VIOLIN: Vaccine Investigation and Online Information Network

mrp

General Information

Protegen ID

4102

Sequence Strain (Species/Organism)

Streptococcus pyogenes

Taxonomy ID

1314

Other Database IDs

CDD:273479
CDD:309295
CDD:330553
CDD:307064

Molecule Role

Protective antigen

Molecule Role Annotation

(Courtney et al., 2017; Dale et al., 2015)

References

Courtney et al., 2017: Courtney HS, Niedermeyer SE, Penfound TA, Hohn CM, Greeley A, Dale JB. Trivalent M-related protein as a component of next generation group A streptococcal vaccines. Clinical and experimental vaccine research. 2017; 6(1); 45-49. [PubMed: 28168173].

Dale et al., 2015: Dale JB, Niedermeyer SE, Agbaosi T, Hysmith ND, Penfound TA, Hohn CM, Pullen M, Bright MI, Murrell DS, Shenep LE, Courtney HS. Protective immunogenicity of group A streptococcal M-related proteins. Clinical and vaccine immunology : CVI. 2015; 22(3); 344-350. [PubMed: 25630406].

Gene Information

Gene Name

mrp

Protein Information

Protein Name

Emm-related protein Mrp

NCBI Protein GI

ANC26187

Protein pI

9.54

Protein Weight

45693.37

Protein Length

494

Protein Note

Gram-positive signal peptide, YSIRK family; TIGR01168

Protein Sequence

>ANC26187.1 Emm-related protein Mrp [Streptococcus pyogenes]
MSKRNPNKHYSLRKLKTGTASVAVALTVLGTGLANTTDVKAETVGRFSDEQVRKAREKAIEDVFDGYTGA
RSVYQSGNLPNRLTPTKLSKLMQQMYKETLQKKEELDTLSKALTHTIEKKIESENAYKKELGQLKAAAEA
EAQKALDALNNKNKQISDLTNENAQLKEAIEGYVQTIQNASREIAAKQQELAAAKSQLEAKNAEIEALKQ
QDASKTEEIAKLQSEAATLENLLGSAKRELTELQAKLDTATAEKAKLESQVTTLENLLGSAKRELTDLQA
KLDAANAEKEKLQSQAAALEKQLEATKKELADLQAKLAATNQEKEKLEAEAKALKEQLAKQAEELAKLKA
DKASGAQKPDTKPGNKEVPTRPSQTRTNTNKAPMAQTKRQLPSTGEETTNPFFTAAALTVIASAGVLALK
RKEEN

Epitope Information

IEDB Linear Epitope