VIOLIN: Vaccine Investigation and Online Information Network

YPO0420

General Information

Protegen ID

349

Sequence Strain (Species/Organism)

Yersinia pestis CO92

VO ID

VO_0011012

Taxonomy ID

214092

Molecule Role

Protective antigen

Molecule Role Annotation

Using a mouse plague model, YPO0420 may provide partial protection against challenge with a low dose (20 times the 50% lethal dose [20x LD(50)]) of Y. pestis (Li et al., 2009).

References

Li et al., 2009: Li B, Zhou L, Guo J, Wang X, Ni B, Ke Y, Zhu Z, Guo Z, Yang R. High-throughput identification of new protective antigens from a Yersinia pestis live vaccine by enzyme-linked immunospot assay. Infection and immunity. 2009; 77(10); 4356-4361. [PubMed: 19651863].

Gene Information

Gene Name

YPO0420

NCBI Gene ID

1173265

Genbank Accession

AL590842

Locus Tag

YPO0420

Gene Starting Position

438148

Gene Ending Position

439230

DNA Sequence

>NC_003143.1:438148-439230 Yersinia pestis CO92 chromosome, complete genome
AGTGAAGATAAAAACAGTAGTCACTCTGCTCATTACGTTCCTTCTCGCCGCCTGCGACAGAACGCCTCCT
GAAACCGTCGAAAGTGTGCGCCCAGTAAAAATCTTTATGGTGGAAGACAGCGGGCAAAATGGTACCCGTT
ATTTCCCGGCCAGGCTGCAAGCGGGTGATGAAACCCAACTCTCCTTTAAACGGGGTGGGCAACTGCAAGA
GTTGTTGGTCCGTGAAGGGGAACAAGTGAAGAAAGGGCAAAAAATTGCCATGTTGAACGATACTGATTTG
AGCTTAAGAGTCAGGGATCGTCAATCAACCTTCAATTTGGCCCGCGATCAGTTTAATCGCTTTAACACCT
TGCAAGGCCGCAGCGCCGTCTCGCGTGCCGATCTGGATATTCGCCGTGCAGAGATGGAGTCAGCGCAAGC
GGCTTTAGACATTGCGCGTAAAGAGCTCAGCGATGCGACAATTATCGCACCTTTCGATGGCATCATTGCC
AATGTGAATGTACGTAATCACCAAGTTATGGCCGCTGGTCAGCCGGTTGCCACCTTGAGTGCGCTGGATA
CGTTGGATGTGGTATTCAGTGTTCCAGAGCGTCTGTTTACCACGCTGGACATCAGCAACCGTAACTACAA
GCCAACGGTATTACTGAACCATATGCCAGGGCGTGAGTTTATTGCTGAATATAAAGAACACACCACTTCG
ACGACCTCTGCTTCACAGACTTTCCAGGTCACGCTGACGATGAAACGCCCAGCAGATATGCCATTGCTTT
CCGGTATCAGTGGCCGGGTCAGAATTAACTCCGGCAATTTGTCTGGCACCGACCATCCAACCATCATCGT
TCCGGTGGAAGCCGTATTTAACCCCGACCATGCGCAGTTGAATGATGCCCGAGTGTGGGTCATTAAGAAT
GATAATGACCAAATGCACGTAGAAGAACGCAAAGTGCAGGTGGGGCAACTCGTGGAAAACGGTATTCAAG
TGACCTCTGGCCTGGCTGATGGCGAACAAATTGTTGCCGCAGGTACCGGTGAGCTTCGCCCACAACAAGT
TGTCCGGGCTTGGGTTCGTGAGCGAGGTCTCTA

Protein Information

Protein Name

lipoprotein

NCBI Protein GI

218927621

Protein Accession

YP_002345496

Protein pI

7.17

Protein Weight

36537.47

Protein Length

360

Protein Note

Similar to Vibrio cholerae putative multidrug resistance protein Vc1675 TR:Q9KRG7 (EMBL: AE004245) (343 aa) fasta scores: E(): 1.2e-22, 30.919% id in 359 aa, and to Pseudomonas aeruginosa probable Rnd efflux membrane fusion protein precursor Pa4374 TR:Q9HW28 (EMBL: AE004853) (376 aa) fasta scores: E(): 2.1e-13, 28.086% id in 324 aa

Protein Sequence

>YP_002345496.1 lipoprotein [Yersinia pestis CO92]
MKIKTVVTLLITFLLAACDRTPPETVESVRPVKIFMVEDSGQNGTRYFPARLQAGDETQLSFKRGGQLQE
LLVREGEQVKKGQKIAMLNDTDLSLRVRDRQSTFNLARDQFNRFNTLQGRSAVSRADLDIRRAEMESAQA
ALDIARKELSDATIIAPFDGIIANVNVRNHQVMAAGQPVATLSALDTLDVVFSVPERLFTTLDISNRNYK
PTVLLNHMPGREFIAEYKEHTTSTTSASQTFQVTLTMKRPADMPLLSGISGRVRINSGNLSGTDHPTIIV
PVEAVFNPDHAQLNDARVWVIKNDNDQMHVEERKVQVGQLVENGIQVTSGLADGEQIVAAGTGELRPQQV
VRAWVRERGL

Epitope Information

IEDB Linear Epitope