VIOLIN: Vaccine Investigation and Online Information Network

ptxD

General Information

Protegen ID

377

Sequence Strain (Species/Organism)

Bordetella pertussis

VO ID

VO_0011032

Taxonomy ID

520

Other Database IDs

CDD:286372
GOA:C0MPK8
InterPro: IPR008992
InterPro: IPR015355
UniProtKB/TrEMBL: C0MPK8

Molecule Role

Protective antigen

Molecule Role Annotation

BALB/c mice were immunized with PTx vaccine on day 6 of life and then challenged with B. pertussis using the aerosol challenge model. These primed mice were significantly better protected against leukocytosis, weight loss, and proliferation of B. pertussis in the lungs following aerosol challenge than the nonprimed group. This protection correlated with levels of anti-PT antibody in serum present on the day of aerosol challenge (Bruss and Siber, 2002).

Related Vaccines(s)

B. pertussis PTx protein vaccine

References

Bruss and Siber, 2002: Bruss JB, Siber GR. Quantitative priming with inactivated pertussis toxoid vaccine in the aerosol challenge model. Infection and immunity. 2002; 70(8); 4600-4608. [PubMed: 12117973].

Gene Information

Gene Name

ptxD

Protein Information

Protein Name

pertussis toxin subunit 4 precursor

NCBI Protein GI

225311181

Protein pI

10.82

Protein Weight

15542.962

Protein Length

227

Protein Note

Pertussis toxin S4 subunit; pfam09275

Protein Sequence

>CAX52305.1 pertussis toxin subunit 4 precursor [Bordetella pertussis]
MLRRFPTRTTAPGQGGARRSRVRALAWLLASGAMTHLSPALADVPYVLVKTNMVVTSVAMKPYEVTPTRM
LVCGIAAKLGAAASSPDAHVPFCFGKDLKRPGSSPMEVMLRAVFMQQRPLRMFLGPKQLTFEGKPALELI
RMVECSGKQDCP

Epitope Information

IEDB Linear Epitope