VIOLIN: Vaccine Investigation and Online Information Network

FimH/MrpH fusion protein

General Information

Protegen ID

3983

Sequence Strain (Species/Organism)

Escherichia coli

Taxonomy ID

32630

Other Database IDs

CDD:198456
CDD:286270
CDD:294848

Molecule Role

Protective antigen

Molecule Role Annotation

Immunization of mice with MrpH.FimH fusion with MPL or a mixture of FimH, MrpH and MPL conferred the highest protection of the bladder and kidneys when challenged with UPEC and P. mirabilis in a UTI mouse model (Habibi et al., 2015)

References

Habibi et al., 2015: Habibi M, Asadi Karam MR, Bouzari S. Evaluation of the effect of MPL and delivery route on immunogenicity and protectivity of different formulations of FimH and MrpH from uropathogenic Escherichia coli and Proteus mirabilis in a UTI mouse model. International immunopharmacology. 2015; 28(1); 70-78. [PubMed: 26033493].

Gene Information

Gene Name

FimH/MrpH fusion protein

Protein Information

Protein Name

FimH/MrpH fusion protein

NCBI Protein GI

AHW46359

Protein pI

8.73

Protein Weight

55910.91

Protein Length

644

Protein Note

Escherichia coli/Proteus mirabilis fusion

Protein Sequence

>AHW46359.1 FimH/MrpH fusion protein [synthetic construct]
MKRVITLFAVLLMGWSVNAWSFACKTANGTAIPIGGGSANVYVNLAPAVNVGQNLVVDLSTQIFCHNDYP
ETITDYVTLQRGSAYGGVLSNFSGTVKYSGSSYPFPTTSETPRVVYNSRTDKPWPVALYLTPVSSAGGVA
IKAGSLIAVLILRQTNNYNSDDFQFVWNIYANNDVVVPTGGCDVSARDVTVTLPDYPGSVPIPLTVYCAK
SQNLGYYLSGTTADAGNSIFTNTASFSPAQGVGVQLTRNGTIIPANNTVSLGAVGTSAVSLGLTANYART
GGQVTAGNVKSIIGVTFVYQMFIFKRFPAIFILIAGLFSAPAMASIFSYITESTGTPSNATYTYVIERWD
PETSGILNPCYGWPVCYVTVNHKHTVNGTGGNPAFQIARIEKLRTLAEVRDVVLKNRSFPIEGQTTHRGP
SLNSNQECVGLFYQPNSSGISPRGKLLPGSLCGIAPPPVGACKISEGAVNLNYGDIDEASLSGAKRSETI
NVTCNLAMKVLVIASGSDSGRVPLRADKSLYADLYLNNYPGEKGVTVNVPAGGSAPVSVSSTLRTNGRVA
PGRFSGSGSIILTMP

Vaxign Prediction

Localization(Probability)

Cytoplasmic Membrane
(Prob.=0.946)

Adhesin Probability

0.816

Trans-membrane Helices

Detailed Vaxign Results

Vaxign Results

Epitope Information

IEDB Linear Epitope