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SAG1

General Information
Protegen ID 326
Sequence Strain (Species/Organism) Toxoplasma gondii ME49
VO ID VO_0011000
Taxonomy ID 508771
Molecule Role Protective antigen
Molecule Role Annotation Oral immunization of mice with ZJ111/pcDNA3-SAG1 elicited specific humoral responses and stimulated proliferation of splenocytes (P<0.05). Mice immunized with ZJ111/pcDNA3-SAG1 displayed significant protection against an intraperitoneally challenge with 500 tachyzoite forms of T. gondii RH strain. Vaccination at 10(7) and 10(8)CFU per mice provided a 20% and 10% survival rate comparing 100% mortality of the non-immunized mice, exhibiting longer living time and better survival rate (Qu et al., 2008).
Related Vaccines(s) T. gondii DNA vaccine pVitro-SAG1-GRA7
References
Qu et al., 2008: Qu D, Wang S, Cai W, Du A. Protective effect of a DNA vaccine delivered in attenuated Salmonella typhimurium against Toxoplasma gondii infection in mice. Vaccine. 2008; 26(35); 4541-4548. [PubMed: 18590785].
Gene Information
Gene Name SAG1
NCBI Gene ID 7900172
Genbank Accession KE138836
Chromosome No X
Locus Tag TGME49_234370
Gene Starting Position 4326607
Gene Ending Position 4329557
DNA Sequence 
>NC_031478.1:4326607-4329557 Toxoplasma gondii ME49 chromosome X, whole genome shotgun sequence
AGACTGGCATTGCGACCCGACCAGTAGCAAGCTCTGCTCGAGAGGCAATTTGTAGAGATGTTTTGAGCAG
TTTGATGGTGTGTGAGAAGAGGACACGGTTGGGGTCCTCTGTCATTCGAGAACACGATCCAGCCCTTAGA
AAGCATGACTTATGTCGGCGGCGCCCCCTTTCCTCGGGTACCTGTTTTGTCCCCAGGATGAGCAAGCACC
GCTTGTTACACTCGGCAGATTTGAAGTGGGCAGTCACGAGAAAACTGATGTGGCCAGTACGCTCCACCAT
GTTACTGCACTCTCATCACCCGCGATTCTCTGCAAGAACAGATTCAGAGGGTCCCACAATTCCCTATTCC
ACGACACACTCTCGCAGCAGTGCCACAAGCACAAAAGGGTTTGTTTCGACGCATGAAATAGACCGCCCCT
CCAGAGAAAACCTGTATTGGTGCAGCCATTCAAAGCATAGCGGGGCATGATCAACGACTGCCTGCTGCAT
TTTCGGAGTTGGGGCTCTTCAAAACAAACGACGTGAGATGGCTTTGCCACAAGATAGTGCTAAATGCCTG
TTTTTCCATACGAGGTTCGTTACACCGACTTCGGTGTCGCCCTGCAAAATGCTGACCGCTTCCCGCATTG
TCTATGATCCTGCCAGAATGGAGTCACCCTCATGCCCCCACTTCCCCTCGCGAGTGACAGGGCAGCTCGA
GGTTTGACATGAATGGCAGAAGAGTTCACTTTCCGAACGCCCACTCAAGATTACGCCATCCATCTGCCAC
AAAATATTACGCGCCTCCGCTTCCACTGAAGTGCTGCTTGCGGTGTCGCCTAAGCCCTGAAGTTTGCGTT
TTCTGGTGCTTCTTCTGTCACGAGGGTGATGATGTAAGACTGGTCCTTTGCCTTTGAGTCCTCTATCGCC
TCGCATCTGAACGAGAATGTTTTTGAAACAGGGACATTTTCCGGCACGTTGAGTACAGCAGGTTCTTTTA
TGCCGTCACCCCCCGTCCACCATTGGTGCGAGTCCGGCACACCAGGAAAGAGGGCTTGGAGAGTCTTCTT
ACTCGTGCAACTACTGCCTTTTCCCTCACAAACCAGCTTTTTGAAGTCTTCAGGGACCCAGTTCTTGGCA
TTGTTGCATTCGATCGCCACCTTCCATCCAGGATACACATAAGCGATGTTCTCAGTGCCCGTCCCGCGGA
TGGAACTGAACCACACGATGTTGTACTGTCCAAACGGAAACTGCTGCTCCTTTCGTGCATTCTTGAAAAA
CTTTGGGGCGGTAGCTTGGTCTGCGTCCATTGCAGAGGCATAGGCAAATATGGAAAGAAGCATTGCTACC
GAAGCGAGCTTCATTTTGTCAAGCAGAGCCAGGAAGCCTGGAACAATGAGGTTGGCCAGAGAAGACAACC
TACTGACGTTGGTAGAGAGAGCTCAACAACACTACTGCATGCAAGAAAAAGATGCACGTTCCTCCCACTC
AAACATCACTGGAACTTTTGTAATGCCAGGCAGCAGACTCACAAGAATCGATGTTGGTGCCCCGTGCAGG
GAAAGATCAGTCACCCGCGTATGCGGGTAGGTTGGCTACTAAGACAGCGAAGACGAATGCCCATGAGAGT
GGATTTTCCCGGACTCAAGGACAGCGGCTTGTCTGAAACGAGGCACATGAAAGAACAAAATTCGACGGCA
ACTGTGCGTGTCCGGAGAGTCAGCAAAAAGTTCGACTCTCCAGCGTATACCTGCATTACCCTGCGCTCTT
GGTCACCTCGGCTAGCCGCCTTTCTGCTTCGTGTGTGGCTCTCCCCGTTCTTGTGCCGCTGCAGTCGTTG
ATCCAGAGAGGTGTCACCTGTGCTTCAGCGCGGGGGTGTACACTTGGTGTGAGTTTGGAAGCCTTACGTA
AAAGTGGGGTCCAAAGTGCATTGATCCATGGATTACCAAACGAGTCGTAAAACCCCCGTCTTTGCCGTGC
GTTCCCCGTCCGCGCGTTTTAGATTCGATGCTTCTCCGCGGAGTACGGAAACAAAACGAGCTTTACAAAA
CTTTGGGCACTACTCCGGCATCCTTTGCGGCGATTCGTCTCCTTCCACTGAACGCTGCTGTAACTAATGG
CGCGGTTACTGCCTGCAGAGAAATACCAGCGACACACTCCCGTTCGCTTTTGAGGCGCCCTGCGAGTTCA
TTACCTCTACCGGGCGGGCACTATGGTATCGTCACGCGTCACGGTGCAGTCGGCGTGATGTCACCACACG
CTGCCAGTGGATATATCTACGGAAGCTGTAAGTAGGGCAAGCGTTGTCACCTCTGTGCACTTCATCAAGC
ACTCCGAATGAGAGCTTGCACCTAATTCCTCAATACGTAGGCAGAGGCGATGGAACCGTGTGTGTGCATA
TACTGCCCCAGAGGGCGTGCGTGGAAGTCGGCGGTCCACCACGGGGCGGTCAGTCGTGTGCGTCGTGGAT
TCACTTTTGCACAGTTCCGCGAGACTCCTGCAGAAGCAAAAAGTTAATTAAACATTGTTGTTCGTTAATA
ATCTCCGCGCCTGAACAAGGGCATTTAGCGGGCACGACCAGACAAACTGCTCTTTAGCTGCAGTTCTTAG
TGCCACCTTCACATTGCAGGATGGAAAAGAAACTAGACTCCGGGTAAAAGTAGAAGGATACAGGGATTCC
CACAAAAAATTGAACTGTGCAAGGAATTGGTGTTTTATAGATGAAGCACGGACCAGAAAAACAGTTCGCC
TCTCGTTACTCTAAACCGTAGCGTTGCATCGCCAAGCGGGGCGGCACGGTCTGAACTTGTCTACTCCAGT
CGACCTTAGTGCTGCAGAGACATGTTATCTGCGGCTCCGCTGGCGTGCGTTGACATTTGCCAGAAAGTCT
AAAGAGTTACTACACCATACAGCTTCGCAGAAATCCGCAACAGACGGGTGTCTTCGCTCTGGGAATGCAG
GACAGTTGTCC
Protein Information
Protein Name surface antigen SAG1
NCBI Protein GI 237839159
Protein Accession XP_002368877
3D structure: PDB ID 1KZQ
Protein pI 7.13
Protein Weight 18124
Protein Length 174
Protein Sequence 
>XP_002368877.1 SAG-related sequence SRS42 [Toxoplasma gondii ME49]
MKLASVAMLLSIFAYASAMDADQATAPKFFKNARKEQQFPFGQYNIVWFSSIRGTGTENIAYVYPGWKVA
IECNNAKNWVPEDFKKLVCEGKGSSCTSKKTLQALFPGVPDSHQWWTGGDGIKEPAVLNVPENVPVSKTF
SFRCEAIEDSKAKDQSYIITLVTEEAPENANFRA
Epitope Information
IEDB Linear Epitope