VIOLIN: Vaccine Investigation and Online Information Network

RAP-1

General Information

Protegen ID

368

Sequence Strain (Species/Organism)

Babesia bovis T2Bo

VO ID

VO_0011026

Taxonomy ID

484906

Molecule Role

Protective antigen

Molecule Role Annotation

RAP-1 (21B4) is a candidate for inclusion in a B. bovis vaccine based on its ability to induce partial protection in vaccinates, defined as a significant reduction in parasitemia upon challenge (Wright et al., 1992).

References

Wright et al., 1992: Wright IG, Casu R, Commins MA, Dalrymple BP, Gale KR, Goodger BV, Riddles PW, Waltisbuhl DJ, Abetz I, Berrie DA. The development of a recombinant Babesia vaccine. Veterinary parasitology. 1992; 44(1-2); 3-13. [PubMed: 1441189].

Gene Information

Gene Name

RAP-1

NCBI Gene ID

5479143

Genbank Accession

AAXT01000002

Chromosome No

Locus Tag

BBOV_IV009870

Gene Starting Position

1308099

Gene Ending Position

1310097

DNA Sequence

>NW_001820857.1:1308099-1310097 Babesia bovis T2Bo chromosome 4 gcontig_1104837696308, whole genome shotgun sequence
ACTATTGTTTGTATCTTTCGACGGATAGTATTTTACATATACATTTGTCGGCTTTTATATATAGCAGTGC
TATAGACAAACAATACACAGATTAATCTTTAGATACTAAGTTCAATAATATTACGGACATATTGTAGACA
ATGAGAATCATTAGCGGCGTTGTCGGTTGCCTTTTCTTGGTGTTTTCACACCATGTGTCTGCTTTTCGCC
ACAATCAGAGAGTAGGAAGTCTCGCTCCAGCTGAAGTGGTAGGTGATTTAACCTCCACATTGGAAACAGC
TGATACTTTGATGACTCTCCGTGACCACATGCACAACATTACTAAGGATATGAAACATGTTTTGAGCAAT
GGCCGTGAGCAGATTGTAAATGATGTTTGCTCTAATGCTCCTGAGGACTCCAACTGTCGTGAGGTAGTTA
ACAATTATGCTGACCGTTGTGAAATGTACGGATGCTTTACGATTGACAATGTCAAATATCCGTTGTATCA
AGAGTACCAACCTCTATCTCTTCCAAACCCTTACCAGTTGGATGCTGCGTTCAGATTGTTCAAAGAGAGT
GCATCCAATCCTGCTAAGAACAGCGTAAAACGCGAATGGTTGCGTTTCAGAAATGGAGCGAACCATGGTG
ATTACCACTACTTCGTCACTGGTCTGTTGAACAACAATGTTGTGCACGAGGAAGGAACTACCGATGTTGA
ATATCTTGTCAACAAGGTACTCTATATGGCTACCATGAACTACAAGACTTATTTGACAGTAAACAGTATG
AACGCCAAGTTTTTCAACAGATTCAGCTTCACTACAAAGATATTCAGCCGTCGTATTAGGCAAACATTGA
GTGATATCATCAGGTGGAATGTTCCTGAAGATTTTGAAGAAAGGAGCATCGAACGTATCACTCAACTTAC
TAGCAGCTACGAAGATTACATGTTGACCCAGATTCCAACTCTTTCCAAGTTTGCACGTCGTTATGCTGAC
ATGGTGAAGAAGGTTCTGCTCGGTAGCTTGACCTCGTACGTTGAAGCTCCTTGGTACAAAAGATGGATAA
AGAAATTCAGAGACTTTTTCTCTAAAAACGTTACCCAACCTACAAAGAAGTTCATCGAGGATACTAACGA
AGTTACCAAAAACTATCTGAAAGCCAATGTTGCTGAGCCCACTAAAAAGTTTATGCAGGACACTCACGAA
AAAACCAAAGGCTATCTGAAAGAGAATGTAGCCGAACCTACTAAGACTTTTTTCAAGGAGGCTCCTCAAG
TCACCAAACACTTCTTCGATGAGAACATTGGCCAACCCACCAAGGAGTTTTTCAGGGAAGCTCCCCAAGC
CACTAAACATTTCCTAGACGAAAACATCGGTCAACCAACCAAGGAGTTCTTCAGGGAGGCTCCCCAAGTC
ACTAAGCACTTCTTAGACGAGAATATTGCTCAACCTACTAAAGAATTTTTCAGGGATGTCCCTCAAGTCA
CCAAGAAGGTTATAACTGAGAACATTGCTCAACCAACTAAGGAATTCCTTAAGGAGGTTCCTCATACTAC
CATGAAAGTCTTGAATGAAAACATTGCTCAACCTGCCAAGGAAATCATACATGAGTTTGGTACTGGCGCC
AAGAATTTCATTTCCGCAGCCCATGAAGGTACTAAGCAGTTCTTAAACGAAACTGTTGGCCAACCTACAA
AGGAATTCCTGAACGGAGCTCTAGAAACTACTAAAGACGCATTACACCATCTGGGTAAATCATCAGACGA
AGCCAACATTTATGATGCCTCGGAAAATACCACTCAGTCTAACGACTCAACTACTTCCAACGGTGAAGAC
ACCGCCGGATACCTCTGATGAGATGCGTTTATAATGGCACAAACTCAGCAAATGATGTATCGTCATCTGA
TCCATCGGTTTTCAATATTGTATTGGATGCAATATCTGAATGCATACGATGCGACAGTTTCCATCATCGG
GTGCCGAATCGTAACTCTCAAAACACCATTTTAAGTTAT

Protein Information

NCBI Protein GI

156087004

Protein Accession

XP_001610909

Protein pI

7.16

Protein Weight

61365.28

Protein Length

565

Protein Sequence

>XP_001610909.1 rhoptry-associated protein 1 (RAP-1) [Babesia bovis T2Bo]
MRIISGVVGCLFLVFSHHVSAFRHNQRVGSLAPAEVVGDLTSTLETADTLMTLRDHMHNITKDMKHVLSN
GREQIVNDVCSNAPEDSNCREVVNNYADRCEMYGCFTIDNVKYPLYQEYQPLSLPNPYQLDAAFRLFKES
ASNPAKNSVKREWLRFRNGANHGDYHYFVTGLLNNNVVHEEGTTDVEYLVNKVLYMATMNYKTYLTVNSM
NAKFFNRFSFTTKIFSRRIRQTLSDIIRWNVPEDFEERSIERITQLTSSYEDYMLTQIPTLSKFARRYAD
MVKKVLLGSLTSYVEAPWYKRWIKKFRDFFSKNVTQPTKKFIEDTNEVTKNYLKANVAEPTKKFMQDTHE
KTKGYLKENVAEPTKTFFKEAPQVTKHFFDENIGQPTKEFFREAPQATKHFLDENIGQPTKEFFREAPQV
TKHFLDENIAQPTKEFFRDVPQVTKKVITENIAQPTKEFLKEVPHTTMKVLNENIAQPAKEIIHEFGTGA
KNFISAAHEGTKQFLNETVGQPTKEFLNGALETTKDALHHLGKSSDEANIYDASENTTQSNDSTTSNGED
TAGYL

Epitope Information

IEDB Linear Epitope