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Env/Rex/Tax

General Information
Protegen ID 411
Sequence Strain (Species/Organism) Bovine leukemia virus
VO ID VO_0011051
Taxonomy ID 11901
Molecule Role Protective antigen
Molecule Role Annotation The bovine leukemia virus (BLV) envelope gene encoding extracellular glycoprotein gp51 (encoded by env gene) and transmembrane glycoprotein gp30 was cloned into a vehicle expression vector under the human cytomegalovirus (CMV) intermediate early promoter. The intramuscular injection of this plasmid vector generated a cellular immune response. Seven out of ten cows vaccinated with the DNA construct resisted a drastic challenge (Brillowska et al., 1999).
Related Vaccines(s) Bovine leukemia virus DNA vaccine encoding Env
References
Brillowska et al., 1999: Brillowska A, Dabrowski S, Rułka J, Kubiś P, Buzała E, Kur J. Protection of cattle against bovine leukemia virus (BLV) infection could be attained by DNA vaccination. Acta biochimica Polonica. 1999; 46(4); 971-976. [PubMed: 10824867].
Gene Information
Gene Name Env/Rex/Tax
NCBI Gene ID 2760849
Genbank Accession AF033818
Locus Tag BLVgp05
Gene Starting Position 4614
Gene Ending Position 7460
DNA Sequence 
>NC_001414.1:4614-7460 Bovine leukemia virus, complete genome
AATGCCCAAAGAACGACGGTCCCGAAGACGCCCACAACCGATCATCAGATGGGTAAGTCTCACTCTTACT
CTCCTCGCTCTCTGTCAGCCCATCCAGACTTGGAGATGCTCCCTGTCCCTAGGAAATCAACAATGGATGA
CAACATATAACCAAGAGGCAAAATTTTCCATCTCCATTGACCAAATATTAGAGGCTCACAATCAATCACC
TTTCTGTCCCAGGTCTCCCAGATACACCTTGGACTTCGTAAATGGTTATCCTAAGATCTATTGGCCCCCC
CCACAAGGGCGGCGCCGGTTTGGAGCCAGGGCCATGGTCACATATGATTGCGAGCCCCGATGCCCTTATG
TGGGGGCAGATCACTTCGACTGCCCCCACTGGGACAATGCCTCCCAGGCCGATCAAGGGTCCTTTTATGT
CAATCATCAGATTTTATTCCTGCATCTCAAACAATGTCATGGAATTTTCACTCTAACCTGGGAAATATGG
GGATATGATCCCCTGATCACCTTTTCTTTACATAAAATTCCTGATCCCCCTCAACCCGACTTCCCTCAGC
TGAACAGTGACTGGGTTCCCTCTGTCAGATCATGGGCCCTGCTTTTAAATCAAACGGCACGGGCCTTCCC
AGACTGTGCTATATGTTGGGAACCTTCCCCTCCCTGGGCTCCCGAAATATTAGTATATAACAAAACCATC
TCCGGCTCTGGACCCGGTCTCGCCCTCCCGGACGCCCAAATCTTCTGGGTCAACACGTCCTTGTTTAACA
CCACCCAAGGATGGCACCACCCTTCCCAGAGGTTGTTGTTCAATGTTTCTCAAGGCAACGCCTTATTATT
ACCCCCTATCTCCCTGGTTAATCTCTCTACGGTTTCCTCCGCCCCTCCTACCCGGGTCAGACGCAGTCCC
GTCGCAGCCCTGACCTTAGGCCTAGCCCTGTCAGTGGGGCTCACTGGAATTAATGTAGCCGTGTCTGCCC
TTAGCCATCAGAGACTCACCTCCCTGATCCACGTTCTGGAGCAAGATCAGCAACGCTTGATCACAGCAAT
TAACCAGACCCATTATAATTTGCTTAATGTGGCCTCTGTGGTCGCCCAGAACCGACGGGGGCTTGATTGG
TTGTACATCCGGCTGGGTTTTCAAAGCCTATGTCCCACAATCAATGAACCTTGCTGTTTCCTACGCATTC
AAAATGACTCCATTATCCGCCTCGGTGATCTCCAGCCTCTCTCGCAAAGAGTCTCTACAGACTGGCAGTG
GCCCTGGAATTGGGATCTGGGGCTCACCGCCTGGGTGCGAGAAACCATTCATTCTGTTCTAAGCCTATTC
CTATTAGCCCTTTTTTTGCTCTTCTTGGCCCCCTGCCTGATAAAATGCTTGACCTCTCGCCTTTTAAAAC
TCCTCCGGCAGGCTCCCCACTTCCCTGAAATCTCCTTCCCCCCTAAACCCGATTCTGATTATCAGGCCTT
GCTACCGTCAGCACCAGAGATCTACTCTCACCTCTCCCCCACCAAACCCGATTACATCAACCTTCGACCC
TGCCCTTGACACCCCCGTGTTTCACGCACCCTCAGGCTGTGGTGGGGCACTGGCTTAGTGGAATAGTCAG
TGTACCATCACAAGCCTCTTCTTGCTGCCAGCACCGAGTTCGAACACAGCCCTACCCTGAGCCTCTCTGA
GTACATGACTGAGTGTAGCGCAGAGAGGTTGTCGCTTCTGCGTGTCACTCAGTCATTTTTTATAGCCGAT
TGGGGTTCGCGCCCTCCCATTGCCTGTGACACGGTTAAGACCTCTCTCACTTCTGCTTCACCATCCCCCT
GCCAGCGTTGGTCTAGTGGAAAGAACTAACGCTGACGGGGGCGATTTCTTGCAGCTGTGCTAAGCGAGAG
GCTCTGGTGCTGGGGATAAGATGCGGCCCCTAGCACCACAGTCTCTGCGCCTTTTGGGTTCGAATCTTCC
CCATGCAGCTTCCGCTTTTTACGCCCTGTTGCACACCCTTTCTAGAGATACCTGAAAATCTCAGCTCGCA
CCCCAAGGAAGGTTGTGGCTCAGAGGTTAAAATAGCTCGGACCGCAACCTCCCTTTCTTTTTATTCCACC
CTCGCAAGGCCCCGGGTTCTGGGCCCCCTAACGGAGGTTCAGAATTTCCTCTACTAGGGGATGCTCAGGT
CCAAGTGTGCACAATATCTCTTCCAAAAGGTCCTGATGAACATCTTCCCATGTAACAAGCCCCAGCAGAG
ACATTCCAGCCACATCCAGCAGCATTTGGGCCGCCTTCTCTAACAGTGCCCATAAAGTCCCTTCCGTTTC
CACAACGGCTGCCTCTGCATCTTCTATTTCCACCTCGGCACCGACTCCCCCGCCGAGCCCTTCAAGCTCT
TCGGGATCCATTACCTGATAACGACAAAATTATTTCTTGTCTTTTAAGCAAGTGTTGTTGGTTGGGGGCC
CCACTCTCTACATGCCTGCCCGGCCCTGGTTTTGTCCAATGATGTCACCATCGATGCCTGGTGCCCCCTC
TGCGGGCCCCATGAACGACTCCAATTCGAAAGGATCGACACCACGCTCACCTGCGAGACCCACCGTATCA
CCTGGACCGCCGATGGACGACCTTTTGGCCTCAATGGAACATTGTTCCCTCGACTGCATGTCTCCGAGAC
CCGCCCCCAAGGGCCCCGACGACTCTGGATCAACTGCCCCCTTCCGGCCGTTCGCGCTCAGCCCGGCCCG
GTTTCACTTTCCCCCTTCGAGCAGTCCCCCTTCCAGCCCTACCAATGCCAATTGCCCTCGGCCTCTAGCG
ACGGTTGCCCCATCATCGGGCACGGCCTTCTTCCCTGGAACAACTTA
Protein Information
Protein Name p18
NCBI Protein GI 9626230
Protein Accession NP_056898
Protein pI 10.96
Protein Weight 16183.28
Protein Length 156
Protein Sequence 
>NP_056898.1 p18 [Bovine leukemia virus]
MPKERRSRRRPQPIIRWQVLLVGGPTLYMPARPWFCPMMSPSMPGAPSAGPMNDSNSKGSTPRSPARPTV
SPGPPMDDLLASMEHCSLDCMSPRPAPKGPDDSGSTAPFRPFALSPARFHFPPSSSPPSSPTNANCPRPL
ATVAPSSGTAFFPGTT
Epitope Information
IEDB Linear Epitope