VIOLIN: Vaccine Investigation and Online Information Network

nuclease

General Information

Protegen ID

4125

Sequence Strain (Species/Organism)

Streptococcus pyogenes

Taxonomy ID

1314

Other Database IDs

CDD:225249

Molecule Role

Protective antigen

Molecule Role Annotation

(Radcliff et al., 2015)

References

Radcliff et al., 2015: Radcliff FJ, Fraser JD, Proft T. Vaccination with Streptococcus pyogenes nuclease A stimulates a high antibody response but no protective immunity in a mouse model of infection. Medical microbiology and immunology. 2015; 204(2); 185-191. [PubMed: 25119670].

Gene Information

Gene Name

nuclease

Protein Information

Protein Name

nuclease

NCBI Protein GI

ASQ22678

Protein pI

7.01

Protein Weight

92218.78

Protein Length

970

Protein Note

genotype: emm75

Protein Sequence

>ASQ22678.1 nuclease [Streptococcus pyogenes]
MINKKCIISVSLLTLAITLTSVEEVTSRQNLTYANEIVTQRPKRESVISDKSNFPVISPYLASVDFGERK
TPLPTPDKGVKVTTEQSIAQVRKGPEERTYTVTGKITSVINGWGGYGFYIQDSEGIGLYVYPQKDLGYSK
GDIVQLTGTLTRFKGDLQLQQVTAHKKLELSFPTSVKEAVISELETTTPSTLVKLSHVTVGELSTDQYNN
TSFLVRDDSGKSIVVHIDHRTGVKGADVVTKISQGDLINLTAILSIVDGQLQLRPFSLEQLEVVKKVTSS
NSDASSRNIVKIGEIQGASHTSPLLKKAVTVEQVVVTYLDDSTHFYVQDLNGDGDLATSDGIRVFAKNAK
VQVGDVLTISGEVEEFFGRGYEERKQTDLTITQIVAKAVTKTGTAQVPSPLVLGKDRIAPANIIDNDGLR
VFDPEEDAIDYWESMEGMLVAVDDAKILGPMKNKEIYVLPGSSTRPLNNSGGVLLPANSYNTDVIPVLFK
KGKQIIKAGDSYKGRLAGPVSYSYGNYKVFVDDSKNMPSLMDGHLKPEKTNLQKDLSKLSIASYNIENFS
ANPSSTKDEKVKRIAESFIRDLNAPDIIGLIEVQDNNGPTDDGTTDATQSAQRLIDAIKKLGGPTYRYVD
IAPENNVDGGQPGGNIRTGFLYQPERVSLSDKPKGGARDALTWVNGELNLSVGRIDPTNAAWKDVRKSLA
AEFIFQGRKVVVVANHLNSKRGDNALYGRVQPVTFKSEQRRHVLANMLAQFAKEGAKHQANIVMLGDFND
FEFTKTIQLIEEGDMVNLVSRHDISDRYSYFHQGNNQTLDNILVSRHLLDHYEFDMVHVNSPFMEAHGRA
SDHDPLLLQLSFPKENDKAESSKQSVKAKKTSKGKLLPKTGDSLVYVITLLGTASLLVPILLLTKGKKES

Epitope Information

IEDB Linear Epitope