VIOLIN: Vaccine Investigation and Online Information Network

fbp54

General Information

Protegen ID

4152

Sequence Strain (Species/Organism)

Streptococcus pyogenes

Taxonomy ID

1314

Other Database IDs

CDD:224212
CDD:283353

Molecule Role

Protective antigen

Molecule Role Annotation

(Kawabata et al., 2001)

Related Vaccines(s)

S. pyogenes FBP54 Protein Vaccine

References

Kawabata et al., 2001: Kawabata S, Kunitomo E, Terao Y, Nakagawa I, Kikuchi K, Totsuka K, Hamada S. Systemic and mucosal immunizations with fibronectin-binding protein FBP54 induce protective immune responses against Streptococcus pyogenes challenge in mice. Infection and immunity. 2001; 69(2); 924-930. [PubMed: 11159987].

Gene Information

Gene Name

fbp54

Protein Information

Protein Name

fibronectin/fibrinogen-binding protein

NCBI Protein GI

AAR18990

Protein pI

8.52

Protein Weight

52434.05

Protein Length

567

Protein Note

Predicted component of the ribosome quality control (RQC) complex, YloA/Tae2 family, contains fibronectin-binding (FbpA) and DUF814 domains [Translation, ribosomal structure and biogenesis]; COG1293

Protein Sequence

>AAR18990.1 fibronectin/fibrinogen-binding protein, partial [Streptococcus pyogenes]
MIMRKYLQGAVIEQLEQIDNDRIIEIKVSNKNEIGDAIQATLIIEIMGKHSNIILVDRAENKIIESIKHV
GFSQNSYRTILPGSTYIEPPKTAAVNPFTITDVPLFEILQTQELTVKSLQQHFQGLGRDTAKELAELLTT
DKLKRFREFFARPTQANLTTASFAPVLFSDSHATFETLSDMLDHFYQDKAERDRINQQASDLIHRVQTEL
DKNRNKLSKQEAELLATENAELFRQKGELLTTYLSMVPNNQDSVVLDNYYTGEKLEIALDKALTPNQNAQ
RYFKKYQKLKEAVKHLSGLIADTKQSITYFESVDYNLSQASIDDIEDIREELYQAGFLKSRQRDKRHKRK
KPEQYLASDGKTILMVGRNNLQNEELTFKMAKKGELWFHAKDIPGSHVIIKDNLDPSDEVKTDAAELAAY
YSKARLSNLVQVDMIEAKKLHKPSGAKPGFVTYTGQKTLRVTPDQAKILSMKLF

Epitope Information

IEDB Linear Epitope