VIOLIN: Vaccine Investigation and Online Information Network

hbpA

General Information

Protegen ID

4090

Sequence Strain (Species/Organism)

Actinobacillus pleuropneumoniae

Taxonomy ID

416269

Other Database IDs

CDD:223818
CDD:173858

Molecule Role

Protective antigen

Molecule Role Annotation

Three of these proteins (APJL_0126, HbpA and OmpW) were further tested in the natural host (swine) by homologous and heterologous challenges. The results showed that these proteins could induce high titers of antibodies(Chen et al., 2012)

Related Vaccines(s)

A. pleuropneumoniae HbpA vaccine

References

Chen et al., 2012: Chen X, Xu Z, Li L, Chen H, Zhou R. Identification of conserved surface proteins as novel antigenic vaccine candidates of Actinobacillus pleuropneumoniae. Journal of microbiology (Seoul, Korea). 2012; 50(6); 978-986. [PubMed: 23274984].

Gene Information

Gene Name

hbpA

Protein Information

Protein Name

Heme-binding protein A

NCBI Protein GI

ABN75084

Protein pI

6.89

Protein Weight

57811.6

Protein Length

643

Protein Note

ABC-type transport system, periplasmic component [Amino acid transport and metabolism]; COG0747

Protein Sequence

>ABN75084.1 Heme-binding protein A [Actinobacillus pleuropneumoniae serovar 5b str. L20]
MKLANLTKVSAAVLAVLALAACDDKNADGKTTAKPAAEKTFVNCVSRSPQYFSPALAMDGISYNASSQQV
YNRLVEFKRGSTEIEPALAESWDISEDGLTYTFHLRKGVKFHSNKEFTPSRDFNADDVVFSFNRQLDPNH
PYHTVSKATYPYFKAMKFPTLLKSVEKVDDHTVKFTLTKRDATFVSSLGMDFTSIYSAEYADAMLKAGKP
ETIDTTPIGTGPFAFTGYVLDQASRYVAYKDYWKGKADFDRLIFEIVPDATARYAKLQAGQCDLIDFPNA
TDIEKMKTDPKVQLLSQPGLNIAYVAFNTEKAPFDNVKVRQALNLAVDKKAIIDVVYQGAGIAAKNPLPP
TIWGYNDSLAESEFNIEKAKQLLAEAGYPNGFETELWVQPVVRASNPNPRRMSEIIQADWAKIGVKAKLV
TYEWGDYIKRTKAGELTAGTYGWSGDNGDPDNFLSPLFGSANVGNSNYARFNSPELDALLDKALGLSDKA
ERTKLYEQAQALLREQAPWINVAHSINFAPTSKRVQDYKQSPFGYTYLYGTKLAD

Epitope Information

IEDB Linear Epitope