VIOLIN: Vaccine Investigation and Online Information Network

fliC

General Information

Protegen ID

3979

Sequence Strain (Species/Organism)

Escherichia coli

Taxonomy ID

562

Other Database IDs

CDD:236140
CDD:279061
CDD:289230
CDD:279090

Molecule Role

Protective antigen

Molecule Role Annotation

Of the vaccine preparations, Fusion, Fusion + CT, and FimH admixed with FliC and CT showed the best protection against UPEC (Asadi et al., 2016).

References

Asadi et al., 2016: Asadi Karam MR, Habibi M, Bouzari S. Use of flagellin and cholera toxin as adjuvants in intranasal vaccination of mice to enhance protective immune responses against uropathogenic Escherichia coli antigens. Biologicals : journal of the International Association of Biological Standardization. 2016; 44(5); 378-386. [PubMed: 27461240].

Gene Information

Gene Name

fliC

Protein Information

Protein Name

FliC

NCBI Protein GI

429545217

Protein pI

4.38

Protein Weight

54849.99

Protein Length

609

Protein Note

uropathogenic strain

Protein Sequence

>AGA03821.1 FliC [Escherichia coli]
MAQVINTNSLSLITQNNINKNQSALSSSIERLSSGLRINSAKDDAAGQAIANRFTSNIKGLTQAARNAND
GISVAQTTEGALSEINNNLQRVRELTVQATTGTNSQSDLDSIQDEIKSRLDEIDRVSGQTQFNGVNVLAK
DGSMKIQVGANDGQTITIDLKKIDSSTLNLTGFNVNGSGSVANTAATKADLTAAQLSAPGAADANGTVTY
TVSAGYKESTAADVIASIKDGSAPTSAITATINNGFGDSSALTSNDYTYDPAKGDFTYDVASSANNTAAQ
VQSFLTPKAGDTANLKVTVGTTSVDVVLASDGKITAKDGSALYIDSTGNLTQNSAGLTSAKLATLTGLQG
SGVASTITTEDGTNIDIAANGNIGLTGVRISADSLQSATKSTGFTVGTGATGLTVGTDGKVTIGGTTAQS
YTSKDGSLTTDNTTKLYLQKDGSVTNGSGKAVYVEADGDFTTDAATKAATTTDPLKALDEAISQIDKFRS
SLGAIQNRLDSAVTNLNNTTTNLSEAQSRIQDADYATEVSNMSKAQIIQQAGNSVLAKANQVPQQVLSLL
QGP

Vaxign Prediction

Localization(Probability)

Extracellular
(Prob.=0.996)

Adhesin Probability

0.881

Trans-membrane Helices

Detailed Vaxign Results

Vaxign Results

Epitope Information

IEDB Linear Epitope