VIOLIN: Vaccine Investigation and Online Information Network

isp2

General Information

Protegen ID

4119

Sequence Strain (Species/Organism)

Streptococcus pyogenes

Taxonomy ID

160490

Other Database IDs

CDD:330579
CDD:226451

Molecule Role

Protective antigen

Molecule Role Annotation

(Mortensen et al., 2016)

References

Mortensen et al., 2016: Mortensen R, Nissen TN, Fredslund S, Rosenkrands I, Christensen JP, Andersen P, Dietrich J. Identifying protective Streptococcus pyogenes vaccine antigens recognized by both B and T cells in human adults and children. Scientific reports. 2016; 6; 22030. [PubMed: 26911649].

Gene Information

Gene Name

isp2

Protein Information

Protein Name

immunogenic secreted precursor-like protein

NCBI Protein GI

NP_269810

Protein pI

6.13

Protein Weight

52821.45

Protein Length

601

Protein Note

Domain of unknown function (DUF4775); cl25758

Protein Sequence

>NP_269810.1 immunogenic secreted precursor-like protein [Streptococcus pyogenes M1 GAS]
MNKNKLLRVAMLLSLLAPTAESMTVLAQDVMLETHKATTNETSDSSSKEENNKNAAPTTSDKTDQGPLDA
SAETNSNSLVNADDKKRSDSSQSAIGSSDNKAEAENQVDDKSTDHSKSTDHSKPTDQPKPSPSKVDTAPA
SSLSKQLPEARTPIQSLSPYVSDLDLSEIDIPSVNTYAAYVEHWSGKNAYTHHLLSRRYGIKADQIDSYL
KSTGIAYDSTRINGEKLLQWEKKSGLDVRAIVAIAMSESSLGTQGIATLLGANMFGYAAFDLDPTQASKF
NDDSAIVKMTQDTIIKNKNSNFALQDLKAAKFSRGQLNFASDGGVYFTDTTGSGKRRAQIMEDLDKWIDD
HGGTPAIPAELKVQSSASFASVPAGYKLSKSYDVLGYQASSYAWGQCTWYVYNRAKELGYQFDPFMGNGG
DWKYKVGYALSKTPKVGYAISFAPGQAGADGTYGHVSIVEDVRKDGSILISESNCIGLGKISYRTFTAQQ
AEQLTYVIGKSKN

Epitope Information

IEDB Linear Epitope