VIOLIN: Vaccine Investigation and Online Information Network

UL44

General Information

Protegen ID

393

Sequence Strain (Species/Organism)

Bovine alphaherpesvirus 1

VO ID

VO_0011043

Taxonomy ID

10320

Molecule Role

Protective antigen

Molecule Role Annotation

A DNA vaccine expressing glycoprotein C (gC, UL44) of bovine herpesvirus-1 (BHV-1) was evaluated for inducing immunity in bovines. Results indicate that DNA immunization with gC could induce neutralizing antibody and lymphoproliferative responses with BHV-1 responsive memory B cells in bovines. However, the immunity developed sufficient for only partial protection against BHV-1 challenge (Gupta et al., 2001).

Related Vaccines(s)

Bovine herpesvirus 1 DNA vaccine AdCMVgC , Bovine herpesvirus 1 DNA vaccine pRSV-gC

References

Gupta et al., 2001: Gupta PK, Saini M, Gupta LK, Rao VD, Bandyopadhyay SK, Butchaiah G, Garg GK, Garg SK. Induction of immune responses in cattle with a DNA vaccine encoding glycoprotein C of bovine herpesvirus-1. Veterinary microbiology. 2001; 78(4); 293-305. [PubMed: 11182496].

Gene Information

Gene Name

UL44

NCBI Gene ID

4783424

Genbank Accession

KC756965

Locus Tag

BoHV1_gp105

Gene Starting Position

16612

Gene Ending Position

18208

DNA Sequence

>NC_001847.1:16612-18208 Bovine herpesvirus 1, complete genome
GTTTATTATGAAATTGTACATGCGTGGTCTTTGGGGGGGGGCGCGGCGGCTTTGCCGTCGGGGCCCCGCG
CCTACAGGCGCGCCCGGGCCTTGCGCCGCAGGCACGAGGCCGCCACCAGCAGGAGCCCCACGGCGCCGAG
ACCGCAGGCGACGGCCACGACGCTGACGAGGACGGGGCTTCCGATTAGGCCGGGCGAGGCGTCGTACGTG
GCGGTCGCGGAGAACTCGGGCAGCGGTGCCGGGTAGCCAGTGGCGGTGCAGGTGTAGTCGACGGGCCCGT
CGGTTGTAGAAAGCAGGCGCACGCCGCGCAGGTTTACCAGCCCGGGCCGCTCGGCGCAGACGCCGGTCTG
CTCAGTGCGCGACGGGGCGATGCCGTCGCGCACCGTCCAGCGCAGGGAGACGCGCCCCTCGGGGACGCAG
CGCGCCTCGCAGACGGCCTCGCCGCCCTCGAAGTACACGCGCAGCTCGGGCGGGCGGTAAACGGCCGGCG
TGCCAGCCGCGTAAAAGCGGCGCTCCATGTTAGCGCTCTGGAACCAGGAGACGTCGCAGCGCAGGTTGGG
CGGGTGGGCGGTTGGCGTCGCGTCCTCGAGCGTAAGGACGGACGTGCGCGAAAAGAGCCCGGAGTCGTCG
ACCGTAAAGACGTCGCGCGCGTGCCGAGCCTCCACGGGGTAGCCGTTGCGGAACCAGTGCAGGCGCGTGG
AGCGCGGCGGGTAGTACTCGGCGGCGCGGCACACGGCCGCGTAGCCGGCGCCTTCTAGCGCTGGCTGGGG
TTCGACGGAAACAGCGGGCGCGCGGTGCGTCGTGACGGTCACGACCTTGCGCTGTGACTTGGTGCCCATG
TCGCGGCGCCAAGTGTACACGCCCTCGGTGGCGGCCGTCAGGGAGCGCACGGTCAGGGGCAAGTTGCGGG
GGTCGGCGGGCGAAGGGAAAATATAGTTGTCGCCCAGCTCCGCGCTACGGTACGCGATCGAGCCGTTCTG
GGCTACGAACAGCAGCACGGGCGGGGCCCGCGGAAAGGGGTTGCGCACGGCCTCGTCGTCGCCGCGCGTG
GAGCGGAACCTGCCCACGCGCTGAAACCAGAGCTCCAGGCGCGCACCGCCAGTGGCGTTGTCGGCCACGC
CGCAGTGCACGTACAGCGGCTCGGCGTACGAGGCGGCCACGGCCTCGCGCTCGCAGAGCATCCACTTGCG
CTCCTTCGGCGGGGCTTTGCTCGGCCGCGGGGGGCGAGGCCGCCCCCCGCCGCTAGGTCGCCCATCGCGG
CTCGCGTTGCCAGCGCCGCCGGGTCGCCCGTCCTCGGGCGGGGCGGGCGGCGGCGTGCTGTTGGTAACGG
GCGGGTCGTGCTCGGACACGGACGGCGGCTCCGGCGTCCCCACGGGCGTAGTAGCACCGGGCGTGCTGTC
CTCTGGCGTAGCGTCGGGGCTGTTGGGCGTGGGGGGCGTTGCGCCGGTGGTCCCAGCGGAGCTTTCCGTC
TCGGTTGGGGACGGGGAGGGCGGAGGCGAGGGCGAGGCTTCCGCCTCCTCGGCGAGCCCCCGCCGGGCAG
ACAGGAGCGCCCAGGCGAAAATAGCTGCGATCAGCCACGCTCGCCCCAGCGGGCCCA

Protein Information

Protein Name

envelope glycoprotein C

NCBI Protein GI

9629830

Protein Accession

NP_045314

Protein pI

8.25

Protein Weight

50150.91

Protein Length

508

Protein Note

envelope glycoprotein C; the Herpesviridae are non-segmented dsDNA viruses with genomes ranging from 120-230kbp; although herpes viruses vary greatly in sequence identity and homology, they all share four common elements: an envelope, a tegument which is composed of viral enzymes, a capsid of 162 capsomers, and a core composed of genomic DNA;virion envelope glycoproteins bind to cellular receptors; the nonessential glycoprotein gC interacts with cell surface proteoglycans, whereas the essential glycoprotein gD is involved in stable secondary attachment

Protein Sequence

>NP_045314.1 envelope glycoprotein C [Bovine alphaherpesvirus 1]
MGPLGRAWLIAAIFAWALLSARRGLAEEAEASPSPPPSPSPTETESSAGTTGATPPTPNSPDATPEDSTP
GATTPVGTPEPPSVSEHDPPVTNSTPPPAPPEDGRPGGAGNASRDGRPSGGGRPRPPRPSKAPPKERKWM
LCEREAVAASYAEPLYVHCGVADNATGGARLELWFQRVGRFRSTRGDDEAVRNPFPRAPPVLLFVAQNGS
IAYRSAELGDNYIFPSPADPRNLPLTVRSLTAATEGVYTWRRDMGTKSQRKVVTVTTHRAPAVSVEPQPA
LEGAGYAAVCRAAEYYPPRSTRLHWFRNGYPVEARHARDVFTVDDSGLFSRTSVLTLEDATPTAHPPNLR
CDVSWFQSANMERRFYAAGTPAVYRPPELRVYFEGGEAVCEARCVPEGRVSLRWTVRDGIAPSRTEQTGV
CAERPGLVNLRGVRLLSTTDGPVDYTCTATGYPAPLPEFSATATYDASPGLIGSPVLVSVVAVACGLGAV
GLLLVAASCLRRKARARL

Epitope Information

IEDB Linear Epitope