VIOLIN: Vaccine Investigation and Online Information Network

caf1

General Information

Protegen ID

355

Sequence Strain (Species/Organism)

Yersinia pestis

VO ID

VO_0011017

Taxonomy ID

632

Other Database IDs

CDD:286355
GOA:P26948
InterPro: IPR008966
InterPro: IPR015335
PDB: 1P5U
PDB: 1P5V
PDB: 1Z9S
PDB: 3DOS
PDB: 3DPB
PDB: 3DSN
UniProtKB/UniProt: P26948

Molecule Role

Protective antigen

Molecule Role Annotation

Vaccination of mice with deF1 DNA conferred protection against subcutaneous infection with the virulent Y. pestis Kimberley53 strain, even at challenge amounts as high as 4,000 50% lethal doses (Grosfeld et al., 2003).

Related Vaccines(s)

Y. pestis DNA vaccine encoding dfF1 Protein

References

Grosfeld et al., 2003: Grosfeld H, Cohen S, Bino T, Flashner Y, Ber R, Mamroud E, Kronman C, Shafferman A, Velan B. Effective protective immunity to Yersinia pestis infection conferred by DNA vaccine coding for derivatives of the F1 capsular antigen. Infection and immunity. 2003 Jan; 71(1); 374-83. [PubMed: 12496187 ].

Gene Information

Gene Name

caf1

Protein Information

Protein Name

F1 capsule antigen

NCBI Protein GI

48621

Protein pI

4.63

Protein Weight

16931.51

Protein Length

223

Protein Note

Caf1 Capsule antigen; pfam09255

Protein Sequence

>CAA43966.1 F1 capsule antigen [Yersinia pestis]
MKKISSVIAIALFGTIATANAADLTASTTATATLVEPARITLTYKEGAPITIMDNGNIDTELLVGTLTLG
GYKTGTTSTSVNFTDAAGDPMYLTFTSQDGNNHQFTTKVIGKDSRDFDISPKVNGENLVGDDVVLATGSQ
DFFVRSIGSKGGKLAAGKYTDAVTVTVSNQ

Epitope Information

IEDB Linear Epitope