VIOLIN: Vaccine Investigation and Online Information Network

HtpG

General Information

Protegen ID

345

Sequence Strain (Species/Organism)

Yersinia pestis CO92

VO ID

VO_0011008

Taxonomy ID

214092

Molecule Role

Protective antigen

Molecule Role Annotation

Using a mouse plague model, YPO3119 (htpG) may provide partial protection against challenge with a low dose (20 times the 50% lethal dose [20x LD(50)]) of Y. pestis (Li et al., 2009).

References

Li et al., 2009: Li B, Zhou L, Guo J, Wang X, Ni B, Ke Y, Zhu Z, Guo Z, Yang R. High-throughput identification of new protective antigens from a Yersinia pestis live vaccine by enzyme-linked immunospot assay. Infection and immunity. 2009; 77(10); 4356-4361. [PubMed: 19651863].

Gene Information

Gene Name

HtpG

NCBI Gene ID

1175934

Genbank Accession

AL590842

Locus Tag

YPO3119

Gene Starting Position

3475893

Gene Ending Position

3477767

DNA Sequence

>NC_003143.1:3475893-3477767 Yersinia pestis CO92 chromosome, complete genome
ATTAAGCCGTGAGTAACTGATTCATTCGACGAATAAACTGGTTAGGGTCTTCCAATGTTCCCCTCTCCGC
GAGCAGCGCCTGATCCAGTAATAACTCAACCCATTGTGCAAATTGAGTGTCATCTGTAACTTCCGCAGCA
CGCTTAACCAAGCCATGATCTGGGTTCAGTTCAAAGATGTACTTCACTTCCGGAGCCTGTTGACCCGCGG
CCGCGAATAGCTTAGCCATCTGCGTACTCATTTCATCCGCATCAGTCGTTACGATTGCGGGTGTATCCGT
TAGGCGATGTGTCAAGCGCACGTCTTTAACACGCTCACCCAATAACGTTTTCACGCGTTCAACGAAGGGC
TCCAGTGCTTTCTCTGCTTCTTGCTGCTCTGGATTTTCTTCATCAGCCAATTTATTCAGTGAGTCATCTG
CTTTACTGACCGATTGGAACGCTTTACCTTCGAACTCAGTCAGGTAGCTCATCATCCATTCGTCGATACG
ATCGGATAACAATAGGACCTCGATACCTTTTTTACGGAACAGTTCCAGATGCGGGCTACTCTTCGCAGCA
GCATAGCTGTCAGCAGTGATGTAATAAATTTTCTCCTGCCCTTCTGCCATACGGCTGACATAGTCTTCCA
GTGACACGGTCTGTGCGGAACTGTCGGTATGCGTTGAAGCAAAGCGCAATAGCTTAGCGATAGTCTCTTT
ATTGCTACCATCTTCCGCTGGGCCTTCTTTTAATGCCATGCCGAATTGTTGCCAGAATTGCTGATATTTC
TCAGCATCATCTTTAGCCAGTTTTTCCAGCATTTGCAGCACACGCTTAGTCAATGCACTGCGCAGATTCT
GTGTAATACGACTGTCTTGTAAAATCTCACGGGAGACGTTCAGCGGCAGATCGTTCGAATCTATCAAACC
ACGGACAAACCGCAGATAGTTCGGCATAAACTGCTCAGCTTCATCCATGATAAACACACGCTGCACATAA
AGTTTTAAACCATGTTTGTGATCACGGTTCCACATATCCCATGGTGCCTGCGCGGGGATATACAGCAAGC
TGGTGTATTCCTGCTTCCCTTCAACGCGGTTGTGACTCCAACTGAGTGGATCGGTAAAATCATGGGCAAT
ATGTTTGTAAAATGCTTTGTATTCGTCGTCAGAGATTTCTGCTTTACCACGGGTCCACAGCGCCTGAGCT
TTGTTGATTTTTTCCCAGGTGACAGTGCCGTCTTCTTCATTTTTAACCTGAATTTCAACCGGCAGTGCAA
TATGATCTGAGTATTTGCTGATAACAGAACGTAGACGCCAGTCATCCAGATACTCGTCTTCGCCTTCACG
CAAATGTAGCGTAATTTCAGTACCACGCTCGTCTTTAGTTATATCGGCGATGGTGTAATCACCTTCACCA
GCAGATTCCCAGAATACACCGGTATCGGCAGGGGCACCGGCAGCTCGGGTACGTACGGTAACTTTATCGG
CAACAATAAATGCTGAGTAGAAACCCACACCAAATTGACCGATTAATTGGCTGTCTTTGGCCTGATCAGA
ACCGATTGATTCAAGAAATGCTTTAGTCCCTGATTTGGCGATAGTACCAAGATTATCAATGACTTCGTCA
CGGGTCATACCGATGCCGTTATCACTCAGGGTTAAAGTACGTTTCTCTTTATCAAAAGATAAACGCACTC
TCAGTTCGCCATCCCCTTCAAAGAGTTCGGGGTTAGACAGGGCACGGAAACGGAGTTTATCTGCAGCATC
AGAAGCATTGGAGATCAGCTCGCGCAGAAAAATTTCTTTATTGGAATAAAGCGAGTGAATCATCAAATGG
AGGAGCTGTTTTACTTCAGACTGGAATCCACGGGTTTCTTGACCTTTCATATTCA

Protein Information

Protein Name

heat shock protein 90

NCBI Protein GI

218930152

Protein Accession

YP_002348027

Protein pI

4.79

Protein Weight

67953.62

Protein Length

624

Protein Note

molecular chaperone

Protein Sequence

>YP_002348027.1 heat shock protein 90 [Yersinia pestis CO92]
MNMKGQETRGFQSEVKQLLHLMIHSLYSNKEIFLRELISNASDAADKLRFRALSNPELFEGDGELRVRLS
FDKEKRTLTLSDNGIGMTRDEVIDNLGTIAKSGTKAFLESIGSDQAKDSQLIGQFGVGFYSAFIVADKVT
VRTRAAGAPADTGVFWESAGEGDYTIADITKDERGTEITLHLREGEDEYLDDWRLRSVISKYSDHIALPV
EIQVKNEEDGTVTWEKINKAQALWTRGKAEISDDEYKAFYKHIAHDFTDPLSWSHNRVEGKQEYTSLLYI
PAQAPWDMWNRDHKHGLKLYVQRVFIMDEAEQFMPNYLRFVRGLIDSNDLPLNVSREILQDSRITQNLRS
ALTKRVLQMLEKLAKDDAEKYQQFWQQFGMALKEGPAEDGSNKETIAKLLRFASTHTDSSAQTVSLEDYV
SRMAEGQEKIYYITADSYAAAKSSPHLELFRKKGIEVLLLSDRIDEWMMSYLTEFEGKAFQSVSKADDSL
NKLADEENPEQQEAEKALEPFVERVKTLLGERVKDVRLTHRLTDTPAIVTTDADEMSTQMAKLFAAAGQQ
APEVKYIFELNPDHGLVKRAAEVTDDTQFAQWVELLLDQALLAERGTLEDPNQFIRRMNQLLTA

Epitope Information

IEDB Linear Epitope