VIOLIN: Vaccine Investigation and Online Information Network

tfbA

General Information

Protegen ID

4093

Sequence Strain (Species/Organism)

Actinobacillus pleuropneumoniae

Taxonomy ID

715

Other Database IDs

CDD:279621

Molecule Role

Protective antigen

Molecule Role Annotation

Immunoblots of iron-restricted profiles detected PotD2, heme-binding protein A (HbpA), and capsule polysaccharide export protein (CpxD) as well as surface antigens TbpA, TbpB, and OmlA. These data identify OM proteins that demonstrate immunogenicity and upregulation under conditions mimicking infection.(Chung et al., 2012)

References

Chung et al., 2012: Chung JW, Küster-Schöck E, Gibbs BF, Jacques M, Coulton JW. Immunoproteomic analyses of outer membrane antigens of Actinobacillus pleuropneumoniae grown under iron-restricted conditions. Veterinary microbiology. 2012; 159(1-2); 187-194. [PubMed: 22541161].

Gene Information

Gene Name

tfbA

Protein Information

Protein Name

transferrin-binding protein

NCBI Protein GI

AAA21929

Protein pI

7.6

Protein Weight

56362.89

Protein Length

630

Protein Note

Transferrin binding protein-like solute binding protein; pfam01298

Protein Sequence

>AAA21929.1 transferrin-binding protein [Actinobacillus pleuropneumoniae]
MHFKLNPYALAFTSLFLVACSGGKGSFDLEDVRPNKTTGVSKEEYKDVETAKKEKEQLGELMEPALGYVV
KVPVSSFENKKVDISDIEVITNGNLDDVPYKANSSKYNYPDIKTKDSSLQYVRSGYVIDGEHSGSNEKGY
VYYKGNSPAKELPVNQLLTYTGSWDFTSNANLNNEEGRPNYLNDDYYTKFIGKRVGLVSGDAKPAKHKYT
SQFEVDFATKKMTGKLSDKEKTIYTVNADIRGNRFTGAATASDKNKGKGESYNFFSADSQSLEGGFYGPK
AEEMAGKFVANDKSLFAVFSAKHNGSNVNTVRIIDASKIDLTNFSISELNNFGDASVLIIDGKKIKLAGS
GFTNKHTIEINGKTMVAVACCSNLEYMKFGQLWQQAEGGKPENNSLFLQGERTATDKMPKGGNYKYIGTW
DAQVSKENNWVATADDDRKAGYRTEFDVDFGNKNLSGKLFDKNGVNPVFTVDAKIDGNGFTGKAKTSDEG
FALDSGSSRYENVKFNDVAVSGGFYGPTAAELGGQFHHKSENGSVGAVFGAKQQVKK

Epitope Information

IEDB Linear Epitope