VIOLIN: Vaccine Investigation and Online Information Network

pmp10

General Information

Protegen ID

4033

Sequence Strain (Species/Organism)

Chlamydophila pneumoniae

Taxonomy ID

83558

Other Database IDs

CDD:273587
CDD:284879
CDD:214872

Molecule Role

Protective antigen

Molecule Role Annotation

Four of the six in vitro neutralizing antigens (Pmp2, Pmp10, OmpH-like and enolase) could inhibit Cpn dissemination in a hamster model. The results show that these Cpn proteins are immunoaccessible in infectious EBs, and recommend further investigation on their value as vaccine components.(Finco et al., 2005)

References

Finco et al., 2005: Finco O, Bonci A, Agnusdei M, Scarselli M, Petracca R, Norais N, Ferrari G, Garaguso I, Donati M, Sambri V, Cevenini R, Ratti G, Grandi G. Identification of new potential vaccine candidates against Chlamydia pneumoniae by multiple screenings. Vaccine. 2005; 23(9); 1178-1188. [PubMed: 15629361].

Gene Information

Gene Name

pmp10

Protein Information

Protein Name

Probable outer membrane protein pmp10

NCBI Protein GI

CRI40334

Protein pI

5.21

Protein Weight

93433.7

Protein Length

1016

Protein Note

Chlamydial polymorphic outer membrane protein repeat; TIGR01376

Protein Sequence

>CRI40334.1 Probable outer membrane protein pmp10 [Chlamydia pneumoniae]
MKSQFSWLVLSSTLACFTSCSTVFAATAENIGPSDSFDGSTNTGTYTPKNTTTGIDYTLTGDITLQNLGD
SAALTKGCFSDTTESLSFAGKGYSLSFLNIKSSAEGAALSVTTDKNLSLTGFSSLTFLAAPSSVITTPSG
KGAVKCGGDLTFDNNGTILFKQDYCEENGGAISTKNLSLKNSTGSISFEGNKSSATGKKGGAICATGTVD
ITNNTAPTLFSNNIAEAAGGAINSTGNCTITGNTSLVFSENSVTATAGNGGALSGDADVTISGNQSVTFS
GNQAVANGGAIYAKKLTLASGGGGGISFSNNIVQGTTAGNGGAISILAAGECSLSAEAGDITFNGNAIVA
TTPQTTKRNSIDIGSTAKITNLRAISGHSIFFYDPITANTAADSTDTLNLNKADAGNSTDYSGSIVFSGE
KLSEDEAKVADNLTSTLKQPVTLTAGNLVLKRGVTLDTKGFTQTAGSSVIMDAGTTLKASTEEVTLTGLS
IPVDSLGEGKKVVIAASAASKNVALSGPILLLDNQGNAYENHDLGKTQDFSFVQLSALGTATTTDVPAVP
TVATPTHYGYQGTWGMTWVDDTASTPKTKTATLAWTNTGYLPNPERQGPLVPNSLWGSFSDIQAIQGVIE
RSALTLCSDRGFWAAGVANFLDKDKKGEKRKYRHKSGGYAIGGAAQTCSENLISFAFCQLFGSDKDFLVA
KNHTDTYAGAFYIQHITECSGFIGCLLDKLPGSWSHKPLVLEGQLAYSHVSNDLKTKYTAYPEVKGSWGN
NAFNMMLGASSHSYPEYLHCFDTYAPYIKLNLTYIRQDSFSEKGTEGRSFDDSNLFNLSLPIGVKFEKFS
DCNDFSYDLTLSYVPDLIRNDPKCTTALVISGASWETYANNLARQALQVRAGSHYAFSPMFEVLGQFVFE
VRGSSRIYNVDLGGKFQF

Epitope Information

IEDB Linear Epitope