VIOLIN: Vaccine Investigation and Online Information Network

YopD from Y. pestis KIM 10

General Information

Protegen ID

339

Sequence Strain (Species/Organism)

Yersinia pestis

VO ID

VO_0011002

Taxonomy ID

632

Molecule Role

Protective antigen

Molecule Role Annotation

Modified yopD antigens were able to partially protect immunized mice at various levels against lethal challenge with Y. pestis KIM 1001 strain (Wang et al., 2008).

References

Wang et al., 2008: Wang S, Joshi S, Mboudjeka I, Liu F, Ling T, Goguen JD, Lu S. Relative immunogenicity and protection potential of candidate Yersinia Pestis antigens against lethal mucosal plague challenge in Balb/C mice. Vaccine. 2008; 26(13); 1664-1674. [PubMed: 18291562].

Gene Information

Gene Name

YopD from Y. pestis KIM 10

NCBI Gene ID

1149313

Genbank Accession

AF053946

Locus Tag

D744_p5050

Plasmid No

pCD1

Gene Starting Position

40619

Gene Ending Position

41539

DNA Sequence

>NC_004839.1:40619-41539 Yersinia pestis strain KIM5 plasmid pCD1, complete sequence
CATGACAATAAATATCAAGACAGACAGCCCAATTATCACGACCGGTTCACAGCTTGATGCCATCACTACA
GAGACAGTCAAGCAAAGCGGTGAGATTAAAAAAACAGAAGACACCCGTCATGAAGCACAAGCAATAAAGA
GTAGCGAGGCAAGCTTATCTCGGTCACAGGTGCCAGAATTGATCAAACCGAGCCAGGGAATCAATGTTGC
ATTACTGAGTAAAAGCCAGGGTGATCTTAATGGTACTTTAAGTATCTTGTTGTTGCTGTTGGAACTGGCA
CGTAAAGCGCGAGAAATGGGTTTGCAACAAAGGGATATAGAAAATAAAGCTACTATTACTGCCCAAAAGG
AGCAGGTAGCGGAGATGGTCAGCGGTGCAAAACTGATGATCGCCATGGCGGTGGTGTCTGGCATCATGGC
TGCTACTTCTACGGTTGCTAGTGCTTTTTCTATAGCGAAAGAGGTGAAAATAGTTAAACAGGAACAAATT
CTAAACAGTAATATTGCTGGCCGCGAACAACTTATTGATACAAAAATGCAGCAAATGAGTAACATTGGTG
ATAAAGCGGTAAGCAGAGAGGATATCGGGAGAATATGGAAACCAGAGCAGGTAGCGGATCAAAATAAGCT
GGCATTATTGGATAAAGAATTCAGAATGACCGACTCAAAAGCCAATGCGTTTAATGCCGCAACGCAGCCG
TTAGGACAAATGGCAAACAGTGCGATTCAAGTTCATCAAGGGTATTCTCAAGCCGAGGTCAAAGAGAAAG
AAGTCAATGCAAGTATTGCTGCCAACGAGAAGCAAAAAGCCGAAGAGGCGATGAACTATAATGATAACTT
TATGAAAGATGTCCTGCGCTTGATTGAACAATATGTTAGCAGTCATACTCACGCCATGAAAGCCGCTTTT
GGTGTTGTCTG

Protein Information

Protein Name

Yop targeting negative regulator

NCBI Protein GI

31795494

Protein Accession

NP_857949

Protein pI

6.98

Protein Weight

31501.57

Protein Length

306

Protein Note

Yop targeting negative regulator; translocon component; important for translocation pore formation

Protein Sequence

>NP_857949.1 Yop targeting negative regulator (plasmid) [Yersinia pestis]
MTINIKTDSPIITTGSQLDAITTETVKQSGEIKKTEDTRHEAQAIKSSEASLSRSQVPELIKPSQGINVA
LLSKSQGDLNGTLSILLLLLELARKAREMGLQQRDIENKATITAQKEQVAEMVSGAKLMIAMAVVSGIMA
ATSTVASAFSIAKEVKIVKQEQILNSNIAGREQLIDTKMQQMSNIGDKAVSREDIGRIWKPEQVADQNKL
ALLDKEFRMTDSKANAFNAATQPLGQMANSAIQVHQGYSQAEVKEKEVNASIAANEKQKAEEAMNYNDNF
MKDVLRLIEQYVSSHTHAMKAAFGVV

Epitope Information

IEDB Linear Epitope