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fspA2

General Information
Protegen ID 409
Sequence Strain (Species/Organism) Campylobacter jejuni
VO ID VO_0011049
Taxonomy ID 197
Molecule Role Protective antigen
Molecule Role Annotation Immunogenicity and protective efficacy of three Campylobacter jejuni flagellum-secreted proteins, FlaC, FspA1, and FspA2, were compared by use of a mouse model. Immunization with FspA2 provided 38.4% (without adjuvant) or 47.2% (with adjuvant) protection against disease from homologous challenge with CG8486 (Baqar et al., 2008).
Related Vaccines(s) C. jejuni FspA2 protein vaccine
References
Baqar et al., 2008: Baqar S, Applebee LA, Gilliland TC Jr, Lee LH, Porter CK, Guerry P. Immunogenicity and protective efficacy of recombinant Campylobacter jejuni flagellum-secreted proteins in mice. Infection and immunity. 2008; 76(7); 3170-3175. [PubMed: 18426878].
Gene Information
Gene Name fspA2
Protein Information
Protein Name FspA2
NCBI Protein GI 116292677
Protein pI 5.78
Protein Weight 15654.3
Protein Length 187
Protein Note sigma 28 regulated; Campylobacter jejuni-specific virulence factor that is secreted through the flagella filament
Protein Sequence 
>ABJ97654.1 FspA2 [Campylobacter jejuni]
MKIDTLTKNFSNYQTQINKNNDLASNVHSDNVVKIQISDEARSLSQANSKNEKEYEIKVSQEKIENHKDQ
NSIQSSKGGGNPALEALIAKLAEILAKIAELTQKMTNANEQMKTTFQKQIDVLISQADVIQAQIQELQSQ
QA
Epitope Information
IEDB Linear Epitope