VIOLIN: Vaccine Investigation and Online Information Network

slo

General Information

Protegen ID

4131

Sequence Strain (Species/Organism)

Streptococcus pyogenes

Taxonomy ID

160490

Other Database IDs

CDD:307453

Molecule Role

Protective antigen

Molecule Role Annotation

(Bensi et al., 2012)

References

Bensi et al., 2012: Bensi G, Mora M, Tuscano G, Biagini M, Chiarot E, Bombaci M, Capo S, Falugi F, Manetti AG, Donato P, Swennen E, Gallotta M, Garibaldi M, Pinto V, Chiappini N, Musser JM, Janulczyk R, Mariani M, Scarselli M, Telford JL, Grifantini R, Norais N, Margarit I, Grandi G. Multi high-throughput approach for highly selective identification of vaccine candidates: the Group A Streptococcus case. Molecular & cellular proteomics : MCP. 2012; 11(6); M111.015693. [PubMed: 22286755].

Gene Information

Gene Name

slo

Protein Information

Protein Name

streptolysin O precursor

NCBI Protein GI

NP_268546

Protein pI

8.23

Protein Weight

60115.22

Protein Length

651

Protein Note

Thiol-activated cytolysin; pfam01289

Protein Sequence

>NP_268546.1 streptolysin O precursor [Streptococcus pyogenes M1 GAS]
MSNKKTFKKYSRVAGLLTAALIIGNLVTANAESNKQNTASTETTTTNEQPKPESSELTTEKAGQKTDDML
NSNDMIKLAPKEMPLESAEKEEKKSEDKKKSEEDHTEEINDKIYSLNYNELEVLAKNGETIENFVPKEGV
KKADKFIVIERKKKNINTTPVDISIIDSVTDRTYPAALQLANKGFTENKPDAVVTKRNPQKIHIDLPGMG
DKATVEVNDPTYANVSTAIDNLVNQWHDNYSGGNTLPARTQYTESMVYSKSQIEAALNVNSKILDGTLGI
DFKSISKGEKKVMIAAYKQIFYTVSANLPNNPADVFDKSVTFKELQRKGVSNEAPPLFVSNVAYGRTVFV
KLETSSKSNDVEAAFSAALKGTDVKTNGKYSDILENSSFTAVVLGGDAAEHNKVVTKDFDVIRNVIKDNA
TFSRKNPAYPISYTSVFLKNNKIAGVNNRTEYVETTSTEYTSGKINLSHQGAYVAQYEILWDEINYDDKG
KEVITKRRWDNNWYSKTSPFSTVIPLGANSRNIRIMARECTGLAWEWWRKVIDERDVKLSKEINVNISGS
TLSPYGSITYK

Epitope Information

IEDB Linear Epitope

IEDB ID	Epitope	Starting position	Ending position
11269	ECTGLAWEWWR	529	540
136058	DKATV	211	216
178366	WEWWR	535	540
514720	EINYDDKGKEVITKR	483	498
518820	ILWDEINYDDKGKEV	479	494
522340	LWDEINYDDKGKEVI	480	495
515309	ESAEKEEKKSEDKKK	86	101
522523	MPLESAEKEEKKSED	83	98
523652	PLESAEKEEKKSEDK	84	99
521052	LESAEKEEKKSEDKK	85	100
519721	KEMPLESAEKEEKKS	81	96
514956	EMPLESAEKEEKKSE	82	97
511023	AGQKTDDMLNSNDMI	62	77
517322	GQKTDDMLNSNDMIK	63	78
524254	QKTDDMLNSNDMIKL	64	79
523622	PKEMPLESAEKEEKK	80	95
514762	EKAGQKTDDMLNSND	60	75
519501	KAGQKTDDMLNSNDM	61	76
515247	EQPKPESSELTTEKA	48	63
526324	SNKQNTASTETTTTN	33	48
522919	NKQNTASTETTTTNE	34	49
520273	KQNTASTETTTTNEQ	35	50
524334	QNTASTETTTTNEQP	36	51
523280	NTASTETTTTNEQPK	37	52
527217	TASTETTTTNEQPKP	38	53
512105	ASTETTTTNEQPKPE	39	54
527007	STETTTTNEQPKPES	40	55
527334	TETTTTNEQPKPESS	41	56
511370	ANAESNKQNTASTET	29	44
522634	NAESNKQNTASTETT	30	45
510889	AESNKQNTASTETTT	31	46
515342	ESNKQNTASTETTTT	32	47
522736	NEQPKPESSELTTEK	47	62
521517	LNSNDMIKLAPKEMP	70	85
529846	WDEINYDDKGKEVIT	481	496
512634	DEINYDDKGKEVITK	482	497
518909	INYDDKGKEVITKRR	484	499
523377	NYDDKGKEVITKRRW	485	500
530071	YDDKGKEVITKRRWD	486	501
522493	MLNSNDMIKLAPKEM	69	84
519680	KEEKKSEDKKKSEED	90	105
512556	DDMLNSNDMIKLAPK	67	82
513268	DMLNSNDMIKLAPKE	68	83
515353	ESSELTTEKAGQKTD	53	68
523265	NSNDMIKLAPKEMPL	71	86
526901	SSELTTEKAGQKTDD	54	69
527240	TDDMLNSNDMIKLAP	66	81
525593	SAEKEEKKSEDKKKS	87	102
510858	AEKEEKKSEDKKKSE	88	103
514781	EKEEKKSEDKKKSEE	89	104
520490	KTDDMLNSNDMIKLA	65	80
524376	QPKPESSELTTEKAG	49	64
523627	PKPESSELTTEKAGQ	50	65
520141	KPESSELTTEKAGQK	51	66
523512	PESSELTTEKAGQKT	52	67
523888	PVDISIIDSVTDRTY	160	175
523307	NTTPVDISIIDSVTD	157	172
528242	TTPVDISIIDSVTDR	158	173
527995	TPVDISIIDSVTDRT	159	174
511576	APKEMPLESAEKEEK	79	94
520771	LAPKEMPLESAEKEE	78	93
519442	IYSLNYNELEVLAKN	113	128
527303	TEKAGQKTDDMLNSN	59	74
520004	KLAPKEMPLESAEKE	77	92
518840	INDKIYSLNYNELEV	109	124
522681	NDKIYSLNYNELEVL	110	125
513051	DKIYSLNYNELEVLA	111	126
519927	KIYSLNYNELEVLAK	112	127
528208	TTEKAGQKTDDMLNS	58	73
518739	IKLAPKEMPLESAEK	76	91
528255	TTTNEQPKPESSELT	44	59
528234	TTNEQPKPESSELTT	45	60
527727	TNEQPKPESSELTTE	46	61
513265	DMIKLAPKEMPLESA	74	89
525845	SELTTEKAGQKTDDM	55	70
522467	MIKLAPKEMPLESAE	75	90
514938	ELTTEKAGQKTDDML	56	71
522219	LTTEKAGQKTDDMLN	57	72
515434	ETTTTNEQPKPESSE	42	57
528256	TTTTNEQPKPESSEL	43	58
526311	SNDMIKLAPKEMPLE	72	87
522686	NDMIKLAPKEMPLES	73	88