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CEACAM3

General Information
Protegen ID 316
Sequence Strain (Species/Organism) Homo sapiens
Taxonomy ID 9606
Molecule Role Protective antigen
Molecule Role Annotation The immunogenicity of the nominal antigen, carcinoembryonic antigen (CEA) has been studied, as well as that of an anti-idiotype antibody, 3H1, which mimics CEA and can be used as a surrogate for CEA. It has been demonstrated that immunization of CEA transgenic mice with bone marrow-derived mature dendritic cells (DC) loaded with anti-idiotype 3H1 or CEA could reverse CEA unresponsiveness and result in the induction of CEA-specific immune responses and the rejection of CEA-transfected MC-38 colon carcinoma cells, C15 (Saha et al., 2004).
To improve the antigen delivery into DCs, CEA conjugated to a protein-transduction domain, human immunodeficiency virus transactivating Tat was utilized. Furthermore, the truncated non-glycosylated CEA from Escherichia coli was purified to overcome the safety concerns and immunosuppressive functions associated with the native CEA protein.CEA-specific T cell proliferation and cytotoxic T cell responses were enhanced significantly in mice immunized with Tat-CEA-pulsed DCs [DC (Tat-CEA)] compared with those immunized with CEA-pulsed DCs [DC (CEA)]. T helper type 1 responses were more prominent in the DC (Tat-CEA) immunized mice whose splenocytes secreted more interferon-gamma and less interleukin-4 than those from DC (CEA) immunized mice. In vivo, the DC (Tat-CEA) vaccine delayed tumour growth significantly and prolonged survival of tumour-bearing mice (Bae et al., 2009).
References
Bae et al., 2009: Bae MY, Cho NH, Seong SY. Protective anti-tumour immune responses by murine dendritic cells pulsed with recombinant Tat-carcinoembryonic antigen derived from Escherichia coli. Clinical and experimental immunology. 2009; 157(1); 128-138. [PubMed: 19659778].
Saha et al., 2004: Saha A, Chatterjee SK, Foon KA, Primus FJ, Sreedharan S, Mohanty K, Bhattacharya-Chatterjee M. Dendritic cells pulsed with an anti-idiotype antibody mimicking carcinoembryonic antigen (CEA) can reverse immunological tolerance to CEA and induce antitumor immunity in CEA transgenic mice. Cancer research. 2004; 64(14); 4995-5003. [PubMed: 15256474].
Gene Information
Gene Name CEACAM3
NCBI Gene ID 1084
Genbank Accession AC022516
Chromosome No 19
Gene Starting Position 41796589
Gene Ending Position 41811552
DNA Sequence 
>NC_000019.10:41796589-41811552 Homo sapiens chromosome 19, GRCh38.p12 Primary Assembly
CAGAGCCTAAGTCACAGTAGCCCTGACTACAGCATTCCTGGAGCCCAGGCTCTTTTCCACAGAGGAGGAA
AGAGCAGGCAGCAGAGACCATGGGGCCCCCCTCAGCCTCTCCCCACAGAGAATGCATCCCCTGGCAGGGG
CTTCTGCTCACAGGTGAGTGGAGGATTCCTGGGAGTGGGCAAGAGGAGGGATCACAGAGAATGGCTGGGG
TCTCCTGGGGAGGATGGGGCTCTGATAGGGGACAGAAGGCTTCTGCTGAAGCCTCAGGGGAGAGAACATC
AGAGAGGGACACGGGTCACAACAAGACAATCACATTGAACTGGGATTGATAAGAGGGAGGAAAATCCATT
GATCATGTTTTCCAAGTTAATCATTACTGGCCACTACAATTAGAAAATGATAAGAATAAGAATTACATCA
GGGTGATACTTTAAATAAAAATATAACCAGGGCACTAAAACCTGTCTTTGACCACCAACCACAAGTTGCA
AAATAACCACCACTCCTTAACTCATCCACCAGTATTTGCAATCAAATTTTAGGCACTGGCGTACAACAAA
TATCAGACAAGTCTCTGTGTTCAAAGAGCTTACACTCTTGCAGAGATGAAGATAGACACCCAAAGAGATC
TAGAATGTGAGTTCAGGTGTTGACAAGAGCCCTGGAGGGAACAGAGCAGAAAAAGGTCAGAAAGGGAAGA
CCCAGGGTCTCTAGAGGAGGTGTCAGGGGAGGGATCTCCCAAGGATGCCCTGATGTGAGCAGGATCTGAG
GGCAGTGGGGAGGGAGCCATGCAGACCCCTGGGGAAGGGGATTCCACACAGGAAAATGCCAAGGTTAGAG
GTGCTGAAGAAAGAAAGGTCACGTTACTGACCTTGACCAAGTGGGACACACATACACTCTCCAAGGCTGA
AGGGTGAAGAGACTCTCTCAGGACCCAGGGCCCCATCTTTCCATCCCAATACATGGGTCCCAATATTGAC
TGATGCTTTCTCCCTCCTAGCCTCACTTCTAAACTTCTGGAACCCGCCCACCACTGCCAAGCTCACTATT
GAATCCATGCCGCTCAGTGTCGCAGAGGGGAAGGAGGTGCTTCTACTTGTCCACAATCTGCCCCAGCATC
TTTTTGGCTACAGCTGGTACAAAGGGGAAAGAGTGGATGGCAACAGTCTAATTGTAGGATATGTAATAGG
AACTCAACAAGCTACCCCAGGGGCCGCATACAGCGGTCGAGAGACAATATACACCAATGCATCCCTGCTG
ATCCAGAATGTCACCCAGAATGACATAGGATTCTACACCCTACAAGTCATAAAGTCAGATCTTGTGAATG
AAGAAGCAACTGGACAGTTCCATGTATACCGTGAGTATTTCCACATGACCTCTGGGTGTTGGGGGTCAGT
TCTACTTCCCACATATGGGATTGTCAGGCCTGGGCTGTGCCTGTGGCCCTCTCTGCATTACATTCTGTAT
CAGGGTTTGGACATTTAGTGCAGGACACACACGGGGGAGACAAACTTCCACAGATCAGAATTCCTTTCCT
GCATCCAGACCCTGCAGACACTCGCTGCAGAGGAAGGACAGTCTGATGGGGGGACTCAGCAGGGCAAGGT
CAGTGTCAGAAAAGAACCCCATGGTCTCCCCATGGACCTGACCCTAAGAAAGACCCTGGAGAACTGGATC
AGGGCCTGGCCTGAGGGGTCCCCCTAGGATTCTCAGAGAGAAGCTCAACTCTTCCCAGAACTGAGCCCCT
GTGCAAATCCCTGTCCCAGATTCCTGACTCCAGGTGACCCTGGGGACCCTAGGGATCCTGTGCCAGGGCT
GAGTGAGGCCTCCTGGGCAGGGCTGACTGGGAGCAAGAATTTACCAGCTGTCTGAGGGTCGTGGCTCCTG
GAGTTGGTCACCAGCCAGGGTCCAGCCCCAAGAACCTCTCCTGGGCAAGGACAGGGCCTCATCCTTTACC
TGAGACTCAGCATGGAGTGAACAGATGGACAAGATTACTAGGGCATGAGCCCACTGCCCAGGGGAACTTA
GATGACTCCATGGGAAGTTCAGTATCCCCAGGGGGAGGAAAAAGAAGAGAGAAGATGCTCCCAGCAGCTC
CTTTTCCACAAGGGATCAGACTCAGGGACCTCTCTTTTGGAGGCAAATAAGCATAGATGCTGTTCCTTTG
GGCAGCTCCTCTATACACAGCTGAGGTCAAGTAATTGTAAATATTTTGAGATTAATTCACAAACAACGTC
ACAGCCAAATAGCACTTATCCTACTTATTGAAAAAAAAAATTGAGGAACAGGGAGACAGTCACCGACTAG
GGTCACACAAGTCAAAGGTGTCAGATTAGAGTCACACGAGGTCTCTCTGCAGCCACAGCTGCCTCTTCTC
CACCAGGGGACGGCTGGCGTTATTATTAGACATCTGCAGGCCTGAGACCAGTCCTAAGTTCTCTTTCCTT
TTTCTTGGGCATCCACATCTCAGAGGGGGAGATTTTGGTCTGGAGAGTAAGGGGCAAATGGAAAATTAAT
CAATTTTTCCTGATATAGTTTGGATGTTTATCCTCTCCAAATCTCATGTTGAAATGTGATCCCCAACATT
GGAGGTGAGGCCTGGTGGGAGGCGATTGGATCATGGGGGGCTGTTTCTCATGAGTGGCTCAGCACCATCC
CCTTGGTGACAAGTCAGTTCTCACTTTGAGTGCACAGGAGATCTGGTTCTTTAAAAGTGTGTGGCGCCTC
CACACTCTCTCTTGCTCCTGCTTTTGCCACATGACACCACCTGCTCCCCCTTCTCCTTCCACCATGATTG
TAAGCTTGCTGGGTCTCACCAGAAGCCGAGCAGACGCTGGTGCCATGCCTGTATAGCCTGCAGATCCCTG
CATCAATTAAATCTCTTTTCTTTATAAATTACCCAGCCTCAGACATTTCCTTATAGTAACAAAAAATAGC
CTAACACATTAGCCTAACCTAGAACTAAATCCCTTGTGTCAACAGAGTCAGTGCCAGGAATGTCCGGGCC
TCCCTCTCAGATGCGCACCACTGCCCTCACTCGACCTGAAATCCTGTGTTTCCTGATGTGTCAGTGACAC
TCCCACAGGAGGATAAAACACTCCCCACTCACACCCTGCACCAGCGCAGGGCCCAGTGAGAGACACACAC
TCAGTAGTTCTCTGACGAAGGAGGGAAGGAATGAATGATGAATAATTCTTAAACTCTTCAGAGACCGGAT
CTTGGATGCAGAATCCTATAAGGTTCTGGCCACACCTGTTTCCTGTCCCTCCAGGGGCCGGGATCCTTGT
TGCATTCCTCTAACCCCTGCCCCTAAAGCTACCCCAAGAACCGCATCTCATGGGACTCTGGCACAGCTCA
CCTGTGGGAAGGTTTTCAGGTCTCCCTGGTCCTGGTTTGTGGGCGGCAGGTCACCCAGGCGCCGAGGCAA
GAGACCAAGGACACGAGCTGTTCCAGTATAATAAAATATAAAACAAGAAAAGTTATACCAGATATAGATC
TTAGATATGATTATATGTGAATATCATTAATCATTAGTTGGTAGCAATTACTCTTTATTCCAGTATTATA
ATAATCCTCGCTCTATAATCACAACCTAGGAAAAGCCAGGCCATACAGAGATAGGAGCTGGGGAGACATA
GTGAGAAGTGACCAGAAGACAAGAGTGCGAGCCTTCTGTTATGCCCAGACAGGGCCACCAGAAGGGCTCC
TTGGTCTAGCGGTGACACTAGCGCCTGGGAAGACGCCCGTTGCCAGGCAGACCGAGGTCTAGCGGTAGCG
TAAGTGTCAAGGGAAAACACCCGCTACTTGGCAGACCGGGAAAGGGAGTCTCCCTTTCCCCGGGAGAGTT
TAGAGAAGACTTTGCTCCTCCACCTCTTGTGGAGGGCCAGACACCAGTCAGGTCCACTCGCAGTTATCCG
GAGGCCTAACCGTCTCCCTATGATGCTGTGCTTCAGTGGTCACGCTCCTAGTCCGCCTTCACGTTCCATC
CTGTACGCCTGGCTCTGCCTTCTAGATAGCAGTAGTAAATTAGTGAAAGTACTAAAAGTCTCTGATATGC
AGAAATAATGGCATAAGCTGTCTTTCTCTTTGTCTCCTCTCTCTCTCTGCCTCATCTGCCAGGCAGGGAA
GGGCCCCCTGTCCAGTGGACACATGACCCACGTGACCTTACCTATCATTGGAGATGACTCACACTCTTTA
CCCTCCCCCTTTTGCTTTGTATCCAATAAATAACAGCGCAGTCAGACATTCGGGGCCACTACCAGTCTCC
GCGCATTGGTGGTAGTGATCCCCCCGGGGCCCAGCTGTCTGTTCTTTTATCTCTTTATCTTGTGTCTTCA
TTTCTACACTCTCTCGTCTCCGCACATGGGGAGAGACCCACCGACCCTGTGGGGCTGGTCCCTACACTGG
TTCTAGAATAACCAGGGGTCTCCTGGTCCCTAGGGTCTCTGAGGTCACTGTAGTCCCCACAGCTCACTGT
GATGTAATCTCTGGCTATCTCTGCTACCCCTTGTCCCTTATCTTCCTCCCCTTTCACACCAGTGAGGATG
CCCCTGCCCTGCACAGCTTCCTCCACCCTTAGGTCTTCCCCAGGAACTCCCTCTAACAAGACTGGCTGTT
CTGTTCCCTTCCCACTCACACTGTGGCCTGGCCCACCTCCGGGGCAATAAAAAAAGGCACAGAAATCAGC
TGGATCAGAGCCCCTGCCAGGCTTCATCATGAGCCAGTGTCCCCAGGCCACCAGGAGAACGAGCTTCCAC
TGTGTCCCCACCCAGGGCTCTTTCCCTTCTTGAGGCCAACATGTGGAAAAGGCCACAGGACAGGGACGAG
CGACTCCTCCACCTACTCTTGTAATTTCCCAGCAGGTTTTTCCTGCCACTGCACAGACAAAACCAATTCA
CTGAGACCACGATATTGCAGTCAAGAAAGAGTTTAATTAATGCTAAGTAAGCCAAACAGTAAGACAAGAG
TTTATTATTACTTAAATCAGCCTCCCTGGAGGCTTGAGATTAGAGTTTTTCATGGATAGTTTGATGGCAG
GGGACTAGGGAATGGGGAAAGCTGATTGGTTGGGGATAAAATCATAGGGATGTGGCAACTGATCCTGGTG
TGCTGAAACTGCCTCTGAGTGGGGGCCACAAGACCACTGAATCATGGGTCACAGTCCAGGTGGAGTCAGT
CAGTTGCCAGAATGCAGAAGTCTGAGAAACATCTCAAAAGACCAATCTCAGGTTCTACAATAGTGATATT
ATCTATGGGAGCAATTAGGGAAGTCACAAATCTTGTGACCCTCCCATAATGCTGATCTCGTAATGTTTCA
TTAGTTTACAAAGGCAATCCCTGACAAAGAGGAAGTTAGTTTTAGGGAGGGACTATAATCATCCTTGCTT
CAAAGTTAAACTATACACTGAATTTTTCCCATGGTTAGCCTGGCTTGTGCCCAGGAATGAGCAAGGACAG
CCACCTTGAGGCTAGAAGCCAGATGAAGTCAGCCATGCTAGCTTACTCTCGCCATCTTAATCCTTGCAAA
AGTGGTTTCACTCTCTACAATGACTCACCAGGGGTCAGAGGCAAGAGGAGAGGTCTGCAGTCCCCAAAGC
TCATGGCTCATTTCACCCATTTCCCTCCCGACTCCACCCTCATTCAGCTATGGGGCTCCCATCCTCCAGT
CATTCCCTAGAGACTTCTGGTGTCCAATTTGGCATGTAAGAAGCTTGAAATCTGTCACTCAGTTATAACA
AGTATAAAACTGAACAAACTGAAAAATCAACAACTCTTTTAGATCCCTCAGAGAAGCTAGGCCTCGGTGT
TAATTGCCCCGCATATTGGAGAGACCGACAGGCAAAGATGGAGCAGCACACCTCACCTGGGCAGAAGCCC
AGGGACAGAAACCCTGCAGAACCAGCGCTGGGGTCAGAAATCTGAACTGTAACTGACAAATTGCTGGAGG
CTCAGCATGGACATGCCCCAGAGTTAAACTAAACACTCCAGGGGAGGGATCAATCTTGGGGCTGGGACAA
GGAGGGACTCTTTTGTGAGTCTTAACTCCTAGAGCTACCAGATTCTCATAGTGAATAGGCAACAAAGATC
CCCTCCTCCTTCCTGAAGCGGGAGGGGGAAAGGAATTATTTGGAAAGATCTCCGTGAATTCTATTCTTCT
TAGCAACAGCTGCCTTTAAGAGAAACTTTTACCAGAGCCTGACCTGCTGGGGTTTTATGGGAGCCTAACT
GGCCTGGCAGTGGGTAAATGTCCAACTCCAGCCCCCTGTAGCCATCATGTCCCACCTAAGGGGGCAAAAA
TACAGAGAGTCACTTATGAAGTTCACAGCCCAGGCTGCAGACCTCATCCAGGACCACAGAACCCTTCCCT
CCCAACACTCACCACAGCGTCACTGAACACCTGCTCACCCAAGTTCCTTTTACCCAGAATATCATGTCTG
GCTTTCAACAAAACTGCACAAGACAGACTAAGGCAAAAACAAAAAAAAATGCAATTTGAAACTCAGAACA
ACAATCAGAACCAGACTCAGATGTGGCAGGGATGTTGAAATTAGCAGAACGGGAATTTAAAACAACTCTG
GTTAATACAGTAAAGGTTATGATGGAAAAAGTAGACCCCATGCAGGAACAGATGGGTGATGTAAGCAGAG
AGATCGATATTCTAAGACAGAACCAAAAGAAATGCTAGAGATAAAAAAAGAAACCCTCCTGTAAGGTAAA
TGAAGAATGCCCTCAATGGGCTTACTGGTAGCCTGGACACAGCTGAGGAAAGAATCTCTAGCTTGAGGGT
GTGTCAGTAGAAACTTCCAAAACTGAACAGCAAAGTTTTGTGTGTGTATGTGTGTGTGTGTGTGTGTGTG
TGTGTGTGTGTTGTTTTGTTTGTTTTTTTTTTTTTTGAGACAGAGTCTCGCTCTGTACCCCAGGCTGGAG
TGAAGTGATGCTATCTCAGCTCACTGCAAGCTCTGCCTCCTGGGTTCACGCCATTCTCCTGCCTCAGCCT
CCCAAATAGCTGGGACCACAGGCGCCCGCCACCATGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACGG
AGTTTCACCGTGTTATCCAGGATGGTCTCGACCTCCCAACCTCATGATCTGCCCGCCTTGGCCTCCAAAA
GTGCTGGGATTACAGGCATGAGCCACCATGCCCGGCCTGAAACAGCAAAGCTTTAAAAGAGTGGGAAAAG
GCCGGGCGTGGTTGTTCATGCTTGTAATCCCTGCACTTTGGGAGGCTGAGGCGGGTGGATCACCTGAGGT
CAGGAGTTCGAGACCAGCCTGGCCAACATGATGATACCCTGTCTCTACTAAAAATACAAAAAATTAGCCA
GGCATGATGACAGATGCCTATAATCCCAGCTACTCAGGAGGCTGAGGCAAGAGAATTGCTTGAACCTGGG
AGGTAGAGATTGTAGTGAGCCAAGATAGCGCGATTTCACTCCAGCCTGGGCAACAAGAGCAAAACTCTGC
CTCAAAAAAAAAAAAAGAGTGGGTAAAAAAAGTGGAAAAGCAGATTCAACTTCACATTCAAGATTTTGTA
TTGACAATGGCATATTTTATATTTTCTAAAAGCTGTAACATACATGTAATGGGAATACTGGTGGTTCCTG
GGACCAGGTGGAGCTGGCCAGCCCTGTGCTGTCTGATGGGCCCACTGCTTGTTCCACACACATGTGTCCC
TCATGATGATGCCATTATCATAAGATGGGGTCTTCGGGTGGGGAGATGCACCAGCCACCGGCATCTCACT
TAGACTCTGCCCAATTCGGGCTAATTTAATCAAATTCTAGTTGTGTTTCCTGAGGCGTAAAGAAAAGGAG
GAAGGTGTTTCATATGCCTGTTTAGGCCCCTTCCTATTTTGCCTAACTCTGCACAGGAAATTGAGGTGAG
GGCTCTTTTGACATTTACTGACATACACACATCACATCTCCTAATTTGGTATTTTTCTTTTCTGTGTATT
ATTGAGACATCTCAGACTTTCCCTCTGACCAGTTCTGTCTTCCTAACAGGACTCACAATTCTCTCTCTAC
CCAGAGAGTCACTGATTTCAAACCAAAGTCAGCATCTTTCTTTGAGCTTAACATGATTATGCTGGTCTTC
AGCATTTAGCAGACCTAAACCTTATTATGTTATCAAGAGAAATGCTACAGCAACCAATTGACCTCAGACC
TTTCGACCATTAATAATAATTTCCACTGATAGAAAAAAAATTAATTTCCCCCAAATTTCTTTTTTTTTTT
TCACTATAGTGAGATCATAACTCCTTTGTCTAAACTCCTGACAAATTTTTAAGGGCAAAATGGACTATTA
CAGATGGAGAATCCCAAATCCAAAAATCCAAAATACAAAATGTGCCAATATCCAAAATTTTTTGACCACT
GGCATGATGTTCAAAGGAAATGCTCACTGGAGCATTTTGAAATTTTAGATTTTCAGATTTGGGATGCTAA
ACCGATACTTGTAATACAAATATTCCAAAATAAAAAATAATTAGAAATCCAAAACACTTTTGCTCTTATG
CATAAGAGATACTCAAACTCTATTAATTATAGACACCAAGCTGTACAGCAGATCTCTAGAACCTCCATAT
TTTGCATAATTGAAACTGCACACCCAAGGAACAACTCCCTGCCAGCCCTTGGAAATCACCACTCTGCTCT
TTTATTCTTTTTTCTTCTTTTTTTTTTTTTTTTTTTTTTTTAGATAGAGTTTTACTCTTGTCACCCAGGC
TGGAGTGCAATGGTGTGATCTTGGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGCAATTCTCCCTAGCC
TTCTTAAGTAGCTGGGATTACAGGCATGTGCCACCACACCTGGCTAATTTTTGTATTTTTAGTAGAGACG
GGGTTTCACCATGTTGGCCAGGCTGGTCTGGAACTCCCGACCTCAGGTGATCCGCCCGCCTCAGCATCCC
AAAAGGCTGGGATTACAGGCATGAGCCACCGCACCCGGTCTGCATTCTACTCTCTGATTCCATGAGTTTG
ACTACTCTAGGGACCTCGTATTCGTGGAACCGTACAGTAGTTGTCCTTGTACGACTGACTTCTTTCACTT
AACATAATCTCCAATGGGAGAAAATATTTGCAAAGATTCTTCCCAAATGTCTCTCTCATATCCATCAAAC
ACAGAGTCCATGAGGACCAGATTGCCAGCAGCTTCATGCTCCCTCTTTCCACCAGTCAGTTCTGCATTTG
CAAACGTTCATATGTATTTCTTATTAAGTTCCACGGAGTCCTCACCTGCCCTCTGCAGGAGGAGAAAACA
CATTAAGGACTGAGGACAGAGAACATGGTTCTGCTCCAAAGCCACCAGCTCCTGCATGTCCCCGCCCTCT
TTCTAAGTTGGGATTCTACTCTTCCTGTTGTTGTTGTTTGTTGTTGTTGTTGTTGTTGTTGTTTGTTGTT
TGTTGTTGTTACGGAGTCTTGCTCTGTCACTCAGGCTGGAGTGCAGTCGTGTAATCTCGGCTCACTACAA
CCTCTGCCTCCCAGGTTCAAGTGATTCTCCTTCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCATGCTC
CACCACACCCAGCTAATTTTTGTATTTTTAGTAGAGACTGGGTTTTTCGCCATGTTGGTCAGGCTGGTCT
CGAACTCCTGACCTCAGGTGATCTGCCCACCTCGGCCTCCCCAAGTGCTGGGATTACAGGTGTGAGCCAC
CGCACCCGGCCTTCTACTATACCTTTTACTGACTCACTGTCTCATGTCAGTCACCATGATATACCTGGAA
AGAATAACCTCACCTTGTAATTCTGAGACCTCAGCACCAGCATGTTCCAGGTGAGGACCCCAAGGTCAGC
CAGGCAGTCAGCCATCAGGGAAGGAACAGGAGAGGTGCCAGGGGATGTGACTCCTGGTCCTGTGTCTGTC
CAACACCCAATGCTGCTGCTTAATTCACAGTTGAGAAAGTCTCTTCTTCTTTCACAGGCAGGCAGCCTCA
CAGTCTCTGAGCCCTCAGACGGTCATGCATCTGTCTGTGACACACACATCTGTCTTCGTCTTTTTTTGTT
TGTGTGTTTGTTTGTTTGTTTGCTTGTTTGTTTTGAGAGACAGAGTCTCACTCTGTCGCCCAGGCTGGAG
TGCAGTGGTGCGATCTCGGCTCACTGCAAGCTCTGCCTCCCGGGTTCACACCATTCTCCTGCCTCAGCCT
CCCAAGTAGCTGGGACTACAGGCGCCTGCCACCATGCCTGGCTAATTTTTTGTATTTTTTAGTAGAGACG
GGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCGTGACCTCGTGATACGCCCGCCTCGGCCTCCCAA
AGTGCTGGGATTACAGGCGTGAGCCACCGCACCCGGCCTTGTCTTGGTCTTTTAAGGAGTGGAGTTGGCC
AAAGAATAGGAGATGTTGATTCTGATTAAAATATGCCTGTGGAGGAATCACAGGTGCCACACAGGGCAAT
CTTCTCTCTGTTTTCTGCACAGCGGAGCTGCCCAAGCCCTCCATCTCCAGCAACAACTCCAACCCCAAGG
AGGACAAGGATGCTGTGGCCTTCACCTGTGAACCTGAGATTCACAGCACAACCTGCCTGTAGTGGGTAAA
TGGTCAGAGCCTCCCGGTCAGTTCCAGGCTGCAGCTGTCCAATGACAAGAGGACCCTCACTCTACTCAGT
GTCACAAGGAATGACACAGGACCCTATGAGTGTGAAATACCGAACCCAGTGGGTGCCAGCTACAGTGACC
CAGTCACGCTGAATGTCCTCTGTATCTTCTGTTCCTCTGTGGCCCAGGCTTCCAGCCCAAATCCACACAG
CCAGAGGCCAGGCCTCTCAGTCCCTCTCAAGTCCAGGGACTCAGACTCTCACCCAGGCTGGCCATCACTT
CCTGTCCCAAGCAAACCTGGGCAGACCCAGCCTTGACCAAGAATAGGAGGGGAGAGGCTGCTCCTGTCCT
GGGAGGCTCAGGGTCCACAGCCTGTGATGGGAGAAACAGGTGAATATCTCAGACCCAGACTCAGTGGACA
GATTGGGTTTCGTTAGGACTTCAAGGTTGTGACTTGGCTCACAGGGACACTGTGGCTCTTCCACAGACCA
GGAGCTTCCCCTTCCCTTTGATGATATCATCTATGACTTTATTCTCGCTACTCCAGATGGACCGGGCATT
CCCACCATTTCCCCCCCAGACTCCTATTACCATCCAGGGGCAAATCTCAACCTCTCCTGCCACATGGCCT
CTAACCCACCTGCACAGTACTCCTGGTTTGTCAGTGGAATGCTCCAGCAACACACACAAAAGCTCTTTAT
CCCCAACATCGCAGTGGATAAGAGTGGATCCTATGCTTGCCTCGCCCATAACTCAGCCACTGGCCTCAGT
ACAATCACAGTCAAGACAATCACAGTCTCTGCTAAGTGGATCCCTGGAGCATAGGCCCTGAGCCCTGGGT
AAAGCCACTCAGTTTTCTGAAAGAGCCTAGAAGTTTATTTCCCAGCCCATGTCTTGGACACAAGCAAATC
CCAAACTCTACCCTGAGCCCTCTCACTCCACCTCTGCAGGACCCCTCCTCCCCTTGTTGTTCTGATTTCT
CACAGCTGACCTTGGGGCCAGCCTGGAATGTTGTACAAATTTTGTTTTATCACTTACGAGTTCTGTGACC
TTCCTTGACTTACTGAGGTGCTTTAAGTCTCAGATTCTAACTCTGCAGCTGGGGGTGATGCCCCCTCTCC
CTCAAGGTGATGTAAGGATGAGATGAGTTGTAGGTAGGTTGGTGCCCACTGGAACTGGCACATGGAAGGC
CCCTGAAAACAGTCAATGAACATCATCCCTGCTTATCAGCATTGAGTTGATGCCAAGGGCCTGCCCTTTG
TGAGTGTCATGGGATGGAAAAGGAGAAACAGAGGGAAGAGGCATGATGCGAGAGGAAGGAGGGACTAAAA
GGCACAGGAGCAGGGTGAGGTGCAGGCACCTCTGGGACAATGTATGAGTTGGTGCCGCCCAGTGTGTCAA
GCCTGCAGAAAATGGTGCCACCATGGAAAGCAAGGGAATCTGTGATGAGGACAACACAAGAGACTACACT
CAGGCCCCATGGCATCTCCTTCTTCCCTGACTGCACACCTTCCCTGCAAGGCCCCTGTGGTTTCCTCTGG
GATAGACTTGGGCCTCTATCCCCTTTGCCTTCTTCTTTCTGCAGAAGAAAATGCCCCAGGCCTTCCTGTG
GGGGCCGTCGCCGGCATCGTGACCGGGGTCCTGGTCGGAGTGGCGCTGGTGGCCGCGCTGGTGTGTTTCC
TGCTCCTTGCCAAAACTGGAAGGTACCACAGCTTTTTCCCATCCTTCTCCCACCCCCTAGGCTGACTCCA
GGCCAAAAGAAAGGAGACCTTGTCCTGTATTCAGGGCCAGGCTCTCCACGGCCTCCCAAGTCCCCAGGGA
TCCTTCCCTCTTATTCCACGGCTCCTCCCTCGTCAGCTCCTGACCCTGGGTTGCTGCCTCAACAGCTTCC
TCCTCTGTGAATTTGGCCCAATTAAGGCCCCACCCCTGAGTGTGGCCCTAGTTCCCTCACACAGCAAAGC
CACAGCTGCCTGGAGGGAGGGAGAGAAGGAGGGAGGGAAGTAGGGAGGGAGGGAGGGAGGGCGTGCTCTG
TACTTGGTACCTCCCATTGTTCATTGAATCCATCCACACAGTGAGGGGGATTTGCAGGCTCCGGATCCTG
GGCACCGTCACACAATGGGGAGTGGACCAGCCTGGACAGGCTGGGTGGGGTCAGTGCCCCCCATGGCTGA
TGTGGTAACCATAGGCCCTGAGGTGTGAGATGGGAGAACCTGGGCCTCAGAACAGCATGTCCTGGAGCGT
CCTTTGTGTCTCTTGCCAAGGGGTTGAGAGAGAGGACAAGGACACTGTCCCATTTCAGCATCACCAGCCC
TGAGTGCAGGGTCTGGCCACAGCAGGGACACTGAGTTCCAGGAGAATCCAAGACACTTGCGGTCCCCTCC
GTGTCCTGCACACGTGGCCCTGCTTTGCCTCTGGGGACTTGACCCTTCCTCTCAGGCAAACCCTCGTGGT
CTGTTTCCTTCCTTGGGTCCTCAGTCCCTTTCCTGGGTCCCTGGGTCAATGTTCTCCTGGCCCGGCATCT
GCCTGAGGGTCCTTCCCCTCTGCTCAGGACAGATGTGGGTTCCTAAAGCCTTTCCTCAACTCCCCTCTGC
TGGGCTCCCCCTAACACAAACCTGAGGGAGACAGGAGGTCTCCATGCCCATCCTTGAAAATGGGTTTCCC
TTCTTGTCCCCTGTTCGAACTCCAAAGTTGTGGCTTTTAACCTGGCACCCTCCCAAATGACCCTGACCTT
TCCTAGAACCAGCATCCAGCGTGACCTCAAGGAGCAGCAGCCCCAAGCCCTTGCCCCTGGTGAGTGTCCT
CTCAGCCCAGGTGTGGCTGGGAACCCCTAGGACAGCCCCACAGTGTCCGCTCCTGCCAGTCACTGCCAGG
CAGACTCTGATCCTTTCCCGGGGGCTGCAAGGAGGATCTCATAAAACATCACACAGGGGACCCCAATTGC
TTGGGTCAGCCCTCACCTGTGGGCTCTGGGTCATGGGTCACCTCCCCAACCTCAGCTGCTCAGGTATCTT
AGAGCTGAGGACCCCCTACGCCTTCCTGGAGAGGGGATAAGGCTCTCCTCCCACCCTGCTGCTCACTCCT
GTCTCTGTTTCCAGGCCGTGGTCCCTCCCACAGCTCTGCCTTCTCGGTAAGCCTGTCCCCTTCCAGCCCC
TTTCTACTGGGGTCCCAGCTGTGCAGGCTCTGGGCAGAGGGACCATCAGCCCCCCAGCACAGAACAGACC
CACCTTCCCCCAAAACACACAGGACAAGGCTAGCCCTGCCCTGGCCAGGAGCTGGGCCTCCCTACAGGGT
CAGGACCACCCACGCCCTGTGCTGACCCCTCCCCGGGACCCTCCATCACCTGAGGAGACCCCTGGAGTGC
AGCAGGTGCAGAGTGGACACTGGGACCATCAGTCAGGGGCCCACATTAACAAGGGTGCAGGGTGGGCCCA
GCCAGGAAAAGGGTCAGGGTGCTGTGTCCACACTGGGAGGCTGAGCTCAGGGGCAGAGCTGGTCACTCCT
GAGGGGAAATGACCAGAAGTAAACACAGAGAAGTAAATCCTGGCCAATCAGAGACAGGAAACTTCCAGGC
TGGGCCTCCATGACCCTCCCTCCCTGTCCACAGATGTCCCCTCTCTCCACTGCCCAGGCCCCCCTACCCA
ACCCCAGGACAGCAGCTTCCATCTATGAGGTGAGTGTGGGCCACGGATGTTCTGGTCCCACAGGCCCCAG
GGGACCCAGGATCTTCCCCTACTGGCATCGGCTGAGCTCTGAGATTCAGGAAACTGCTGTGAAAATAAGA
ACGGGGGTGGCGAGCAGAGGAGGGAGGGGCTTGGGAGCAGGAACCCCCTGAGCACAGCCAGGTTCAGCCC
CAGAGCAGCCCTGGATGGGCCCAGAGCCTGGGAGACGCCACACCCTGTTCTGAGGAGACTAGAGGGGTCC
AGGCCTCTTCTCTGTTTTAACAGGAATTGCTAAAACATGACACAAACATTTACTGCCGGATGGACCACAA
AGCAGAAGTGGCTTCTTAGCTTCCTCCAGGAGCTGCTCCTGTGTGTTGATGGAGAGTCCCCAAGGCCCCC
AGCCCTGGGGATGGGGAAGGACATGAAGCCTGAGCCAGAGAACCAGCTATAAGTCCTGAGAAGACACTGG
TGTCTGGGGGCAGGGAGGGATGGGGGTCCCTGATGAATATCTGGAGACCTCGACAGCCTGCCCTAGGCCC
TGGGTGGGTCAGGACAAAGGCCTCTCATCACCGCAGAAAGCGGGGGCTTGCAGGGAAAGTGAATGGGCCT
GTGGCCCACCTGGGGTCACTTGGAAAGGATCTGAATAAAGGGGACCCTTCCTCT
Protein Information
Protein Name transcript variant 3
NCBI Protein GI 461496471
Protein Accession NP_001264092
Protein pI 5.89
Protein Weight 20869.17
Protein Length 212
Protein Note Also known as CEA; CGM1; W264; W282; CD66D; MGC119875
Protein Sequence 
>NP_001264092.1 carcinoembryonic antigen-related cell adhesion molecule 3 isoform 2 precursor [Homo sapiens]
MGPPSASPHRECIPWQGLLLTASLLNFWNPPTTAKLTIESMPLSVAEGKEVLLLVHNLPQHLFGYSWYKG
ERVDGNSLIVGYVIGTQQATPGAAYSGRETIYTNASLLIQNVTQNDIGFYTLQVIKSDLVNEEATGQFHV
YQENAPGLPVGAVAGIVTGVLVGVALVAALVCFLLLAKTGRPWSLPQLCLLDVPSLHCPGPPTQPQDSSF
HL
Epitope Information
IEDB Linear Epitope