAAGGAGAGAGCTGCGGTCCA
CATGAGCATCTGGACCTAGCATGGACAACTCACTCCTCCCTGGCTCTCGCTTTGTTCTTGTTGCGGGTGT
GGTGGTGGTGGGACTCAAAGACGGTAAAGATAGCTTTCTCTCCTCCCTGGGGAATCTGGGGGTTGTTTAA
AAGGCCTGCTCCTCTTTTAGAAGGCAGGAGGGCCCCAAGGGAAGCAGAAGGTGACAGAAGGGGAAAGGGT
CCTCTGATCATTGCTCACCCCACAGAGATCTTGAAAGGAGGGGTCTTGATCCAGCGGAACCCCCAGCTCT
GCTACCAGGACACGATTTTGTGGAAGGACATCTTCCACAAGAACAACCAGCTGGCTCTCACACTGATAGA
CACCAACCGCTCTCGGGCCTGTAAGCCATGCCCCTCCCTGCTGCCTCTTCTCTCAGACAGCCTGACCCCA
GCCGCAAACTCCCAACTTACAACCCAGTGCCTGCCCGCCACTGCCCCAGCCGCCTACACCACCCATTTCC
TCCCTCTCTGTCCCTCCTGCCATCTCCCTGTGCCTCTTCATCTCTGGGGTTCTCTGTCTTGTCTCCCTCT
GCTTATAGGTTGTGCCTCTGGTTTGGGGGCCTCTCAGCCTGTCTGGGTCCCTCCCTTGCTGTGCAGTTGG
CCTCGTGGCCTCTGCTGCTGTTTGTGCCTCTCTCTGTTACTAACCCGTCCTCTCGCTGTTAGACATCTCT
CTCACTGCCTGTCTCTGGTTCTGTCCTCAGGCCACCCCTGTTCTCCGATGTGTAAGGGCTCCCGCTGCTG
GGGAGAGAGTTCTGAGGATTGTCAGAGCCGTGAGTCTCAGGGAGGCCTGGAGTCAGGGAAGGGGAGGGCT
GGGGCCGGGTGGAATGCAGGTGTCATACAGGTGACATGGGAGGGGTGGGATAACAGGCTTGGGATGTCTC
CCCTGGGCCAGGTAGTCTCCCTAGAAGGTGATGCTGATGAGGGTCTGGTGCCCAGGGCGCCACTCAGCCC
TCATCCTGCCCTTTGCCCAACAGTGACGCGCACTGTCTGTGCCGGTGGCTGTGCCCGCTGCAAGGGGCCA
CTGCCCACTGACTGCTGCCATGAGCAGTGTGCTGCCGGCTGCACGGGCCCCAAGCACTCTGACTGCCTGG
TATGTGCCTCTGCTTTGTGCCCAATGTGCTCTACCCCCCAGGATGCAAGGGGTGGGCACCCTGCCTGGTA
CTGCCCTATTGCCCCTGGCACACCAGGGCAAAACAGCACAGTGAAAGCCAGCCACCTGTCCCCCCAGGCC
TGCCTCCACTTCAACCACAGTGGCATCTGTGAGCTGCACTGCCCAGCCCTGGTCACCTACAACACAGACA
CGTTTGAGTCCATGCCCAATCCCGAGGGCCGGTATACATTCGGCGCCAGCTGTGTGACTGCCTGTCCCTG
TGAGTGCCAGGGAGAAACACAGTTTTCTCATTTTGGTGGGGAGGTTTGTTTCTGTAAATGGGAGCATATG
GGGAGCACTGTCTGCATCTTGCTTTGAGAGCTGGTCATGACAGTTCCTGCCGAGCTGCCTTGTTCTTTCA
ACAGCTGTGGAGCAGGTGGCAGTAAGGAGAGGCAGCTAAGAGCCCAGACTTGGGAGCCAGACTGCCTGGG
TTTGAAACCCAGCTCTATCAATTAGTAGGCACGTGACCCTCTTGCTGTGCCTCAGTTTCCTCATCAGTAA
AATGGGGGCAAGAATAGTCCCAACTGCATAAGATGGTTATAACATTTGAAAGAGTTAATATTTGTAAAGC
TCTTAGAACGGTGCCTGGTATGTACTAAGTGCTCCTAAATGTTAGCTTTTATTCTATAGCCTGGTGAGGT
CAGTTTTACCTTTCGTTTTGTTTTTGAGACCGAATTTAGTTAGCTCTATCGCAGTGGCGCGATCTCGGCT
CACTGCAACCTCCGCCTCCCAGGTTCGTGCTATTCTCGTGTCTCAGCCTCCTGAGTAGCTGGGATTACAG
GCGCCCACCACCATGCCTCGCTAAATTTTGTATTTTTAGTAGAGACAGGGTTTCACCACGTTGGCCAGAC
TGGTCTCGAACTCCTGACTTCAGGCGATCCACCTGCCTCGGCCTCTGAAAGTGCTGGGATTACAGGCGTG
AGCCACTGCACCCGGACTTTTTTTTTTTTGGCAGAGTCTCGCTCCATTGCCCAGGCTGGAGTGCAGTGGT
GCAATTTTGGCTCACTGCAACCTCTGCCTTCCGCATTCAAGCAATTCTTGTGCCTCAGACTCTTGAGTAG
GTGGAACTACAGGCATGCACCACCATGGCTGGGTAATTTTTGTATTTTTAGTAGAGACGGAGTTTCACTA
TGTTGGCCAAGCTGGTCTCGAACTCCTGACCTCAAGTGATCCACCCGCCTTGGTCTCCCAAAGTGCTGGG
ATTACAGGCATGAGCCATCGTGCCTGGCCTAGCTCAGTTTTATTTAACAGATCACCTATTTACTGATGGG
CGTTTATGGACTGGGCTCAGACCTGGGGAACCTCTTTCCTCCTCTCACAGGAACAGGAGTGGGCCTTCAG
ATCCTGGCTGACTGTGTTAGGGAGAGGACAAAATGTAGAGCCAGACCATTTGGGTTCAAATCCTCGCTCC
TCCACTCACTAGCACAATGACCTTGAATAATTTACAGAACTCTCTGCTTTGGTCTCCCTTTTTGCAAAAT
GGGAATCTCACAGTGCTGATCCCGTCTGGTTGTTGTGAGGGGTAAATGGATGTCAGGTGCTGATGCGTGG
TAGGGCATTTAAGTATTGGTTGATATTATTCTTCTTGTGCCTGGGCACGGTAATGCTGCTCATGGTGGTG
CACGAAGGGCCAGGGTATGTGGCTACATGTTCCTGATCTCCTTAGACAACTACCTTTCTACGGACGTGGG
ATCCTGCACCCTCGTCTGCCCCCTGCACAACCAAGAGGTGACAGCAGAGGATGGAACACAGCGGTGTGAG
AAGTGCAGCAAGCCCTGTGCCCGAGGTACCCACTCACTGCCCCCGAGGCCAGCTGCAGTTCCTGTCCCTC
TGCGCATGCAGCCTGGCCCAGCCCACCCTGTCCTATCCTTCCTCAGACCCTCTTGGGACCTAGTCTCTGC
CTTCTACTCTCTACCCCTGGCCCCCCTCAGCCCTACAAGTGTCCCTATATCCCCTGTCAGTGTGGGGAGG
GGCCCGGACCCTGATGCTCATGTGGCTGTTGACCTGTCCCGGTATGAAGGCTGAGACGGCCCCTTCCCCA
CCCACCCCCACCTCCTCAGTGTGCTATGGTCTGGGCATGGAGCACTTGCGAGAGGTGAGGGCAGTTACCA
GTGCCAATATCCAGGAGTTTGCTGGCTGCAAGAAGATCTTTGGGAGCCTGGCATTTCTGCCGGAGAGCTT
TGATGGGTAAGAGTGGGCACGATGACCTGAGACAGTGTCAGGGCAGACAGAGTCCTGAGGATCCAGATGT
GGCAGCATCTCTTGGGGATGGCAGGAGACAGAAGTGGGGGGATCAAGAATGCAAAGAAAGCAGATGGGAG
ACCAGAGGAGCAGGGCCTTTGGTGGGTGGGGGTGATTATTTTTGTAAATGACATGCTATCCGTGAACAAG
GACTTGTATGGAGGTCAGACCATCTAGATAAAGTAAAATTCCCTTTGAGTTCATAGCAGCTTTATTCAAA
ATATCCCCAAATTGGAAATAACTCAAATGTGCATCACTAGGTGAAGGAATAAACAAGTGGCAGTGTATCC
ATTTGGTGAAGTTCTACTTAGCAACCAAAGGAAATGAACTACCGATACAACATAAATGAATCTCAGAAAC
ATTACATTGAGCAAAAGAAGCCAGAGACAAGATTCCATACTGTCTGATCCCCTTTATGTGAGGCTCTGAA
CCGAAAAAACCACTCTGTGGTGGGAGAGATCAGAACGGTGGTTGCCCCAGGGTGGGGGGCTTCAAAAGGG
AGGCACACAAGGACATTTCTGGGGTAATAGAAATGCTCTGTATAGTGATTGGGGTAGTGGATACATGAGC
GAATCCATTTGTCAAAACTCATCAAACTGTGTGATAAGAGTCTGTGCATTTTATTTATTTCATTTTATTT
TTTGAGATAGAGTCTCACTCTGTCAGCAGGCTGGAGTGCAGTGGTACGATCTTGGCTCACTGCAACCTCT
GCCTCCTGGATTCAAGCAATTCTCCTGCCTCAGTCTCCTGAGTAGCTGGGACTACAGGTGTGTGCCACCA
TGCCCAGCTAATTTTTGTATTTTTAATAGAGATGGGGTTTCACCATGTTGGCAAGGATGGTCTCGATCTC
TTGACGTCGTGATCCGCCCACCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCACACCCGG
TGCATTTTATTGTATATAAGTTATACTTCAATAAGAAATGAATTGGGGCCAGGCACGGTGGCTCACGCCT
GTAATCCCAGCACTTTGGGAGGCCGAGGCAGGCAGATCACTTGAGGTCAGGAGTTCAAGACCAGCCTGGC
CAACATGGTGAAACCCCATCTCTACTAAAAAATATAAAAAATTAGCCAGGCTTCCTGGCATGCGCCTATC
ATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATTGCATGAACTCGGGAGGTGGAGGTTGTAGTGAGCTG
AGATTTCGCTATTGCACTCCAGCCTGGGCGACAGAGTGAGACCCTGTCTCAAAAAGAAAAAAAAAAAAAA
GGGTCAGGCGCCGTGGTGCACACCTGTAATCCCAGCACTTTGGGAGGCTGAAGCAGGAAGATTGCTTGAG
CCCAGGAATTCAAGAACAGCGTGGGCAACATAGTGAGATCCCATCTCTACAAAAAAACACAAAAAATTAG
CCGGGCATGGTGGTACGCACCTGTAGTCTCAGCTACTAGGGAGACTGAGGTGGGAGAATCACCTGAGCCT
GGGAGGTGGAGGTTGCAGTGGGTTGAAATCATGTCACTGTACTCCAGCCTGGGTGACAGAATGAGACCCT
GTCTCAAAAAAAAAAAAAAAAAAAAAATTCCCTTTCACACTTCCTTTACCTCCACTCCCCTTTCCAGAGG
GGGCCATGGTTAACAGTGTGTGTGTTCACCTAGACCGTTTATGCATCTGTAGACACACACACAGTGAAGT
GTGGTTTTCGTCGTTTTGGTGGGGAGGTTGGTTTCTGTAAATGGGAACATATAGGGAGCACTGTCTGCAC
CTTGCTTTGAGAGCCGGTCATGACAGTTCCCATTGAACTGCCTTGTTCTTTCAATAGCTGCAGAGCAGGT
GGCGGCAAGGAGAGGCAGCTAAGAGCCCAGACTTGGGAGCCAGACTGCCTGGGTTTGAAACCCGGCTCTA
CCACTTACTAGGCATGTGACCCTTGTGCTGTGCCTCAGTTTCTTCATCTGTAAAGTGGGGGCAAGAACAG
TCCCAACTTCATAAGATGGTTATACCACCATGCCTGGCCAGATGATTATAAAGTTTGAATGAGTTAATAT
TTGTAAAGCTCTTAGAACAGTGCCTGGCAGATACTAGGTGCTCCTAAATGTTGGTTTTTATTATGTGGCT
GGGTGGCTCGGGGTTTTATTTAACAGCTCCCCTATTTACTAATAGACATTTAGATCATGTTCCATTTTCA
CTCTTACAAACAGTTCCACTTTGTGTGTGGCTCTGGGAACATGGGCCAGTGTCTCCCTAGGCCACATTCC
TAGAAATAAGATTTCTTTTCTTTTTTTTTTTTTTTTGAGACAGAGTCTCGCTTTATCGCCAGGCTGGTGT
GCAGTAGTGTGATCTCGGCTCACTGCAACCTCTGCCTCCCGGGTTCAAGTGATTCTCCTGCCTCAGCCTC
TCGAGTAACTGGGACTATAGGCGCGCGGCACCACACCCAGCTAATTTTTGTATTTGTAGTAGAGATGGGG
TTTCACCATGTTGGCCAGGATGGTCTCCATCTCTTGACTTCGTGATCCGCCCGCCTCGGCCTCCCAAAGT
GCTGGGATTACAGGCGTGAGCCACTGAGCCCAGGCAGAAATAAGATTTCTAGATCAAAGGATATAAATAC
TGTTTTGATAGATGTTGCCGAACTAAGGCCTGGGCTTTGAAGCCCAGGATGGGAACAGCTGGGCTCGATG
GGCAAAGGGTTTGAGTGAAGGCATTCATGGTGGGGAGTGGCTGGCATGGCCAGTGCTGGGAGTGATGTCC
ACCCTGTTCCTGGCCCTGCTGACTCCTCTCCTGACCCCTCCAGGGACCCAGCCTCCAACACTGCCCCGCT
CCAGCCAGAGCAGCTCCAAGTGTTTGAGACTCTGGAAGAGATCACAGGTGGGCTCTGTCTCTGCATCCTG
TTCTGCAGGGGCTGGGAGTCCTTGTCCTGTCCCCACTCCTTTAATCTCACCCTCTGCCTGCAGGTTACCT
ATACATCTCAGCATGGCCGGACAGCCTGCCTGACCTCAGCGTCTTCCAGAACCTGCAAGTAATCCGGGGA
CGAATTCTGCACAAGTGAGCACTGAGAAAGAGGGGGCCTGATGGGGAGGAGTCCCAGGGAGGAGTCCCTG
TGGGAAGCTTTGGGCCTGAGGGAGTACTCCTGTAGCAGTAACCTTTCCATGAAAGTCTGCAGAGTGTGCT
GGGGATGGAGGAAGATGAGAATAGCCTTTGCTGACCGGGAAGGGGTCCGTGGTAAGGTGCCCACCTTTCT
CCCATAGTGGCGCCTACTCGCTGACCCTGCAAGGGCTGGGCATCAGCTGGCTGGGGCTGCGCTCACTGAG
GGAACTGGGCAGTGGACTGGCCCTCATCCACCATAACACCCACCTCTGCTTCGTGCACACGGTGCCCTGG
GACCAGCTCTTTCGGAACCCGCACCAAGCTCTGCTCCACACTGCCAACCGGCCAGAGGACGAGTGTGGTA
AGACAGGGAGCCCAGTGTGCGCACTCCCCATCTGCCAGCACACAGCAGTGCCCAGGGGGCCCTGGCAGCA
GCGTTCTTGGACTTGTGCAGACTGCCCGTCTCTGTGCACCCTTCTTGACTCAGCACAGCTCTGGCTGGCT
TGGCCTCTTGGCATGGCTTCTCTAGCTGGGTCCTACCTGCCTTGGCATCCTTCCCTCCCCCTCTGTTTCT
GAAATCTCAGAACTCTTCCTCTCCCTACATCGGCCCCACCTGTCCCCACCCCTCCAGCCCACAGCCATGC
CCACAGCCAGTTCCCTGGTTCACTTGGACCTGGGGCCTCCCCTAAAAGTCCCCTGCGGTCCCTTCCTCCT
CACTGCAGTGGGCGAGGGCCTGGCCTGCCACCAGCTGTGCGCCCGAGGGCACTGCTGGGGTCCAGGGCCC
ACCCAGTGTGTCAACTGCAGCCAGTTCCTTCGGGGCCAGGAGTGCGTGGAGGAATGCCGAGTACTGCAGG
GGTATGAGGGGCGGAGGAGAGGGTGGCTGGAGGGGTGCATGGGGCTCCTCTCAGACCCCCTCACCACTGT
CCCTTCTCTCAGGCTCCCCAGGGAGTATGTGAATGCCAGGCACTGTTTGCCGTGCCACCCTGAGTGTCAG
CCCCAGAATGGCTCAGTGACCTGTTTTGGACCGGTGAGCTGCTGGCGGGCTCAGAGCTGGGTGGAGGGGG
GCAGCGAGGGGGATTGCCAGGGACTTGGCAGGATGGCGAGATGCAGTAGGGTGTGCTATCTGGTAAAATA
TCCCTGGAGAGGGCTCAGCGCTCAGACCTGAACAGCAACAGAGTGGCAGAAAAGGGGCCTGGGGGACACT
GGGGCCCTTCAGACTATGAAAAGGTTCTAAGGAGGTCTGTGTTGGTGGCTGTGACTGTGGCTGTGCTAGG
GTGGTGAGCCCTGTGGGCTCAGGCGTCAGACTACCTGGATTCAGACCCAGCTCCTGCTTCCAACCTTGGT
TTTTTATTCCTAAAATGGGTATTGTAATAATACCTACCTTGCTGGGGTGTGGCAAGAATGAAATTAAACA
GGGCTTGGCACAGTGAAGCACGGGAAAGGCTTTCTACAGAGCAGTGACTGTTGTTACTCGCTGTTACACC
TTAGGTAATGCGTTTTCCTCTCTGGGTGCCTCCCATTTTCTGGCTCAAGTCCCTGCCCAGGATCAAGCTT
GGAGGAGGGCCCCGAGGGAGGGGCCACAGAGACTGGGTGAAGAGCAAGGGTGTTTGTCCCAGGAGCATGG
CGAAAATTGCTGCTGGGTGGCCTTGGGAAGCACAAAGGGGACCCAACTAAGGGCCTGATCCTACTGCCCT
GGGGGTGTCAGTGCCAGCCCCCCACAAATCTTTTCTGCCCCCCCCAGGAGGCTGACCAGTGTGTGGCCTG
TGCCCACTATAAGGACCCTCCCTTCTGCGTGGCCCGCTGCCCCAGCGGTGTGAAACCTGACCTCTCCTAC
ATGCCCATCTGGAAGTTTCCAGATGAGGAGGGCGCATGCCAGCCTTGCCCCATCAACTGCACCCACTCGT
GAGTCCAACGGTCTTTTCTGCAGAAAGGAGGACTTTCCTTTCAGGGGTCTTTCTGGGGCTCTTACTATAA
AAGGGGACCAACTCTCCCTTTGTCATATCTTGTTTCTGATGACAAAAATAACACATTGTTAAAATTGTAA
AATTAAAACATGAAATATAAATTAATGCCCTAGCAGTTCTATCCCCACTGTTAATAATTTGAAATATTTT
TCCTCTAGTTATTTTTGTCTGTGCACATTCTAATATGTATATATAAGTTAACATATATTAATATTATTCT
CCAGTTATTTTTATCTGTGCACATTTTAACACACACACACACACACACACACACACACATATGTATTTTT
AGACGGAGTTTCACTCTGTCGCCCAGGCTGGAGTGCAGTAGTACAATCTTGGCTCACTGCAGCCTCCACC
TCCTGGGTTTAAGCAATTCTCCTGCTTCCGCCTCCTGAGTAGCTGGGATTACGGGAACGTGCTACCTTGC
CTGGCTAATTTTTGTATTTTTAGTACATAGGATTTCACCATGTTGGCCAGGCTGGTCTCGAACCCCTGAC
CTCAGGTGATCTGCCAGCCTCGGTCCCCCAAAGTGTTGGGATTACAGCGGTGAGCCACCATGCCCAGTCA
TATATTTCTTTTTAACAAATAGAATCATAGATCATACATATTGTTTGCAAATTGCTTTTTCTCACTTTCC
AGAACCTTGAAATGTTTTTCCATGTTCTAACATGGTGATCTACCTTATTCTTTTAATTTTTCTTATTTAG
TTGTCTTTACACATGAAACACATGAATACATCCTTGTGATAAACATTTTCAGTAACATAAAAGTATAAAT
GTTACAAAGCCAACGTGCCCTTTCACTCAACTCCCTGTCCACCCAGTCTCTCCTGTCTGCTGGGAGAACC
ACCGCATTGACTTGTGTGTTCACCCTTCCAGGCTCTTTTCTGCACACTTATATAGACATACTACATTTAT
ATTAGGTCGAGTCAAATAAGATTGCTGTTTGTGTAAACCAAAAAGTGTCAAGAGCCTGGGCGCAGTGACT
CACACCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCAGATCACTTGAGATCAGGAGTTCGAGACCA
ATCTGGCCAACATAGCGAGACCCCGTCTCTACTAAAAATACAAAAACTAGCCAGGTGTGGTGATGCTGTT
CTGCACTTTGCTTTCCCCCCGACTTGAGGTATCCTTTCTTGTGAGTACAGACGGATCTACCACCTTTATT
TTTTTTTTAATTACTCAACCTGTAACATGGATGTAATTTCACTTTGTTTTTGAGGGATATTGAGCTTGTT
TCCCTGTTTTTGCAGTTTATTGCAATTGAGCTCCACACACAAGTGAGCCCTCTTTTGTATGCCCCCTAGT
GGGAATACAGTGCTGGCAATGTTTATCACAAGGATATATTCATGCATTTCAATTTAAAGACAACTAAATG
AGAAAAATTAAAAGAATATGGATCCAGGCTGGGCATGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGA
GGCCGAGGCAGGCAGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGCAAAACCCCGTC
TCTACTAAAAATACAAAAATTAGCCAGGCGTGGTGGTGGGCGCCTGTAATCCCAGCTATTTGAGAGGTTG
AGACAGGAGAATTGCTTGAACCTGGGCAGCGGAGGTTGCAGTGAGACGAGATTGCACCAGTGCACTCCAA
CCTGGGCAACACAGTGCAACTCCTTCTCAAGAAAAAAAAGAAAAAAAAAAAGAATATGGGTCCAGATCCA
TATGGATCCTAGATCCAGATCACGGTGTTAGAACATGGAAAAACATTGCAAGATTCTGCTAAGTGAAAAA
AGCATTTGCAAACAGTATGTACAGTCTATATTCAGAGGAGGAACTGCTGGGTCATAGATGATATTTCATA
GGTATTGCCAAACCGTTCTCTGGAGAAGTGGTATGGGTTTACCCTGGGATTCTTCTATGGAGGGAATAGT
TGAGCTCCCGGGCTTGCTCTTCTGGGTGCCCCTCCCCGCTTCCTATCCACCACAAGGAGCTGCAGGGGAG
CGGGGCATGCCGGTTCCTTGGCTGGAGAAGGAGTCTCCTTGTGAGGTGGTAGAAGGAGCACTGACGGCCT
TGAGCCCAGTTTCTGCCTTTGTCAAATGGGGATAATGACCCAGCCACACCCCTCCCAGGGTTGTTGTGAG
GCTGGAAAGGTGGTTCCCAAGAGGGTGGTTCCCAGAATTGTTGATGAGACTGTTTCTCCTGCAGCTGTGT
GGACCTGGATGACAAGGGCTGCCCCGCCGAGCAGAGAGCCAGGTTGGCCTGGACCCCAGGATGTACCCTT
CATTGCCCTTCACTCCCCCACTGGATGCTGGGTGGTCACTGCTGTAGGGAGGGGACCCCCTGACATATGT
CCCTTCCCACCCACTCTTCCACTGTGGAACCTCCTGTCATTTTCCACTTCACCAAGTGACAGAGGACCTG
CTCAGATGCTGAGGGGAGGGGACTGCAAGGAAAGATGGCTAGGAAACCCAGTCCCTCCACACCCTAGAGT
AACTTGATGCCTTGTGAGGGACACAGGCAAAGTTCAATTCCTTGGAAGTCAAGGGAGACTGAGAAGAGTA
CAGCTGCAGCACTGAGGGAGTGATGAATTCTTAACTGGGGATGGTGGGAGGCTTCGAGTGGGAGGTGGCA
TTTGAGCTAGGCTTTGAGAGAGGAGCAGGTATTGCACTTGCATTTAGGTAGAAAGCATTGGGGTGCAAGG
TGACACTGGAGGGGGAGGCATCAGGAAATCCAGGATGTCTTCAAAGTTCTGGTGTCGGGGGCTGTTGAGT
AAGCACAGGAATAAGGGGGTCAAGTTAGAGTCAGGGTGGGGTCTGACCTGGATGCCATAGGACCTGATCC
CCAAGCCACAGGGTGGGACTTGACTGGGCAGTGGGGACCTTTGGAAAGGACTTTGGGGAGAAAAACAGAC
TGGAGTCTGTCTTAGGCGATCATCGGTCCGTGAAATGAGCATGTGTTACAGGCTTGGTATGTACCAGACC
CTGTGCTAAGCAAGGGGGTATGGAGAGGAGAGGGTGACAAGAATATTGGATCAACACCCGGGAGCTCCAT
CTATCCCAGGATGCACTATCTTTTTTTTATTTTTTTGAGACGGAGTCTCACTCTGCCTGCAGGCTGGAGT
GCAGTGGCTCCATCTCGGTTCACTGCAACCTCTGCCTCCTGGGTTCAAGCGCTTCTTGTGCCTCAGCCTC
CCAAGTAGCTGGGATTACAGGCACATGCCACCACACCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGG
TTTCACCATGTTGGCCAGGATGGTCTCGATCTCTTGACCTCAAGATCCGCCCACCTTGGCCTCCCAAAGT
GCTGGGATTACAGACATGAGCCACCGTGCCCAGCCAGATACGCTATCTTTTTATTGAGTGATTGAGACAG
GGTCTTGCTCTCTTGTCCAGTCTTGAATGTGGTGGTGTAATCACAGGCTCACTGCAGCCTTGACCTCCTG
GGCTCAAGTTACCCTTCTGCAGTAGCTGGGACTATAGGAGCGTGCCACCACGCCTGGGTAATTTAAAAAA
TTTTTTTTGTATAGACAGGGTCTCACTATGTTGCCCGAGCTGGTCTCAAACTCGTGGGCTCAAGTGATCC
TCCAGTTTTGGCCTCCCAAAATGTTGGGATCACAGGAGTGAGCCACCACTCCTGGCGATGAGCCAAGTCT
TTTTTTTTTTTTTTTTTTTTTGATATGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAATGACACGATC
TTGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGCAGTTCAAGCAATCCTCCTGTCTCAGCCCCCCAGT
AGCTGGGATTACAGGCATGCGCTACCACGTCCGGCTAATTTTTGTATTTTTAGTAGAGATGAGGTTTTGC
CATGTTGGCCAGGCTGGTCTTGAACTGCTGACCTCAGGTGATCCACCTGCCTCGGCCTCCCAAAGTGCTG
GGATTACAGGTGTGAGCCATCGTGCCTGGCGGAGCCGAGTCTTAAAAGATGACCCTGTGGAGAAATGGTG
GTCCAGGCTGAAGGGACAGCCTATGCAAACACTGGGAGGTGTGGAAAATCATGACCTGTGGGTGGAAATT
TTGGCTAGAACATCAAAATCATCAGGTGTACATTCCTGTACCCATGCAGCAGTCAGAATCTCTGGGGGTG
GGGCCCCAAAATTGTATGCATACAGACTGTGTGCTGATTTGTGATATTACTTAGGATTTTTTGACTTTAC
AATGGTGGAAAAGCAATAATATACATTCAGTATAAACCGTACTTTGAATACCCATACAGCCATTCTGTTT
TTCACTTTTATTTTTATTTATTTATTTATTTATTATTTATTTTGAGATGTCATTTTGCTGTTGTTACCCA
GGCTGGAGTGCAATGGCGCAGTCTTGGCTCACCGCAACCTCCACCTCTCAGGTTCAAACGATTCTCCTGC
TTCAGCCTCCAGAGTGGCTGGGATTACAGGCAGGCACCACCACACCCGGCTAATTTTGTATTTTTAGTAG
AGACGGGGTTTCTCCATGTTAGTCAGGCTGGTCTCGAACTCGAGAGCTCAGGTGATCTGCCCATCTCAGC
CTCAAGCCACCATGCCCAGCCCTACTTTCAGTATTCAATAAATTACATAGCCAGGCACCGTGGCTCACAC
CTGTAATCCCAGCACTTTAGGAGGCCAAGGTGGGAGGATCCTTTGAGGCCAGAAGCTCGAGACCAGCCTG
GGCAACATAGTGAGACCCCATTTCTACAAAAAATAAAAAAACTAGCTGAGTGTGGTGGCGTGTGTCTGTA
GTCCCAGCTACTTGGGCAGCTGAGGTGGAAAGACTGCTTGAGCCCAGAGGTCAGGGCTGCAGTGGGCCAT
GATCTCACCACTGCACTCAGCCTGGGCAACACAGCAAGGCCCTGTCTCAAAAATAAATAAATAAATAACA
CAAACTTATTTAACAGTTTACTATAAAATAGGCTTTGTGTCAGATGATTCTGCCCAACTGTAAGCTGCTG
GCAGTGTAAATGTTCTGAGCACGTGTAAGCCAGGCTAGGTGTCTTAAATGCATTTTCAGTTTCAACTTAG
AATTGGTTTATCAGGACGTAGCCCCTTGGTGTTGAGGGGCATGTGTATTAACAGTCTCCTTAGTGACTTT
TTTTTTTTTGAGATGGAGTCTTGCACTGGCCGTAGTGCAGTGGCACAATCTCAGCTCACTGCAACCTCTT
GTCTCCCGGGTTCAAGCGATTCTCCTGCCTCAGTCTCCCAAGTAGCTGGGATTACAGGCACCCACACCAC
GCCCAGCTAATTTTTGTGTGTGTGTATTTTTAGTAGAGACGGGGGTTTCACTATGTTGGCCAGGCTGGTC
TCGAACTCCTGACCTTGTGATCTGCCCACCTCAGACTCTCAAAGTGCTAGGATTCCAGGCATGAGCCACC
GCGCCCAGAGTCCTTAGTGATTTTTACACCATGAATTGTTGAAGCCCTAAGCCAGAGCCAAGGGCAAGAG
TATAGAGAATCTGGAGATGCGGAGAGGGTTCTGATTGCCTACAAGGAGTTTGGACTTTATTGTGGAGGCA
GCGGGGAGCCAAGGCAGGTTTTAGAGTAGGAGAGGGTCCAAGCCTGTGGGTCACCCTTCCGACTTCCCTT
TCCGAATGCCAAACACCTTCATGTCCCCCGTGGGCCCCCTTTGTCCCTCCCACCCCAAACTAGCCCTCAA
TCCCTGACCCTGGCTTCCGCCCCCAGCCCTCTGACGTCCATCATCTCTGCGGTGGTTGGCATTCTGCTGG
TCGTGGTCTTGGGGGTGGTCTTTGGGATCCTCATCAAGCGACGGCAGCAGAAGATCCGGAAGTACACGAT
GCGGAGACTGCTGCAGGAAACGGAGGTGAGGCGGGGTGAAGTCCTCCCAGCCCGCGTGGGGTCTGCACCG
GCCCCCGGCACTGACCCACCACCCCCTCACCCCAGCTGGTGGAGCCGCTGACACCTAGCGGAGCGATGCC
CAACCAGGCGCAGATGCGGATCCTGAAAGAGACGGAGCTGAGGAAGGTGAAGGTGCTTGGATCTGGCGCT
TTTGGCACAGTCTACAAGGTCAGGGCCAGGTCCTGGGGTGGGCGGCCCCAGAGGATGGGGGCGGTGCCTG
GAGGGGTGTGGTCGGCAGTTCTGATGGGAGGGGCAAGAGCTGGAGGCAGTGTTTGGGGGAGGGCAGTTAC
AGCGGAGAAGGGAGCGGGGCCAAGCCCTAGGGTGGTGAAGGATGTTTGGAGGACAAGTAATGATCTCCTG
GAAGGCAGGTAGGATCCAGCCCACGCTCTTCTCACTCATATCCTCCTCTTTCTGCCCAGGGCATCTGGAT
CCCTGATGGGGAGAATGTGAAAATTCCAGTGGCCATCAAAGTGTTGAGGGAAAACACATCCCCCAAAGCC
AACAAAGAAATCTTAGACGTAAGCCCCTCCACCCTCTCCTGCTAGGAGGACAGGAAGGACCCCATGGCTG
CAGGTCTGGGCTCTGGTCTCTCTTCATTGGGGTTTGGGGAGATATGACTCCCGCAAACCTAGACTATTTT
TTTGGAGACGGAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCGTTATCTCGGCTCACTGCAACCT
CCACCTCCTGGACTCAAGCGATTTTCATGCCTCAGGCTCCTGAGTAGCTGGGATTACAAGCGCCCGCTAA
TTTTTTTTTTTTTTTTGAGACAGAGTCTCGCTCTGTCACCCAGGCTAGAGTGAAATGGTGCGGTCTCAGC
TCAGCCTCCCAGGTTAAAGCGATTCTTCTCCCTCAGTCTCCTGAGTAGCTGGGATTACAGGCGCGAGCCA
CCACGCCCGGCTAATTTTTGTATTTTTAGTAGAGATGGGATTTCACCATGTTGGCCAGGTTGGTGTCAAA
CTCCTGACCTCATGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGTGCC
CGGCCTAATCTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGTCCAGGCTGGTACTTTGAGCCTT
CACAGGCTGTGGGCCATGGCTGTGGTTTGTGATGGTTGGGAGGCTGTGTGGTGTTTGGGGGTGTGTGGTC
TCCCATACCCTCTCAGCGTACCCTTGTCCCCAGGAAGCATACGTGATGGCTGGTGTGGGCTCCCCATATG
TCTCCCGCCTTCTGGGCATCTGCCTGACATCCACGGTGCAGCTGGTGACACAGCTTATGCCCTATGGCTG
CCTCTTAGACCATGTCCGGGAAAACCGCGGACGCCTGGGCTCCCAGGACCTGCTGAACTGGTGTATGCAG
ATTGCCAAGGTATGCACCTGGGCTCTTTGCAGGTCTCTCCGGAGCAAACCCCTATGTCCACAAGGGGCTA
GGATGGGGACTCTTGCTGGGCATGTGGCCAGGCCCAGGCCCTCCCAGAAGGTCTACATGGGTGCTTCCCA
TTCCAGGGGATGAGCTACCTGGAGGATGTGCGGCTCGTACACAGGGACTTGGCCGCTCGGAACGTGCTGG
TCAAGAGTCCCAACCATGTCAAAATTACAGACTTCGGGCTGGCTCGGCTGCTGGACATTGACGAGACAGA
GTACCATGCAGATGGGGGCAAGGTTAGGTGAAGGACCAAGGAGCAGAGGAGGCTGGGTGGAGTGGTGTCT
AGCCCATGGGAGAACTCTGAGTGGCCACCTCCCCACAACACACAGTTGGAGGACTTCCTCTTCTGCCCTC
CCAGGTGCCCATCAAGTGGATGGCGCTGGAGTCCATTCTCCGCCGGCGGTTCACCCACCAGAGTGATGTG
TGGAGTTATGGTGTGTGATGGGGGGTGTTGGGAGGGGTGGGTGAGGAGCCATGGCTGGAGGGAGGATGAG
AGCTGGGATGGGGAGAATTACGGGGCCACCTCAGCATGTGAAGGGAGGGAAGGGGCTGCCTGTGCCCCAC
CTTGCAGGGTCTGTGCACTTCCCAGGATTAGGGAAAGACCGGGTAGGGTCTGTCTCCTGGCATCACATCT
CCCCCTGCTACCTGCCATGATGCTAGACTCCTGAGCAGAACCTCTGGCTCAGTACACTAAAGCTCCCTCT
GGCCCTCCCACTCCTGACCCTGTCTCTGCCTTAGGTGTGACTGTGTGGGAGCTGATGACTTTTGGGGCCA
AACCTTACGATGGGATCCCAGCCCGGGAGATCCCTGACCTGCTGGAAAAGGGGGAGCGGCTGCCCCAGCC
CCCCATCTGCACCATTGATGTCTACATGATCATGGTCAAATGTGCGTGGCTGAGCTGTGCTGGCTGCCTG
GAGGAGGGTGGGAGGTCCTGGGTGGAGGAGCCCACAAGGGGCATGAAAGGGGACCAGGATGTATGTAGAC
CCAGGAGCCCTAGTATGTTAGGAGCCTCAAAACCTTCTTGTATCCCTTTTACAGTCAAAGTCCAAAGCCA
CTCTTGAGGAACACTCTTGTACAAAATTAAGCTGGGCACAGTGGCTCATGCCTGTAATCCCAGTACTTTT
GGAGGCTGAGGTGGGAGGATCCCTTGAAGCCAGGAGTTCAAGACCAGCCTGGGCAACATAGTGAGATCCT
ATCTCTACAAAAAATAAAAAAATTATCTGGGTGTGGTGGTGTGTGCCAGTAGTCCCAGCTACTCAGGAGA
GGCTGAGGCAGGAAGATCACTTGAGCCTAGTTTAAGGTTGCAGTAAGCTATGATTGCACCACTGAAATCC
AGCCTGGGTGACAGAGCGAAACCTCATCTCAAAAAAATAAAAAAGCAAACAAAAAGAAAAAAAAAATTAA
AAGGGAAACTAGAAGAGATGCCAAAGGTTCTGGCTGAAGACCCCAGAGTCTGGTGCTACTTCTCTACCAC
CTGAGGGCTTTGGGCTGTCCCTTGGGACTGTCTAGACCAGACTGGAGGGGGAGTGGGAGGGGAGAGGCAG
CAAGCACACAGGGCCTGGGACTAGCATGCTGACCTCCCTCCTGCCCCAGGTTGGATGATTGACTCTGAAT
GTCGGCCAAGATTCCGGGAGTTGGTGTCTGAATTCTCCCGCATGGCCAGGGACCCCCAGCGCTTTGTGGT
CATCCAGGTACTGGGCCTCTGTGCCCCATCCCTGCCTGTGGCTAAGAGCACCCTCCTGCAGAGGGTGGGA
AGGAGAGATGAGTCCAGTATGCCAGGCCCCTCACGGAAGGCTGCATGCTGGGCTGGGGAGGGGCCACCAT
CCTGCCTCTCCTTCCTCCACAGAATGAGGACTTGGGCCCAGCCAGTCCCTTGGACAGCACCTTCTACCGC
TCACTGCTGGAGGACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTATCTGGTACCCCAGCAGGGCT
TCTTCTGTCCAGACCCTGCCCCGGGCGCTGGGGGCATGGTCCACCACAGGCACCGCAGCTCATCTACCAG
GGTCAGTGCCCTCGGTCACACTGTGTGGCTGTCTGCTTACCTCCCCCAACCCCGGTGGACTAGGGTCCCT
TTCTCTGATGTTCCCTCAACTGTCACCTCTCAAGGAAACCCCATTATCCCTACAAAAAATTCTTACTGCC
TTCCAACCCCTGTGACCCCATTCTCTCCACGGTGACTGTGTCATACCCCAAAGGTGACCTCTGTTTTTCT
CCTGTGACCCTGTCACCTTCCATGGAGTCCCCATCCCAGATCCGTGAGTGACCCCCATCATGACTTTCTT
TCTTGTCCCCAGAGTGGCGGTGGGGACCTGACACTAGGGCTGGAGCCCTCTGAAGAGGAGGCCCCCAGGT
CTCCACTGGCACCCTCCGAAGGGGCTGGCTCCGATGTATTTGATGGTGACCTGGGAATGGGGGCAGCCAA
GGGGCTGCAAAGCCTCCCCACACATGACCCCAGCCCTCTACAGCGGTACAGTGAGGACCCCACAGTACCC
CTGCCCTCTGAGACTGATGGCTACGTTGCCCCCCTGACCTGCAGCCCCCAGCCTGGTATGGAGTCCAGTC
TAAGCAGAGAGACTGATGGGCAGGGGAGGTGGGACCTTCAGCCCAGGGTCCACTGTGGGGGCAGAGGGAG
TGGCAGAGACACCGGGGTTCCTTCCCCTAATGGGTCACCTTCTCTTGACCTTTCAGAATATGTGAACCAG
CCAGATGTTCGGCCCCAGCCCCCTTCGCCCCGAGAGGGCCCTCTGCCTGCTGCCCGACCTGCTGGTGCCA
CTCTGGAAAGGCCCAAGACTCTCTCCCCAGGGAAGAATGGGGTCGTCAAAGACGTTTTTGCCTTTGGGGG
TGCCGTGGAGAACCCCGAGTACTTGACACCCCAGGGAGGAGCTGCCCCTCAGCCCCACCCTCCTCCTGCC
TTCAGCCCAGCCTTCGACAACCTCTATTACTGGGACCAGGACCCACCAGAGCGGGGGGCTCCACCCAGCA
CCTTCAAAGGGACACCTACGGCAGAGAACCCAGAGTACCTGGGTCTGGACGTGCCAGTGTGAACCAGAAG
GCCAAGTCCGCAGAAGCCCTGATGTGTCCTCAGGGAGCAGGGAAGGCCTGACTTCTGCTGGCATCAAGAG
GTGGGAGGGCCCTCCGACCACTTCCAGGGGAACCTGCCATGCCAGGAACCTGTCCTAAGGAACCTTCCTT
CCTGCTTGAGTTCCCAGATGGCTGGAAGGGGTCCAGCCTCGTTGGAAGAGGAACAGCACTGGGGAGTCTT
TGTGGATTCTGAGGCCCTGCCCAATGAGACTCTAGGGTCCAGTGGATGCCACAGCCCAGCTTGGCCCTTT
CCTTCCAGATCCTGGGTACTGAAAGCCTTAGGGAAGCTGGCCTGAGAGGGGAAGCGGCCCTAAGGGAGTG
TCTAAGAACAAAAGCGACCCATTCAGAGACTGTCCCTGAAACCTAGTACTGCCCCCCATGAGGAAGGAAC
AGCAATGGTGTCAGTATCCAGGCTTTGTACAGAGTGCTTTTCTGTTTAGTTTTTACTTTTTTTGTTTTGT
TTTTTTAAAGATGAAATAAAGACCCAGGGGGAGAATGGGTGTTGTATGGGGAGGCAAGTGTGGGGGGTCC
TTCTCCACACCCACTTTGTCCATTTGCAAATATATTTTGGAAAACAGCT

Protein Information

Protein Name

transcript variant 3

NCBI Protein GI

54792098

Protein Accession

NP_001005862

Protein pI

5.82

Protein Weight

126717.24

Protein Length

1225

Protein Note

Also known as NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu

Protein Sequence

>NP_001005862.1 receptor tyrosine-protein kinase erbB-2 isoform b [Homo sapiens]
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLR
IVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWK
DIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQC
AAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGS
CTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPES
FDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGI
SWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHC
WGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHY
KDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVG
ILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGA
FGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQL
MPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLL
DIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGER
LPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLE
DDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEG
AGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPP
SPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNL
YYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV

Epitope Information

IEDB Linear Epitope