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LolA

General Information
Protegen ID 347
Sequence Strain (Species/Organism) Yersinia pestis CO92
VO ID VO_0011010
Taxonomy ID 214092
Molecule Role Protective antigen
Molecule Role Annotation Using a mouse plague model, YPO1377 (lolA) may provide partial protection against challenge with a low dose (20 times the 50% lethal dose [20x LD(50)]) of Y. pestis (Li et al., 2009).
References
Li et al., 2009: Li B, Zhou L, Guo J, Wang X, Ni B, Ke Y, Zhu Z, Guo Z, Yang R. High-throughput identification of new protective antigens from a Yersinia pestis live vaccine by enzyme-linked immunospot assay. Infection and immunity. 2009; 77(10); 4356-4361. [PubMed: 19651863].
Gene Information
Gene Name LolA
NCBI Gene ID 1174218
Genbank Accession CP009973
Locus Tag YPO1377
Gene Starting Position 1550480
Gene Ending Position 1551088
DNA Sequence 
>NC_003143.1:1550480-1551088 Yersinia pestis CO92 chromosome, complete genome
AATGAAAAGACTGCTTGTTGCTTGCTGTTTTCTATCGGGTTTGATTTCAGCTTCTGCGTTGGCAGATGCC
AGCACAGATCTACAAAATCGGTTGAGTAAAGTGAATAGCTTCCATGCCAGCTTCTCGCAAGCTGTTACCA
GTTCAGACGGGGCGGTAGTGCAGGAAGGTGAGGGCGAACTGTGGGTAAAACGTCCTAATTTGTTTAACTG
GCATATGACATCACCGGATGAAAGCGTATTAATCTCTGATGGGGAAACTCTGTGGTTTTATAACCCATTT
GTTGAACAAGCCACCGCCACTTGGTTGAAGAATGCAACGGGTAATACACCGTTTATGTTGATTACTCGCA
ACAACCCAGATGACTGGAAGCAATATAATGTTAAGCAGAAAGGCGATGATTTTGAGCTGACACCTAAAAG
TGCTAGCGGCAATTTAAAGCAATTTGCGATAAGTGTGACGCCAAGCGGCACTATCAAAAGCTTTACTGCT
GTTGAGCAAGATGGTCAACGCAGTGCTTATACACTGAAAAGCCAGCAAAGTAGCGTGGTTGATGCCAGTA
AGTTTACCTTTACTCCCCCAAAAGGTGTGACGCTGGATGATCAGCGGTA
Protein Information
Protein Name outer-membrane lipoprotein carrier protein
NCBI Protein GI 218928525
Protein Accession YP_002346400
Protein pI 5.79
Protein Weight 20852.54
Protein Length 202
Protein Note participates with LolB in the incorporation of lipoprotein into the outer membrane
Protein Sequence 
>YP_002346400.1 outer-membrane lipoprotein carrier protein [Yersinia pestis CO92]
MKRLLVACCFLSGLISASALADASTDLQNRLSKVNSFHASFSQAVTSSDGAVVQEGEGELWVKRPNLFNW
HMTSPDESVLISDGETLWFYNPFVEQATATWLKNATGNTPFMLITRNNPDDWKQYNVKQKGDDFELTPKS
ASGNLKQFAISVTPSGTIKSFTAVEQDGQRSAYTLKSQQSSVVDASKFTFTPPKGVTLDDQR
Epitope Information
IEDB Linear Epitope