VIOLIN: Vaccine Investigation and Online Information Network

12D3

General Information

Protegen ID

371

Sequence Strain (Species/Organism)

Babesia bovis T2Bo

VO ID

VO_0011027

Taxonomy ID

484906

Molecule Role

Protective antigen

Molecule Role Annotation

Crude extracts of Babesia bovis parasites were systematically fractionated and tested in numerous sequential vaccination/challenge experiments in adult cattle. Two of these, GST-12D3 and GST-11C5, when used in combination were almost as protective as has been previously shown for the commercially available live attenuated vaccine (Wright et al., 1992).

Related Vaccines(s)

B. bovis GST-12D3

References

Wright et al., 1992: Wright IG, Casu R, Commins MA, Dalrymple BP, Gale KR, Goodger BV, Riddles PW, Waltisbuhl DJ, Abetz I, Berrie DA. The development of a recombinant Babesia vaccine. Veterinary parasitology. 1992; 44(1-2); 3-13. [PubMed: 1441189].

Gene Information

Gene Name

12D3

NCBI Gene ID

5478971

Genbank Accession

AAXT01000002

Chromosome No

Locus Tag

BBOV_IV008150

Gene Starting Position

946834

Gene Ending Position

948172

DNA Sequence

>NW_001820857.1:946834-948172 Babesia bovis T2Bo chromosome 4 gcontig_1104837696308, whole genome shotgun sequence
TGGCTGACGTCTACCGTCATTTTGACATGCACTGCGTTGCAGCTCGTGCATAGCTTTCGAGTGTTTCATC
TGGGTAAGGGTACAACGTTTTGTCGCGTCAACGTTAAGGCGCATTTCTTCTGATTTTAGCAAGAACGTCG
ACTATATTAAATTCACTTGGTCGGCTTCTTGTGACGCCTACTATTGCTGCGAGAGTGTGTAGGTTTTTCC
TTCAGGCATTACTCTGGAAAATACTATTCGACATACAAGATGTTGGCTACACGTTTTATTTTTAGTCTTT
GCCTATTTGTGGCTCATCAAGGCGTCAACGCCTTTTTCTATCGTGCAGTTCCTATGTACGATCAGAATGG
TAAGCTGGTTCCGGATTCCTCTAATATAGGTCCTTCATCCTTACGAATCGAGGCTACTGGTGTTGGTAGG
ATTTGTTCTACTATGCAATCAGGTATCTATCTCATCAATCCTTACGCTCAGCGCTGCCCAATTGGGAAGA
GCAAATGTGGACCTGAGCATGATTCCACCCTAGGAAAGTGTGCCATGTACTCTGGTTGTTACACCATCAG
TAACGACTTCCGTGCTTGCTCATGCTTGCCTGATTACTTCGGCAACCCTTACAAGCAATGCTTCAGACAC
TGTGACACGGATTTGGACTGCCCTTCACCTTATGCTGAGTGCAGGATGGACGCAGGCGAGACGATCAAGC
GCTGCAAGTGCAGAGCAGGTTGCCCAGGTGATGGTGTCATTTGCAAGCCCGATAAGATCTGTACTGACTT
GGCTGAAGACTCTGAGGCTCACCGTAGGTGCCTTCAGACCGGTATCACCGACAAGACATACGTTTGTGAT
GACGGTTATTACTTGGACACTGATAACAAGTGCCAGCCGATTGTTGAGCTTGAAGATGATAGGGTTGTGA
GCGTAATTGCCAGTGGCTACGTAAACGGCAGCCGTATTGATATTGGTAACTGCTTTTCAATTGAAATTAA
CAAAGACAACGGTATGTCTTACTTCTACCAACTTAACAGTGGTGACCCCGTTGTGATTGACCAAAAAATT
AAGACCGACGACCAGTTGATGTTGTTGTTCGAGGTTAAGGCTAATGACATTATTGCCTTTACCACTACTG
AGGCCAACCCTTCTGGTCTCACTAAAATCTTCACTATCTCAAATGGTCTTAAAGGCTGCAAAATCGACAG
TGTTATGAAGTACTCCCCAACCGGAGCTAAGGAGCACCCCTCAGGTGTCAGGGTTGAGGTTAAAGAGCTT
GAAACTTCGAGCGAAAGGCAGGAGCTTTAGTCAAAATGACGAACCGACTCAAATAGAGTTTAATTTTTTG
TAGAAAATT

Protein Information

NCBI Protein GI

156086656

Protein Accession

XP_001610737

Protein pI

5.11

Protein Weight

36321.83

Protein Length

346

Protein Sequence

>XP_001610737.1 12D3 antigen [Babesia bovis T2Bo]
MLATRFIFSLCLFVAHQGVNAFFYRAVPMYDQNGKLVPDSSNIGPSSLRIEATGVGRICSTMQSGIYLIN
PYAQRCPIGKSKCGPEHDSTLGKCAMYSGCYTISNDFRACSCLPDYFGNPYKQCFRHCDTDLDCPSPYAE
CRMDAGETIKRCKCRAGCPGDGVICKPDKICTDLAEDSEAHRRCLQTGITDKTYVCDDGYYLDTDNKCQP
IVELEDDRVVSVIASGYVNGSRIDIGNCFSIEINKDNGMSYFYQLNSGDPVVIDQKIKTDDQLMLLFEVK
ANDIIAFTTTEANPSGLTKIFTISNGLKGCKIDSVMKYSPTGAKEHPSGVRVEVKELETSSERQEL

Epitope Information

IEDB Linear Epitope