VIOLIN: Vaccine Investigation and Online Information Network

phtB

General Information

Protegen ID

4159

Sequence Strain (Species/Organism)

Streptococcus pneumoniae

Taxonomy ID

257758

Other Database IDs

CDD:273578; CDD:282170; CDD:293251; CDD:114603

Molecule Role

Protective antigen

Molecule Role Annotation

Seven proteins induced protective responses, in terms of reduced lung burdens of the serotype 3 pneumococci. Three of the protective proteins were histidine triad protein family members.(Anderson et al., 2016)

References

Anderson et al., 2016: Anderson RJ, Guru S, Weeratna R, Makinen S, Falconer DJ, Sheppard NC, Lang S, Chang B, Goenaga AL, Green BA, Merson JR, Gracheck SJ, Eyles JE. In vivo screen of genetically conserved Streptococcus pneumoniae proteins for protective immunogenicity. Vaccine. 2016; 34(50); 6292-6300. [PubMed: 27816374].

Gene Information

Gene Name

phtB

Protein Information

Protein Name

pneumococcal histidine triad protein B

NCBI Protein GI

KPL42694

Protein pI

5.5

Protein Weight

108278.97

Protein Length

1129

Protein Note

Derived by automated computational analysis using gene prediction method: Protein Homology.

Protein Sequence

>KPL42694.1 pneumococcal histidine triad protein B [Streptococcus pseudopneumoniae]
MKINKKYLAGSVAVLALSVCSYELGRYQAGQAKKESNRVAYIDGNQAGQKAENLTPDEVSKREGINAEQI
VIKITDQGYVTSHGDHYHYYNGKVPYDAIISEELLMKDSNYQLKDSDIVNEIKGGYVIKVNGKYYVYLKD
AAHADNIRTKEEIKRQKQEHSSNHGGGSNNQAVVAARAQGRYTTDDGYIFNASDIIEDTGDAYIVPHGNH
FHYIPKSDLSASELAAAQAFLSGKGGQLSTVEYRSSRGETRSSVRTSPSETPQNLTTTPESQNENLASLL
QELYALALSQRHVESDGLVFDPAQITKRTANGVAVPHGDHFHFIPYSQMSALEEKLARNLPIGGQPVQKH
SDNTKPSSPAKPSSAIKANFNLNTQAPNRATGGAYTTDDGYVFSPTDVIEDTGDAFVVPHGNHFHYIPKS
DLSAGELAAAQAYWNGKQGSRPSSSSSHNANPAQPSLSENHNLTVTPTYHQNQGEDIPSLLRELYAKPLS
ERHVESDGLVFDPAQITNRTANGVAVPHGDHYHFIPYSQMSPLEEKLARMIAIKGQNGAVLPGMNYLKPA
PKPQAQPSTEKKQTDFTVEQVVRKVGEGYVVEIAGVSHYVFAKDLAKDKIDAIENLLSKKTQETHALVAK
KENVASRDQEFYDKAYNLLTQAHKALSENKGRVSDFQTLDKLAERLNDESSNKVKLVDDLLAFLAPITHP
ERLGKPNAQIAYTDDEIKLAKLAGKYTTEDGYIFDEHDIESDEGNAYVTPHLNHSHWIKKDSLSEAERAA
AQAYAKEKGLQAPNSTEATEAKPEATGTEAIYNRVKAEKKVPLEKIPNHLQYTVAVQNGHFIIPHFDHYH
NLKFAWFDEGLYSAPEGYTLEDLFATVKYYVEHPDQRPHSDNGWGNASDHVRKNKADQNGKPDEDKEHDE
VSEPTHSESDEKENHAGLNPSADNLYRPSTDAEETEEEAEDTTDEDEVPQVERSVIDVKIAEAETLLEKV
TDSRTRQNAMETLSGLNSSLLFGTKDSNTISAELDRLLALLKESQPTPI

Epitope Information

IEDB Linear Epitope