VIOLIN: Vaccine Investigation and Online Information Network

YdeN

General Information

Protegen ID

346

Sequence Strain (Species/Organism)

Yersinia pestis CO92

VO ID

VO_0011009

Taxonomy ID

214092

Molecule Role

Protective antigen

Molecule Role Annotation

Using a mouse plague model, YPO3047 (ydeN) may provide partial protection against challenge with a low dose (20 times the 50% lethal dose [20x LD(50)]) of Y. pestis (Li et al., 2009).

References

Li et al., 2009: Li B, Zhou L, Guo J, Wang X, Ni B, Ke Y, Zhu Z, Guo Z, Yang R. High-throughput identification of new protective antigens from a Yersinia pestis live vaccine by enzyme-linked immunospot assay. Infection and immunity. 2009; 77(10); 4356-4361. [PubMed: 19651863].

Gene Information

Gene Name

YdeN

NCBI Gene ID

1175868

Genbank Accession

AL590842

Locus Tag

YPO3047

Gene Starting Position

3403234

Gene Ending Position

3404907

DNA Sequence

>NC_003143.1:3403234-3404907 Yersinia pestis CO92 chromosome, complete genome
CTTAATTCATACCAAGCGATTGCTTAATTTTATTAAATTTATCCTGATTAACTTCACTAACAGGAGATTG
ACTCTGATTAATGAAGTTCCTCATCTCGGCTTGCATTACCTTAACAACATCAGGATGGGTACTTGCAAGG
TCTTGTTTTTGATTTAAATCACTCAGTTTATACAGATTTAACTTATTACCTTCATAGGTATAGGTTAAAG
AGTAGTCATTACTGCGGATGGTATAAGAGAATTGACTAAGATCTTCGGTATTTGGGTTTTTAGGATATTC
ATTGGATTCATTACGCACAAATTTATGGTAACCATCCCAGAATGGAATATTCTCTTCATCGAACCAGTGG
GTATAGGATGTCACCCAGGTAAGATATTTATGCGGTTCAGCTTTGCTTTTCCCCGTCAAATAAGGAAGCA
GTGAGACACCATCTAAATTATTTGGAGCATCAATCTCAGCGGCTTCAAGCGCTGTAGGCATGAAATCCAT
TGCAGAGATCAACTTGTCATAATTTCCTGTTTGCAATTTCCCCTTCCACCAAATAAACATTGGAGTATGG
GTTCCGCCAGGAAATGTTTGGCTTTTATACCCTTTCTGATTACCGTTCAACGGTAATGGCCCATCGATAA
CGGCACCGTTATCAGAGGTAAACATAATTATCGTATTGTCATATTGACCATTCTTTTTAAGCTGCTCAAG
AAGCCGTTTTACGCCCTGGTCAACAGAATAGACAGAGGCATAGAAGTTATCAGCAGTTTGGCTACCTGTA
TTAAAGTGTTTCTGATATTCATCCGGCGCTGGATTATCATTAGGTAAATGGGGAGCACTGTAAGCCAAAT
ACATCATGAATGGCTCATCTAAGGATTTAGCTCTATTGGCAACACCGATAGCCTCATCGGTAAGTTGATC
ACTGATATAACCTTTGGCTTTCACCCGCTCTTTATTATGGAAAAGAGACGGGGAATTATAATAAGCCGTT
CCCGCGGCATGGTAACCCATAAAATACTGGAAGCCTCGGTTTTGAGGCTGCCATTCATCGGCTGAGTAAG
TTGTAAAGTTATCGTGGTAATCGCGCGTTTGCTCCGCTTCAGGAACAGGAACATTACTGATTTTTGAAAG
ATGCCATTTTCCGATGGCCGCCGTGTAATAGCCATTGTTTTGCAATAACTCAGGCAGGAATGTCTCTTCT
AATGAAATCCCATTCTGAGCATCGGTATTGGAGTAAACACCAAACCTTGCAGGGGACCGGCCCGTCATAA
TGGCCGCCCGCGAAGGCCCTGATACGCCATGAGCAACGTAGCCATTCGTCAGACGAACCCCTTCATCCAT
CAACGAGAGTAGTGTTGGCGTGGACTTTTTGGCGGCTTCAATGGCTTTATCAATGCCTATTTTGTAGGTA
TCAACAACGTCCCGATCTTCCATCGACTTAGGGTCAAAGGAGGTCTTATCAAAAGGGAGCTGCCCATAAC
CTAAGTCATCCATGGTTAAGACAATGATATTTGGCTTATTCTTCGTGCTGTATTCTTTTGGCGTAAAATC
AGCGAAAGCAACATTGGTGTTTGTTGCTTTGAGTTTGACATCATCAGCATATGCAGGGCCACCCATGACG
CCCGCAGCTAAGATGACCGATATCGAAGCACTAATAATGCTCCTGTTAACCTTTAAATTCATCA

Protein Information

Protein Name

sulfatase

NCBI Protein GI

218930092

Protein Accession

YP_002347967

Protein pI

5.8

Protein Weight

59706.08

Protein Length

557

Protein Note

Similar to Escherichia coli putative sulfatase YdeN precursor SW:YDEN_ECOLI (P77318) (560 aa) fasta scores: E(): 0, 80.0% id in 556 aa

Protein Sequence

>YP_002347967.1 sulfatase [Yersinia pestis CO92]
MMNLKVNRSIISASISVILAAGVMGGPAYADDVKLKATNTNVAFADFTPKEYSTKNKPNIIVLTMDDLGY
GQLPFDKTSFDPKSMEDRDVVDTYKIGIDKAIEAAKKSTPTLLSLMDEGVRLTNGYVAHGVSGPSRAAIM
TGRSPARFGVYSNTDAQNGISLEETFLPELLQNNGYYTAAIGKWHLSKISNVPVPEAEQTRDYHDNFTTY
SADEWQPQNRGFQYFMGYHAAGTAYYNSPSLFHNKERVKAKGYISDQLTDEAIGVANRAKSLDEPFMMYL
AYSAPHLPNDNPAPDEYQKHFNTGSQTADNFYASVYSVDQGVKRLLEQLKKNGQYDNTIIMFTSDNGAVI
DGPLPLNGNQKGYKSQTFPGGTHTPMFIWWKGKLQTGNYDKLISAMDFMPTALEAAEIDAPNNLDGVSLL
PYLTGKSKAEPHKYLTWVTSYTHWFDEENIPFWDGYHKFVRNESNEYPKNPNTEDLSQFSYTIRSNDYSL
TYTYEGNKLNLYKLSDLNQKQDLASTHPDVVKVMQAEMRNFINQSQSPVSEVNQDKFNKIKQSLGMN

Epitope Information

IEDB Linear Epitope