VIOLIN: Vaccine Investigation and Online Information Network

YopO

General Information

Protegen ID

340

Sequence Strain (Species/Organism)

Yersinia pestis Angola

VO ID

VO_0011003

Taxonomy ID

349746

Molecule Role

Protective antigen

Molecule Role Annotation

Modified yopO antigens were able to partially protect immunized mice at various levels against lethal challenge with Y. pestis KIM 1001 strain (Wang et al., 2008).

COG

COG0515RTKL, under R: General function prediction only; T: Signal transduction mechanisms; K: Transcription; L: Replication, recombination and repair

References

Wang et al., 2008: Wang S, Joshi S, Mboudjeka I, Liu F, Ling T, Goguen JD, Lu S. Relative immunogenicity and protection potential of candidate Yersinia Pestis antigens against lethal mucosal plague challenge in Balb/C mice. Vaccine. 2008; 26(13); 1664-1674. [PubMed: 18291562].

Gene Information

Gene Name

YopO

NCBI Gene ID

5798322

Genbank Accession

CP000902

Locus Tag

YpAngola_B0072

Plasmid No

new_pCD

Gene Starting Position

49111

Gene Ending Position

51300

DNA Sequence

>NC_010157.1:49111-51300 Yersinia pestis Angola plasmid new_pCD, complete sequence
GTCACATCCATTCCCGCTCCAACCGGTTCAGTCGCTCGGCGATGGTCGTCAGCTCTCGCAACTTTTCTCT
CTGTTCAACCAAATGCTCATCCATTAAACTGCTTCGTCCAAGTTGAATCAGTAGTGGAATAGAGTCCACT
GTAAAGTTTCGCATATCATCAGTAAACTCCGATACCTCCTGTAGCGTAATAGCTGCATGGGCCGCCATCA
TCTGACGGTGAATTGCGGTATACTGCTCAGTGCCGAATTTCACTACAGGCCGGGTACTGTCAAAACGCTG
CAGGGACTGACGAGCAACATCGGCCCAAGAACCTGAACGATTAATCAGAATAGATAATTGCGCTTTCGCA
CTCTCCTGCTGCTGCTGGAGAGTATTCAATTGCTGCGACAAGGTGATCTTAGCCTCAGTTAATCGATTCA
GGAAGCCGTAGGTTTCAGAGGACACGGGCTGCCCTTGCTGTGACAAGGTGACTAAGACCTCTAAAAGCGT
TTCCAGGTGCTTATGTGCGCGCACTAGTGAACCGATATCAGAAAAAGAGTGTGTCTGGTCCAGATGCTTC
TGGATCCTCTGCAGTGAAGGTTCGACGATCGATAGCATAAAGTTACTGCGATGATAGGGGGATACTTCCG
TACTGGAATTCTTGGTATCCCCTTCTCTGCCTTTGACATAGTCTTCAATCACTCTGTAAGTCTTCAGAAT
CAAACTGTTAAAACTCTTCAACTGATCCTTGTCTACTCCCCCCTCGCGTTCGGCCTTGTCGAGTGCCACC
AACATGGTATCAAGATCCGACAAAACCCCCCCCATATCCAATTGCTTAGTTGCTGCACTGCTCAAATGCG
TCCTAAGCAAATCAGATAGCTCCCGAAGCTTCTTGGGTGTTATCCGCCTTACATCAGTAGATAATGGGCT
CATTTCTCCGGTTAGGGTATCTTTTAGGATCTGCTTGGCCGACTCCTCGTCGATAGTTCCGTCGCTCAAG
AACTCGTGGAGTCTGGCTTCGTTGGAATCAGGTCTTGAGTCAGCGGAAACGCCAAGGATGTCTGTGATGA
AGCGTGTATAGGCTGTCTCGACTCCAGCTATACCAGGTCGATGGATTGGATAACCATTCTCATCCATTAC
GTGCGCTGGTTCTGAGGTAATGAATCTCAGTCCTTGATTAGGCTTTATCTCCGGATTTTTCTCAAAACCT
TCGATACAATGTAGAAGGGTTGACACTACGAGAAAAACATCGCTCTTTTCTGATGCGCCTAGGTTTCCTA
CTCCAAGCTCCGGCGCTTTGAAGGATTCTGTAAACCCCTTAGGTTGTTCCCCTGAACGAGAGTGTAATCC
TAGATCAATAACAACGGGCTCTCCGCTAGCGCGGTCAAATACCACATTACCGGGTTTGATATCGTTATGT
ACTACCCCTGCCTTGGCAAGGTGATTGGTTACATCTAATAGCCGATGGGCAATAAACTTGATCGTTCCCC
AGTAGGCTTCACTATTGATCTTTCCTTGCTTCCAGCTATCGGCGAGGGTTCTTAGTGTGTCAGAACAACG
CCAACCATCCACCTCATCCATCAGCAATGCTTCCTCCTTACGGTTACCGTATGGCACCACAGCCATGCCA
TGAACATTGGCAAGATTAGGATGTTTGCCCGCGGTTTTATAGATGTGTTTATAAGCCTCCAGTTCTGCGA
ACAAATGCCCCTCGGCAATGGAGCGTTCAATCTTAGCTACCAACCGCTGCTTATCCTTAGTTTCTATTAT
ACTAATATGGCTTTCGCCCTCGGCAAACTTATCGGTTTCAGCCACTCGCATCCCTTCAAGATCCGGAGCT
CCTGATAAGGGCTCCCCTTTCCAACCCAGCGGCAGTTCGGTCTGTGGCTTGGCTCCAAAGAGATTACTGA
GAGCATTGGGGATATCAGACCTTAGCTCCTGCGAAGTCGTTTTCTGGGCCGCATGGAGTGTGTCAGTAAG
GTTACGAGCAATTGAAAAGTTAAACATCTTCCCCGAAAAGATCTTACCAACCCCTTCTCGAAAGAGAGAA
AAACCACTGTGGGGGTTCAAGCGCAACACTTGATTATCGATAATTCTATACCGTTTTCCTCCGATATTGA
GCTCACCGACAGGATTTTGCCAATGTTGGCTGATGCGCTCATGAGCTTTGGCGAGGGAGATCGACGGTGG
CATAGTTCCCATGATTTTCA

Protein Information

Protein Name

protein kinase YopO

NCBI Protein GI

162417777

Protein Accession

YP_001604502

Protein pI

6.71

Protein Weight

77377.02

Protein Length

729

Protein Note

alternate gene symbol ypkA; identified by similarity to SP:Q9RI12; match to protein family HMM PF00069

Protein Sequence

>YP_001604502.1 protein kinase YopO (plasmid) [Yersinia pestis Angola]
MKIMGTMPPSISLAKAHERISQHWQNPVGELNIGGKRYRIIDNQVLRLNPHSGFSLFREGVGKIFSGKMF
NFSIARNLTDTLHAAQKTTSQELRSDIPNALSNLFGAKPQTELPLGWKGEPLSGAPDLEGMRVAETDKFA
EGESHISIIETKDKQRLVAKIERSIAEGHLFAELEAYKHIYKTAGKHPNLANVHGMAVVPYGNRKEEALL
MDEVDGWRCSDTLRTLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAKAGVVHNDIKPGNVVFDRASG
EPVVIDLGLHSRSGEQPKGFTESFKAPELGVGNLGASEKSDVFLVVSTLLHCIEGFEKNPEIKPNQGLRF
ITSEPAHVMDENGYPIHRPGIAGVETAYTRFITDILGVSADSRPDSNEARLHEFLSDGTIDEESAKQILK
DTLTGEMSPLSTDVRRITPKKLRELSDLLRTHLSSAATKQLDMGGVLSDLDTMLVALDKAEREGGVDKDQ
LKSFNSLILKTYRVIEDYVKGREGDTKNSSTEVSPYHRSNFMLSIVEPSLQRIQKHLDQTHSFSDIGSLV
RAHKHLETLLEVLVTLSQQGQPVSSETYGFLNRLTEAKITLSQQLNTLQQQQESAKAQLSILINRSGSWA
DVARQSLQRFDSTRPVVKFGTEQYTAIHRQMMAAHAAITLQEVSEFTDDMRNFTVDSIPLLIQLGRSSLM
DEHLVEQREKLRELTTIAERLNRLEREWM

Epitope Information

IEDB Linear Epitope