VIOLIN: Vaccine Investigation and Online Information Network

rtxA1

General Information

Protegen ID

3836

Sequence Strain (Species/Organism)

Vibrio vulnificus

Taxonomy ID

672

Other Database IDs

CDD:288492
CDD:289465
CDD:294717
CDD:288550

Molecule Role

Protective antigen

Molecule Role Annotation

(Lee et al., 2014)

References

Lee et al., 2014: Lee TH, Kim MH, Lee CS, Lee JH, Rhee JH, Chung KM. Protection against Vibrio vulnificus infection by active and passive immunization with the C-terminal region of the RtxA1/MARTXVv protein. Vaccine. 2014; 32(2); 271-276. [PubMed: 24252692].

Gene Information

Gene Name

rtxA1

Protein Information

Protein Name

putative RTX-toxin

NCBI Protein GI

ADX36405

Protein pI

Protein Weight

240654.284

Protein Length

2436

Protein Note

biotype: 1; PCR_primers=fwd_name: CMCP6-VV2-for-5370, fwd_seq: tgctgtggcgaaaagtaacg

Protein Sequence

>ADX36405.1 putative RTX-toxin, partial [Vibrio vulnificus]
QINAGIRGKNSGSTISSMFTETNTDSIVVPTAASQDVVRKEIRISGVNLEGLGEASHDTAESLVSARAEK
VANLYRWLDTDNDAATDKYVPVPGFERVDADVSDEAKERMIQFVGGYIEHTDNQVPKDQAQALATLFVEA
TLDYDWDKRVEFLTKLESYGYSFEAPHGEKSIVSFWSGRNFKEYRNVLDNAQADGKKVVYDIDVKGNAFA
IDLNKQLMRWGGMFLDPDNAEQNQLKSSIDAATFSNTGFWSSVYATGAQNDVYVIAEGGMRLGNYFWNVE
LPALRQLQREGLVGEIRLLGKPVSAYKDIPVEDIGRRLTDAGVAVKVRFDALSHEKQADLLADNPDGYKA
DTLVELDVKLSAIDSMLRESLPFYSLRTERNLLVQEGEEGFEVRSWPGTDGKSKTILLDNPEDAAQQKSI
ERFILANFDNFEQMPDELFLVDNKVLSHHDGRTRILALKEDGAWTYNANVELMSVTELLDAAHVSGKVRG
ESYQQVIDALTEYHASTAEHADYELTSVEKLLNLRKQVEGYVLGHPDSGRVQAMNALLNQVNSRLEAVSV
LVVSEQSIKAHDSFSHLYDQLDNANLKESKHLYLDGNGDFVTKGKGNLANIDKLGGSGAVLEKVKAAVSH
EYGQVVADTIFAGLSANDLAKDGKGIDIAGLNKVHQAIEQHMSPVSATMYIWKPSDHSALGHAALQIGQG
RTQLEGQAAADFNKQNYVSWWPPGSKSSNIRNIFNVATEDQPDLKLRWSDFSQPAHQNDTLEHDMASEEN
DGFGLKDGETKLKRFIEKLNAAKGIDASYKDASEGYASVLLGNPDMLASTGIPAHVFQPFVDQWNDTSYD
MMDVANRFAEELQKQAQASGDPALVEKRIDNVVRLFAERAIEEIEAFKASQADEGRVFRINLEGLDVAAM
QAEWNRLSNDPDARYQLLTKNCSSTVAKVLKAGGADKLIGHTWRPKFGVWTPTELFNFGQALQEAQLEIA
AKKQSHQVTDVLDALSGNEKHKENVAIENDGTPPRDKESLSPLTRFLNNELYGEKDARRKIGDITQTLLD
HAVENGESQKVTLKGEAGRLTGYYHQGAASSEGETSATSGKVVLFLHGSGSSAEEQASAIRNHYQKQGID
MLAVNLRGYGESDGGPSEKGLYQDARTMFNYLVNDKGIDPSNIIIHGYSMGGPIAADLARYAAQNGQAVS
GLLLDRPMPSMTKAITAHEVANPAGIVGAIAKAVNGQFSVEKNLKGLPKETPILLLTDNEGLGEEGEKLR
AKLAIAGYNVTGEQTFYGHEASNRLMGQYTDQIVSGLFNAEQAAVEAGEVLKGLEKDFKRYGDALKPDTS
VPGKAKDIRTTKDFLNGYKNDHAKEIVDGFRSDMNIKQLVDLFVKGNWSAEQKGALAWEIESRALKVTFQ
NKSEKYNRLFREIASAGVVDAKATEQLAPQLMLLNLANDGFGGRCDPLSKLVLVAKQLENDGQVGVARQL
LEKMYSAAAVLSNPTLYSDSEKANASKLLSSLAAIHAKNPMHDTSMKVWQEKLEGKQALTVNGVVEKITD
ASANGKPVLLELDAPGQAMAAWAKGSGDDRVYGFYDPNAGIVEFSSAEKFSAYLTRFFGKSDLDMAQRYE
LGKNAAGEPIFNRVVVMDGNTLASYKPTFGDKTTMQGILDLPVFDATPIKKPTGGVASDLEALGDKTKVV
VDLAQIFTVQELKERAKVFAKPIGASYQGILDQLDLVHQAKGRDQIAASFELNKKINAYIAEHPTSGRNQ
ALTQLKEQVTSALFIGKMQIAQAGIDAIAQTRPELAARIFTVAIEEANGKHVGLTDMMVRWANEDPYLAP
KHGYKGETPSDLGFDAKYHVDLSEHYADFKQWLETSQSNGLLSKATLDESTKTVHLGYSYQELQDLTGVE
SVQMAFYFLKEAAKKADPISGDSAEMTLLKKFADQSYLSQLDSDRMDQIEGIYRSSHETDVDAWDRRYSG
KGYDELTNKLASATGVDEQLSVLLDDRKGLLIGEVHGSDVNGLRFVNEQMDALKKQGVTVIGLEHLRSDL
AQPLIDRYLATGVMSSELSAMLKTKHLDVALFENARANGMRIVALDANSSARPNVQGTEHGLMYRAGAAN
NIAVEVLQNLPDGEKFVAIYGKAHLQSHKGIEGFVPGITHRLDLPALKVSDSNQFTVEQDDVSLRVVYDD
VANKPKITFKDSLSGANTDLHNQNVNDWERVVVTPTADGGETRFDGQIIVQMENDAVAAKAAANLAGKHP
ESSVVVQLDSDGNYRVVYGDPSKLDGKLRWQLVGHGRDDSESNNTRLSGYSADELAVKLAKFQQSFNQAE
NVSSKPDHISIVGCSLVSDDKQKGFGHQFIN

Epitope Information

IEDB Linear Epitope

QINAGIRGKNSGSTISSMFTETNTDSIVVPTAASQDVVRKEIRISGVNLEGLGEASHDTAESLVSARAEKVANLYRWLDTDNDAATDKYVPVPGFERVDADVSDEAKERMIQFVGGYIEHTDNQVPKDQAQALATLFVEATLDYDWDKRVEFLTKLESYGYSFEAPHGEKSIVSFWSGRNFKEYRNVLDNAQADGKKVVYDIDVKGNAFAIDLNKQLMRWGGMFLDPDNAEQNQLKSSIDAATFSNTGFWSSVYATGAQNDVYVIAEGGMRLGNYFWNVELPALRQLQREGLVGEIRLLGKPVSAYKDIPVEDIGRRLTDAGVAVKVRFDALSHEKQADLLADNPDGYKADTLVELDVKLSAIDSMLRESLPFYSLRTERNLLVQEGEEGFEVRSWPGTDGKSKTILLDNPEDAAQQKSIERFILANFDNFEQMPDELFLVDNKVLSHHDGRTRILALKEDGAWTYNANVELMSVTELLDAAHVSGKVRGESYQQVIDALTEYHASTAEHADYELTSVEKLLNLRKQVEGYVLGHPDSGRVQAMNALLNQVNSRLEAVSVLVVSEQSIKAHDSFSHLYDQLDNANLKESKHLYLDGNGDFVTKGKGNLANIDKLGGSGAVLEKVKAAVSHEYGQVVADTIFAGLSANDLAKDGKGIDIAGLNKVHQAIEQHMSPVSATMYIWKPSDHSALGHAALQIGQGRTQLEGQAAADFNKQNYVSWWPPGSKSSNIRNIFNVATEDQPDLKLRWSDFSQPAHQNDTLEHDMASEENDGFGLKDGETKLKRFIEKLNAAKGIDASYKDASEGYASVLLGNPDMLASTGIPAHVFQPFVDQWNDTSYDMMDVANRFAEELQKQAQASGDPALVEKRIDNVVRLFAERAIEEIEAFKASQADEGRVFRINLEGLDVAAMQAEWNRLSNDPDARYQLLTKNCSSTVAKVLKAGGADKLIGHTWRPKFGVWTPTELFNFGQALQEAQLEIAAKKQSHQVTDVLDALSGNEKHKENVAIENDGTPPRDKESLSPLTRFLNNELYGEKDARRKIGDITQTLLDHAVENGESQKVTLKGEAGRLTGYYHQGAASSEGETSATSGKVVLFLHGSGSSAEEQASAIRNHYQKQGIDMLAVNLRGYGESDGGPSEKGLYQDARTMFNYLVNDKGIDPSNIIIHGYSMGGPIAADLARYAAQNGQAVSGLLLDRPMPSMTKAITAHEVANPAGIVGAIAKAVNGQFSVEKNLKGLPKETPILLLTDNEGLGEEGEKLRAKLAIAGYNVTGEQTFYGHEASNRLMGQYTDQIVSGLFNAEQAAVEAGEVLKGLEKDFKRYGDALKPDTSVPGKAKDIRTTKDFLNGYKNDHAKEIVDGFRSDMNIKQLVDLFVKGNWSAEQKGALAWEIESRALKVTFQNKSEKYNRLFREIASAGVVDAKATEQLAPQLMLLNLANDGFGGRCDPLSKLVLVAKQLENDGQVGVARQLLEKMYSAAAVLSNPTLYSDSEKANASKLLSSLAAIHAKNPMHDTSMKVWQEKLEGKQALTVNGVVEKITDASANGKPVLLELDAPGQAMAAWAKGSGDDRVYGFYDPNAGIVEFSSAEKFSAYLTRFFGKSDLDMAQRYELGKNAAGEPIFNRVVVMDGNTLASYKPTFGDKTTMQGILDLPVFDATPIKKPTGGVASDLEALGDKTKVVVDLAQIFTVQELKERAKVFAKPIGASYQGILDQLDLVHQAKGRDQIAASFELNKKINAYIAEHPTSGRNQALTQLKEQVTSALFIGKMQIAQAGIDAIAQTRPELAARIFTVAIEEANGKHVGLTDMMVRWANEDPYLAPKHGYKGETPSDLGFDAKYHVDLSEHYADFKQWLETSQSNGLLSKATLDESTKTVHLGYSYQELQDLTGVESVQMAFYFLKEAAKKADPISGDSAEMTLLKKFADQSYLSQLDSDRMDQIEGIYRSSHETDVDAWDRRYSGKGYDELTNKLASATGVDEQLSVLLDDRKGLLIGEVHGSDVNGLRFVNEQMDALKKQGVTVIGLEHLRSDLAQPLIDRYLATGVMSSELSAMLKTKHLDVALFENARANGMRIVALDANSSARPNVQGTEHGLMYRAGAANNIAVEVLQNLPDGEKFVAIYGKAHLQSHKGIEGFVPGITHRLDLPALKVSDSNQFTVEQDDVSLRVVYDDVANKPKITFKDSLSGANTDLHNQNVNDWERVVVTPTADGGETRFDGQIIVQMENDAVAAKAAANLAGKHPESSVVVQLDSDGNYRVVYGDPSKLDGKLRWQLVGHGRDDSESNNTRLSGYSADELAVKLAKFQQSFNQAENVSSKPDHISIVGCSLVSDDKQKGFGHQFIN