VIOLIN: Vaccine Investigation and Online Information Network

ompC

General Information

Protegen ID

3991

Sequence Strain (Species/Organism)

Escherichia coli

Taxonomy ID

511145

Other Database IDs

CDD:182543

Molecule Role

Protective antigen

Molecule Role Annotation

After challenge with 2.5 × 107 CFU (5 × LD50) of the highly virulent ExPEC strain PCN033, 62.5% protection was observed in mice immunized with OmpC (Liu et al., 2012).

References

Liu et al., 2012: Liu C, Chen Z, Tan C, Liu W, Xu Z, Zhou R, Chen H. Immunogenic characterization of outer membrane porins OmpC and OmpF of porcine extraintestinal pathogenic Escherichia coli. FEMS microbiology letters. 2012; 337(2); 104-111. [PubMed: 23003111].

Gene Information

Gene Name

ompC

Protein Information

Protein Name

porin OmpC

NCBI Protein GI

AYG18759

Protein pI

4.39

Protein Weight

38727.09

Protein Length

441

Protein Note

obtained from culture collection

Protein Sequence

>AYG18759.1 porin OmpC [Escherichia coli str. K-12 substr. MG1655]
MKVKVLSLLVPALLVAGAANAAEVYNKDGNKLDLYGKVDGLHYFSDNKDVDGDQTYMRLGFKGETQVTDQ
LTGYGQWEYQIQGNSAENENNSWTRVAFAGLKFQDVGSFDYGRNYGVVYDVTSWTDVLPEFGGDTYGSDN
FMQQRGNGFATYRNTDFFGLVDGLNFAVQYQGKNGNPSGEGFTSGVTNNGRDALRQNGDGVGGSITYDYE
GFGIGGAISSSKRTDAQNTAAYIGNGDRAETYTGGLKYDANNIYLAAQYTQTYNATRVGSLGWANKAQNF
EAVAQYQFDFGLRPSLAYLQSKGKNLGRGYDDEDILKYVDVGATYYFNKNMSTYVDYKINLLDDNQFTRD
AGINTDNIVALGLVYQF

Vaxign Prediction

Localization(Probability)

Outer Membrane
(Prob.=1)

Adhesin Probability

0.687

Trans-membrane Helices

Detailed Vaxign Results

Vaxign Results

Epitope Information

IEDB Linear Epitope