These results demonstrate that epitopes in fragment 1 are recognized by T cells and antibodies during infection and that immunization with this portion of TprK most effectively attenuates syphilitic lesion development.(Morgan et al., 2002) N-terminal conserved region of TprF elicits strong T-cell responses during infection with different T. pallidum subsp. pallidum isolates(Sun et al., 2004)
References
Morgan et al., 2002: Morgan CA, Lukehart SA, Van Voorhis WC. Immunization with the N-terminal portion of Treponema pallidum repeat protein K attenuates syphilitic lesion development in the rabbit model. Infection and immunity. 2002; 70(12); 6811-6816. [PubMed: 12438357].
Sun et al., 2004: Sun ES, Molini BJ, Barrett LK, Centurion-Lara A, Lukehart SA, Van Voorhis WC. Subfamily I Treponema pallidum repeat protein family: sequence variation and immunity. Microbes and infection. 2004; 6(8); 725-737. [PubMed: 15207819].
