VIOLIN: Vaccine Investigation and Online Information Network

ptxC

General Information

Protegen ID

385

Sequence Strain (Species/Organism)

Bordetella pertussis

VO ID

VO_0011038

Taxonomy ID

520

Other Database IDs

CDD:308828
CDD:280986
GOA:Q546I1
InterPro: IPR003899
InterPro: IPR005138
InterPro: IPR008992
InterPro: IPR016187
InterPro: IPR020063
UniProtKB/TrEMBL: Q546I1

Molecule Role

Protective antigen

Molecule Role Annotation

BALB/c mice were immunized with PTx vaccine on day 6 of life and then challenged with B. pertussis using the aerosol challenge model. These primed mice were significantly better protected against leukocytosis, weight loss, and proliferation of B. pertussis in the lungs following aerosol challenge than the nonprimed group. This protection correlated with levels of anti-PT antibody in serum present on the day of aerosol challenge (Bruss and Siber, 2002).

Related Vaccines(s)

B. pertussis PTx protein vaccine

References

Bruss and Siber, 2002: Bruss JB, Siber GR. Quantitative priming with inactivated pertussis toxoid vaccine in the aerosol challenge model. Infection and immunity. 2002; 70(8); 4600-4608. [PubMed: 12117973].

Gene Information

Gene Name

ptxC

Protein Information

Protein Name

pertussis toxin subunit 3 precursor

NCBI Protein GI

225311183

Protein pI

8.76

Protein Weight

24184.712

Protein Length

303

Protein Note

Aerolysin/Pertussis toxin (APT) domain; pfam03440

Protein Sequence

>CAX52307.1 pertussis toxin subunit 3 precursor [Bordetella pertussis]
MLINNKKLLHHILPILVLALLGMRTAQAVAPGIVIPPKALFTQQGGAYGRCPNGTRALTVAELRGNAELQ
TYLRQITPGWSIYGLYDGTYLGQAYGGIIKDAPPGAGFIYRETFCITTIYKTGQPAADHYYSKVTATRLL
ASTNSRLCAVFVRDGQSVIGACASPYEGRYRDMYDALRRLLYMIYMSGLAVRVHVSKEEQYYDYEDATFQ
TYALTGISLCNPAASIC

Epitope Information

IEDB Linear Epitope