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YerA

General Information
Protegen ID 348
Sequence Strain (Species/Organism) Yersinia pestis CO92
VO ID VO_0011011
Taxonomy ID 214092
Molecule Role Protective antigen
Molecule Role Annotation Using a mouse plague model, YPCD1.05c (yerA) may provide partial protection against challenge with a low dose (20 times the 50% lethal dose [20x LD(50)]) of Y. pestis (Li et al., 2009).
References
Li et al., 2009: Li B, Zhou L, Guo J, Wang X, Ni B, Ke Y, Zhu Z, Guo Z, Yang R. High-throughput identification of new protective antigens from a Yersinia pestis live vaccine by enzyme-linked immunospot assay. Infection and immunity. 2009; 77(10); 4356-4361. [PubMed: 19651863].
Gene Information
Gene Name YerA
NCBI Gene ID 1172650
Genbank Accession AL117189
Locus Tag YPCD1.05c
Plasmid No pCD1
Gene Starting Position 3013
Gene Ending Position 3405
DNA Sequence 
>NC_003131.1:3013-3405 Yersinia pestis CO92 plasmid pCD1, complete sequence
CTCAACTAAATGACCGTGGTGGTGAGATTAGTGATGAGGTTTGTAGCCGTTCAGCCCCCTGCACCAGCAT
CTCAAGCTGAGTATATAGTGAGTTATTATCCAGGCTGTTCAATGGTTGTCGATTCCATAACACTGGGTGC
CCCCCAACCTCGTCCCAGGATAAGATGGGTTTTAATATATCTTGACTGAATATATTATGGCTAAGTAAGG
TTTCCTTTTCATCATTATTGTCAAGAGAAGGTAGGGTAAACATTAATATTTGCCCGACAGGATGCTCTGT
TATATGGCAGGCGAATTCCCCAACTTTGACACCGATAACCGGTTCAATAGTATCTGGAATAGACAACGAA
AGTTGTTGAAATAATTGAGTGATAGCTTGTTCAAATGAATACA
Protein Information
Protein Name secretion chaperone
NCBI Protein GI 16082696
Protein Accession NP_395142
Protein pI 4.34
Protein Weight 13954.77
Protein Length 130
Protein Note chaperone for YopE
Protein Sequence 
>NP_395142.1 secretion chaperone (plasmid) [Yersinia pestis CO92]
MYSFEQAITQLFQQLSLSIPDTIEPVIGVKVGEFACHITEHPVGQILMFTLPSLDNNDEKETLLSHNIFS
QDILKPILSWDEVGGHPVLWNRQPLNSLDNNSLYTQLEMLVQGAERLQTSSLISPPRSFS
Epitope Information
IEDB Linear Epitope