VIOLIN: Vaccine Investigation and Online Information Network

dnaX

General Information

Protegen ID

416

Sequence Strain (Species/Organism)

Chlamydophila abortus

VO ID

VO_0011056

Taxonomy ID

218497

Other Database IDs

CDD:180523
EnsemblGenomes-Gn:CAB327
EnsemblGenomes-Tr:CAH63776
GOA:Q5L6F0
InterPro: IPR003593
InterPro: IPR008921
InterPro: IPR012763
InterPro: IPR027417
UniProtKB/TrEMBL: Q5L6F0

Molecule Role

Protective antigen

Molecule Role Annotation

Genetic immunization was used to functionally test the genes of C. abortus as vaccines in a mouse challenge system. DNA pol III Gamma and Tau (CP #1, dnaX) was found to be protective. CP #1 (dnaX) was more protective than the live-vaccine, positive control. (Stemke-Hale et al., 2005).

Related Vaccines(s)

C. abortus DNA vaccine encoding DnaX

References

Stemke-Hale et al., 2005: Stemke-Hale K, Kaltenboeck B, DeGraves FJ, Sykes KF, Huang J, Bu CH, Johnston SA. Screening the whole genome of a pathogen in vivo for individual protective antigens. Vaccine. 2005; 23(23); 3016-3025. [PubMed: 15811648].

Gene Information

Gene Name

dnaX

Protein Information

Protein Name

DNA polymerase III subunit gamma/tau

NCBI Protein GI

62148024

Protein pI

6.44

Protein Weight

47941.3

Protein Length

526

Protein Note

DNA polymerase III subunits gamma and tau; Validated

Protein Sequence

>CAH63776.1 DNA polymerase III subunit gamma/tau [Chlamydia abortus S26/3]
MTSATYQVSSRKYRPQTFAEMLGQDAVVTVLKNALQFQRVAHAYLFSGIRGTGKTTLARIFAKALNCKEL
TPEHEPCNQCCVCKEISSGTSLDVIEIDGASHRGIEDIRQINETVLFTPAKSQYKIYIIDEVHMLTKEAF
NSLLKTLEEPPSHVKFFLATTENYKIPSTILSRCQKMHLKRIPETMIVDKLASISQAGGIETSREALLPI
ARAAQGSLRDAESLYDYVIGLFPTSLSPELVADALGLLSQDTLATLSECIRTQKYAEALLPVTTAINSGV
APITFLHDLTVFYRDVLLNKDQGNSPLSAIAMHYSSECLLEIIDFLGEAAKHLQQTIFEKTFLETVIIHL
IRICQRPSLETLFSQLKTSTFDTVRNVPQQQEPSKPSIQPEKHYQDQSFLTSPSPTPKVQHQKEASPSLV
GSATIDTLLQFAVVEFSGILTKE

Epitope Information

IEDB Linear Epitope