VIOLIN: Vaccine Investigation and Online Information Network

apxIA

General Information

Protegen ID

358

Sequence Strain (Species/Organism)

Actinobacillus pleuropneumoniae

VO ID

VO_0011019

Taxonomy ID

754346

Other Database IDs

CDD:308152
CDD:225483
CDD:311996
GOA:P55128
InterPro: IPR001343
InterPro: IPR003995
InterPro: IPR011049
InterPro: IPR013550
InterPro: IPR018504
InterPro: IPR018511
UniProtKB/UniProt: P55128

Molecule Role

Protective antigen

Molecule Role Annotation

The ApxI antigen is an important factor in the protection against Actinobacillus pleuropneumoniae serotype 5 infection; therefore, the protective immunity in mice following oral immunization with Saccharomyces cerevisiae expressing either ApxIA (group C) or ApxIIA (group D) alone or both (group E) was compared with that in two control groups (group A and B). The immunogenicity of the rApxIA antigen derived from the yeast was confirmed by a high survival rate and an ApxIA-specific IgG antibody response (p < 0.01) (Shin et al., 2007).

Related Vaccines(s)

A. pleuropneumoniae ApxIa and ApxIIa protein vaccine , A. pleuropneumoniae ApxIA protein vaccine , A. pleuropneumoniae DNA vaccine pcDNA-apxIA/pcDNA-apxIIA , HS93Tox-/pIG-T1K , mixture of Salmonella strains delivering ApxIA, ApxIIA, ApxIIIA and OmpA of A. pleuropneumoniae , rS.C-APP-ApxI/ApxII

References

Shin et al., 2007: Shin SJ, Shin SW, Kang ML, Lee DY, Yang MS, Jang YS, Yoo HS. Enhancement of protective immune responses by oral vaccination with Saccharomyces cerevisiae expressing recombinant Actinobacillus pleuropneumoniae ApxIA or ApxIIA in mice. Journal of veterinary science. 2007; 8(4); 383-392. [PubMed: 17993753].

Gene Information

Gene Name

apxIA

Protein Information

NCBI Protein GI

312899

Protein pI

5.41

Protein Weight

104857.1

Protein Length

1100

Protein Note

RTX N-terminal domain; pfam02382

Protein Sequence

>CAA51548.1 apxIA [Actinobacillus pleuropneumoniae serovar 9]
MANSQLDRVKGLIDSLNQHTKSAAKSGAGALKNGLGQVKQAGQKLILYIPKDYQASTGSSLNDLVKAAEA
LGIEVHRSEKNGTALAKELFGTTEKLLGFSERGIALFAPQFDKLLNKNQKLSKSLGGSSEALGQRLNKTQ
TALSALQSFLGTAIAGMDLDSLLRRRRNGEDVSGSELAKAGVDLAAQLVDNIASATGTVDAFAEQLGKLG
NALSNTRLSGLASKLNNLPDLSLAGPGFDAVSGILSVVSASFILSNKDADAGTKAAAGIEISTKILGNIG
KAVSQYIIAQRVAAGLSTTAATGGLIGSVVALAISPLSFLNVADKFERAKQLEQYSERFKKFGYEGDSLL
ASFYRETGAIEAALTTINSVLSAASAGVGAAATGSLVGAPVAALVSAITGIISGILDASKQAIFERVATK
LANKIDEWEKKHGKNYFENGYDARHSAFLEDTFELLSQYNKEYSVERVVAITQQRWDVNIGELAGITRKG
SDTKSGKAYVDFFEEGKLLEKEPDRFDKKVFDPLEGKIDLSSINKTTLLKFVTPVFTAGEEIRERKQTGK
YEYMTELFVKGKEKWVVTGVQSHNAIYDYTNLIQLAIDKKGEKRQVTIESHLGEKNDRIYLSSGSSIVYA
GNGHDVAYYDKTDTGYLTFDGQSAQKAGEYIVTKELKADVKVLKEVVKTQDISVGKRSEKLEYRDYELSP
FELGNGIRAKDELHSVEEIIGSNRKDKFFGSRFTDIFHGAKGDDEIYGNDGHDILYGDDGNDVIHGGDGN
DHLVGGNGNDRLIGGKGNNFLNGGDGDDELQVFEGQYNVLLGGAGNDILYGSDGTNLFDGGVGNDKIYGG
LGKDIYRYSKEYGRHIIIEKGGDDDTLLLSDLSFKDVGFIRIGDDLLVNKRIGGTLYYHEDYNGNALTIK
DWFKEGKEGQNNKIEKIVDKDGAYVLSQYLTELTAPGRGINYFNGLEEKLYYGEGYNALPQLRKDIEQII
SSTGAFTGDHGKVSVGSGGPLVYNNSANNVANSLSYSLAQAA

Epitope Information

IEDB Linear Epitope