VIOLIN: Vaccine Investigation and Online Information Network

endopeptidase O(PepO)

General Information

Protegen ID

4157

Sequence Strain (Species/Organism)

Streptococcus pneumoniae

Taxonomy ID

914147

Molecule Role

Protective antigen

Molecule Role Annotation

The results of colonization experiment showed that compared with the control group, the PepO, PsaA, and combined immunization groups showed a significant reduction in the colonization of Streptococcus pneumoniae (CMCC31693 and CMCC31207) in the nasopharynx and lung (P<0.05).(Zhang et al., 2017)

References

Zhang et al., 2017: Zhang J, Cui YL, Jiang YM. [Immunoprotective effect of combined pneumococcal endopeptidase O and pneumococcal surface adhesin A vaccines against Streptococcus pneumoniae infection]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics. 2017; 19(5); 583-589. [PubMed: 28506354].

Gene Information

Gene Name

endopeptidase O(PepO)

Protein Information

Protein Name

endopeptidase O

NCBI Protein GI

EJG73599

Protein pI

4.43

Protein Weight

68202.47

Protein Length

703

Protein Sequence

>EJG73599.1 endopeptidase O [Streptococcus pneumoniae 2082239]
MTRYQDDFYDAINGEWQQTAEIPADKSQTGGFVDLDQEIEDLMLATTDKWLAGEEVPEDAILENFVKYHR
LVRDFDKREADGITPVLPLLKEFQELETFADFTAKLAEFELAGKPNFLPFGVSPDFMDARINVLWASAPS
TILPDTTYYAEEHPQREELLTLWKESSANLLKAYDFSDEEIEDLLEKRLELDRRVAAVVLSNEESSEYAK
LYHPYSYEDFKKFAPALPLDDFFKAVIGQLPDKVIVDEERFWQAAEQFYSEEAWSLLKATLILSVVNLST
SYLTEDIRVLSGAYSRALSGVPEAKDKVKAAYHLAQEPFKQALGLWYAREKFSPEAKADVEKKVATMIDV
YKERLLKNDWLTPETCKQAIVKLNVIKPYIGYPEELPARYKDKVVNETASLFENALAFARVEIKHSWSKW
NQPVDYKEWGMPAHMVNAYYNPQKNLIVFPAAILQAPFYDLHQSSSANYGGIGAVIAHEISHAFDTNGAS
FDENGSLKDWWTESDYAAFKEKTQKVIDQFDGQDSYGATINGKLTVSENVADLGGIAAALEAAKREADFS
AEEFFYNFGRIWRMKGRPEFMKLLASVDVHAPAKLRVNVQVPNFDDFFTTYDVKEGDGMWRSPEERVIIW

Epitope Information

IEDB Linear Epitope