VIOLIN: Vaccine Investigation and Online Information Network

HpmB

General Information

Protegen ID

350

Sequence Strain (Species/Organism)

Yersinia pestis CO92

VO ID

VO_0011013

Taxonomy ID

214092

Molecule Role

Protective antigen

Molecule Role Annotation

Using a mouse plague model, YPO3720 (hpmB) may provide partial protection against challenge with a low dose (20 times the 50% lethal dose [20x LD(50)]) of Y. pestis (Li et al., 2009).

References

Li et al., 2009: Li B, Zhou L, Guo J, Wang X, Ni B, Ke Y, Zhu Z, Guo Z, Yang R. High-throughput identification of new protective antigens from a Yersinia pestis live vaccine by enzyme-linked immunospot assay. Infection and immunity. 2009; 77(10); 4356-4361. [PubMed: 19651863].

Gene Information

Gene Name

HpmB

NCBI Gene ID

1176539

Genbank Accession

AL590842

Locus Tag

YPO3720

Gene Starting Position

4156356

Gene Ending Position

4158041

DNA Sequence

>NC_003143.1:4156356-4158041 Yersinia pestis CO92 chromosome, complete genome
TATGATTAGAAAACGTACTGCGTTATGGCTTGTACTCAGTACTGGCGCTCAAGCCGAGACGCCTTTGGCC
ATAGAGACCCCATCTTCCATTAATGAATCTCGCCAGTCACTACAAAATAATGCCAAAGAAATTAATCAGC
TAGTAGAAGAAAAACGCCACCAACAGATCACACAACACAACACCGGACAAAGTGAATTATCTCGTCCGGC
CCCCCCTGCACCGGTGTTACCCGAAGATACGCAGTGCCTACCCATTAATGGCGTTTATATTCAGGGGATC
ACCTTATTAACAGAGGATGATTTAAGTGAATTAAGTGCGATCCCTGAACAATGTATTCATCCTGATAATA
TTAACCTTCTGACCCGTGAACTCACTCATATCTATATGGATAAAGGGTATATCACGGCGCGGATTCAATT
TATTCCACCAGATGCTGACGGAAAATTAGGTCTGGATATTACCGAAGGGTTTGTCGAAGCGATTGATAGC
ACGGACACCGGGTTAGATGGCGAGACGGTATTCCCGAATATGATCGGCAAGCCGCTCAATATTACTCGCC
TTGATCAAGGACTGGACCAGGCAAACCGTTTGCCCTCAAATAAAGTCACCGTCGATATTCTGCCCGGAAC
ACTACCCGGTGGTTCTATTCTTAAACTGCATAATACACCGTCAACGCCCTGGCATTTGACCACCTCGATG
GACAATTACGGTAATAAAAATACCGGTAAATGGCTAAGTCGCAACGCCTTATCTTTCGATAATCCGTTGG
GCTTATCGGATTCCGTCAGTATCAATATCAGCAATACCGTTGATCGCCCCCAACATAATTATAGCCGTGC
TTACTCAATGTTTTATTCGGTCCCTTACGGTGCCTTGACCTTTAGTGGCTTTGGTAGTTATGCCGAATAC
CGTTATCCAATGAAATTGCAGTTTAATACAGCCAAGTTACATGGAGAAACACAGCAACACGGTTTACGGG
CAGATTATGTTTTCTATCGCGATCAAAGCCAGATTAATGGGCTAAGTGCGCAATTAACCTATAAACGGGC
CAGTAATTATCTGAATGAAGAAAAAATTGCTATCAGCAGCCCGACGCTAACAATCTTTGAATTAGGCCTT
AATCACCTGCACGTCCTGCCCATGGGCTTATTCAATATCAATGTCAGCCTTGAGCAGGGCTTGCCTTGGC
TGGGCGCGGAGCGCTCAAATGGCCCATTAGCGAACTATCAAGATAGCCAATTCACTAAAGCTAAGACCTC
AATTACCTCCAATCACTACTTTGCACTGTTTGATGATACCTATCTGTTCAGCAATCAATTTTATGGCCAG
TACACCCGTGACCGGTTACCCGGCGTGGAATGGCTCAGCATCACTGACAGCAGTGCCATCCGTGGCTTTA
GCCGCAATACCTTATCCGCCGACCAAGGCTGGTATTTACAAAACACCCTCTCCCGTCGTTTCACCTTGGG
TGACGCCACGCTAACCCCTCGCGTAGGGCTTGATACGGGCCGTCTCCAGCAAAAACCACAGGGGTGGGTC
AGCGCTATGGGGCTAAGCGCTGGCGTCAGCCTTAATTACCAGAATGCCACCTTGGATATAGAAGCCAGCC
GTGGCCGGTTACTCTCCGGCCCATCGAAGATTAACGATCCAACACAAATTCTGGCGCGTTTTTCTTACCG
CTTTTA

Protein Information

Protein Name

hemolysin activator protein

NCBI Protein GI

218930726

Protein Accession

YP_002348601

Protein pI

6.38

Protein Weight

60678.51

Protein Length

561

Protein Note

Similar to Serratia marcescens hemolysin activator protein precursor ShlB SW:HLYB_SERMA (P15321) (557 aa) fasta scores: E(): 0, 54.2% id in 565 aa, and to Proteus mirabilis hemolysin activator protein precursor HpmB SW:HLYB_PROMI (P16465) (561 aa) fasta scores: E(): 0, 49.0% id in 571 aa

Protein Sequence

>YP_002348601.1 hemolysin activator protein [Yersinia pestis CO92]
MIRKRTALWLVLSTGAQAETPLAIETPSSINESRQSLQNNAKEINQLVEEKRHQQITQHNTGQSELSRPA
PPAPVLPEDTQCLPINGVYIQGITLLTEDDLSELSAIPEQCIHPDNINLLTRELTHIYMDKGYITARIQF
IPPDADGKLGLDITEGFVEAIDSTDTGLDGETVFPNMIGKPLNITRLDQGLDQANRLPSNKVTVDILPGT
LPGGSILKLHNTPSTPWHLTTSMDNYGNKNTGKWLSRNALSFDNPLGLSDSVSINISNTVDRPQHNYSRA
YSMFYSVPYGALTFSGFGSYAEYRYPMKLQFNTAKLHGETQQHGLRADYVFYRDQSQINGLSAQLTYKRA
SNYLNEEKIAISSPTLTIFELGLNHLHVLPMGLFNINVSLEQGLPWLGAERSNGPLANYQDSQFTKAKTS
ITSNHYFALFDDTYLFSNQFYGQYTRDRLPGVEWLSITDSSAIRGFSRNTLSADQGWYLQNTLSRRFTLG
DATLTPRVGLDTGRLQQKPQGWVSAMGLSAGVSLNYQNATLDIEASRGRLLSGPSKINDPTQILARFSYR
F

Epitope Information

IEDB Linear Epitope