VIOLIN: Vaccine Investigation and Online Information Network

pcpA

General Information

Protegen ID

4155

Sequence Strain (Species/Organism)

Streptococcus pneumoniae

Taxonomy ID

1313

Other Database IDs

CDD:315882
CDD:275383
CDD:227588

Molecule Role

Protective antigen

Molecule Role Annotation

Vaccination with PcpA significantly reduced the bacterial burdens in MEF at both 24 (p=0.02) and 48hpi (p=0.004)(Xu et al., 2017)

References

Xu et al., 2017: Xu Q, Pryharski K, Pichichero ME. Trivalent pneumococcal protein vaccine protects against experimental acute otitis media caused by Streptococcus pneumoniae in an infant murine model. Vaccine. 2017; 35(2); 337-344. [PubMed: 27919628].

Gene Information

Gene Name

pcpA

Protein Information

Protein Name

choline-binding protein PcpA

NCBI Protein GI

WP_130894716

Protein pI

7.18

Protein Weight

65803.48

Protein Length

703

Protein Note

Leucine rich repeats (6 copies); pfam13306

Protein Sequence

>WP_130894716.1 choline-binding protein PcpA [Streptococcus pneumoniae]
MKKTTILSLTTAAVILAAYVPNEPILADTPSSEVIKETKVGSIIQQNNIKYKVLTVEGNIGTVQVGNGVT
PVEFEAGQDGKPFTIPTKITVGDKVFTVTEVASQAFSYYPDETGRIVYYPSSITIPSSIKKIQKKGFHGS
KAKTIIFDKGSQLEKIEDRAFDFSELEEIELPASLEYIGTSAFSFSQKLKKLTFSSSSKLELISHEAFAN
LSNLEKLTLPKSVKTLGSNLFRLTTSLKHVDVEEGNESFASVDGVLFSKDKTQLIYYPSQKNDESYKTPK
ETKELASYSFNKNSYLKKLELNEGLEKIGTFAFADAIKLEEISLPNSLETIERLAFYGNLELKELILPDN
VKNFGKHVMNGLPKLKSLTIGNNINSLPSFFLSGVLDSLKEIHIKNKSTEFSVKKDTFAIPETVKFYVTS
EHIKDVLKSNLSTSNDIIVEKVDNIKQETDVAKPKKNSNQGVVGWVKDKGLWYYLNESGSMATGWVKDKG
LWYYLNESGSMATGWVKDKGLWYYLNESGSMATGWVKDKGLWYYLNESGSMATGWVKDKGLWYYLNESGS
MATGWFKDKGLWYYLNESGSMATGWFTVSGKWYYTYNSGDLLVNTTTPDGYRVNANGEWVG

Epitope Information

IEDB Linear Epitope