VIOLIN: Vaccine Investigation and Online Information Network

spa

General Information

Protegen ID

4113

Sequence Strain (Species/Organism)

Streptococcus pyogenes

Taxonomy ID

1314

Other Database IDs

CDD:288951
CDD:287215

Molecule Role

Protective antigen

Molecule Role Annotation

(McNeil et al., 2005)

References

McNeil et al., 2005: McNeil SA, Halperin SA, Langley JM, Smith B, Warren A, Sharratt GP, Baxendale DM, Reddish MA, Hu MC, Stroop SD, Linden J, Fries LF, Vink PE, Dale JB. Safety and immunogenicity of 26-valent group a streptococcus vaccine in healthy adult volunteers. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2005; 41(8); 1114-1122. [PubMed: 16163629].

Gene Information

Gene Name

spa

Protein Information

Protein Name

Spa

NCBI Protein GI

AIG88580

Protein pI

4.97

Protein Weight

55020.08

Protein Length

605

Protein Note

RNA polymerase recycling family C-terminal; pfam12137

Protein Sequence

>AIG88580.1 Spa, partial [Streptococcus pyogenes]
TRIAQAVTAAVLMGTAVTTVGGALGTTTTVKAYQINQDDLSKLTEAIVNKEMIRHGGGKSQSDIIKDVKS
ILSEAKVETLQTLLQGFDSTSPGYAEGLTYLGNLTNRLGSFNTGLDGASSAEAYHGYLTDLRRMVVEEVQ
SRVASEAELKTKLAEKEKVAERLGEELTKVIKLKSDIELNAKKAQGELTKTKQQLEEALAKSEELSTDLL
SAQKERDTAFKVSKELADKLAESEKGKANALKVSKELADKLATAESGRDKALAISAELANKLAAKTAEAE
ELLNNVDSFGRLVESAKREMQEKLAEIEALKAEKAQADAALETANATIAGLQAEVEKVKSDLANANQLVE
AGKRDLADLAKAKAEADAALATSEAKVAKLEKAKAEADAKVTELEAAVTAAKEEVAKVKAELETVTKELE
TVKAEKAALEAEITDLKKQHAEKVAELEAAIKRLEEELAAKIKEFEALENTSKEEKANFQKEIDRLKAEL
AAKIKDLTKAGSSVATGTASTGVASSKAQLPSTGEATHPFFTAAALAVMAGAGVMA

Epitope Information

IEDB Linear Epitope