VIOLIN: Vaccine Investigation and Online Information Network

major outer membrane protein

General Information

Protegen ID

4038

Sequence Strain (Species/Organism)

Chlamydia trachomatis

Taxonomy ID

813

Other Database IDs

CDD:279628

Molecule Role

Protective antigen

Molecule Role Annotation

Ct MOMP multi-epitope delivered by HBcAg could be an effective vaccine for the prevention of Ct. In this study, another two epitopes were selected from the MOMP protein and tandemly linked with MOMP370-387 to enhance the immunogenicity and the protective effect of the candidate vaccine.Both the immunogenicity and the protective effect of the tandem Ct MOMP multi-epitopes were much better than that of the single epitope. Therefore, vaccines based on the tandem Ct MOMP multi-epitopes could be more effective immune prophylactics to prevent Ct infection than the single epitope in murine model system.(Jiang et al., 2017)

References

Jiang et al., 2017: Jiang P, Cai Y, Chen J, Ye X, Mao S, Zhu S, Xue X, Chen S, Zhang L. Evaluation of tandem Chlamydia trachomatis MOMP multi-epitopes vaccine in BALB/c mice model. Vaccine. 2017; 35(23); 3096-3103. [PubMed: 28456528].

Gene Information

Gene Name

major outer membrane protein

Protein Information

Protein Name

major outer membrane protein

NCBI Protein GI

AAA23141

Protein pI

5.08

Protein Weight

40217.17

Protein Length

468

Protein Note

Chlamydia major outer membrane protein; pfam01308

Protein Sequence

>AAA23141.1 major outer membrane protein [Chlamydia trachomatis]
MKKLLKSVLVFAALSSASSLQALPVGNPAEPSLMIDGILWEGFGGDPCDPCTTWCDAISMRMGYYGDFVF
DRVLKTDVNKEFQMGAAPTTRDVAGLEKDPVVNVARPNPAYGKHMQDAEMFTNAAYMALNIWDRFDVFCT
LGATTGYLKGNSASFNLVGLFGTKTQSSGFDTANIVPNTALNQAVVELYTDTTFAWSVGARAALWECGCA
TLGASFQYAQSKPKVEELNVLCNASEFTINKPKGYVGAEFPLDITAGTEAATGTKDASIDYHEWQASLAL
SYRLNMFTPYIGVKWSRVSFDADTIRIAQPKLAKPVLDTTTLNPTIAGKGTVVSSAENELADTMQIVSLQ
LNKMKSRKSCGIAVGTTIVDADKYAVTVETRLIDERAAHVNAQFRF

Epitope Information

IEDB Linear Epitope